Advanced imaging and AI for detecting and staging osteoporosis and osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project develops and validates a multimodal AI platform that combines X‑ray, CT, MRI, clinical laboratory markers, and patient history to detect and stage osteoporosis and osteoarthritis. A retrospective cohort of about 1,500 patients from Peking University People's Hospital (2005–2025) will be used for model development, and at least 500 prospectively recruited adults will provide external validation beginning December 2025. The AI will quantify bone mineral density and microarchitecture for osteoporosis and identify radiographic markers such as joint space narrowing and osteophytes for osteoarthritis to produce standardized staging. The work is non‑interventional and aims to reduce inter‑observer variability and improve objectivity in imaging-based musculoskeletal assessment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: Adults aged at least 18 years.
* Gender: No gender restrictions; both male and female participants are eligible.
* Imaging Data: Participants must have completed relevant clinical imaging scans of skeletal sites, including but not limited to X-ray, CT (plain scan), or MRI (plain scan).
* Anatomical Integrity: The skeletal structure of the target area must be free from congenital or acquired deformities.
* Absence of Implants: No internal fixation materials or orthopedic implants in the skeletal areas being assessed.

Exclusion Criteria:

* Pathological History: Patients with a history of prior pathological fractures.
* Malignancy: Patients seeking treatment or diagnosed with bone tumors or other systemic malignancies.
* Medication History: Patients with a history of long-term steroid use, which may significantly affect bone density and joint structure.
* Recent Treatment: Patients who have undergone radiotherapy or chemotherapy within the past six months.
* Data Quality: Patients whose imaging data is of insufficient quality for AI analysis or lacks clear clinical diagnostic "gold standard" references (e.g., missing DXA results for osteoporosis staging).

Where it's running

• Beijing, China Recruiting

Study contacts

• Study coordinator: Yuhui Kou, M.D
• Email: yuhuikou@bjmu.edu.cn
• Phone: 13146213332

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.