Condition

Obsessive-Compulsive Disorder clinical trials and research

• 79Clinical trials
• 29NIH research projects
• 1New in 30 days
• 20Countries

Newest Obsessive-Compulsive Disorder clinical trials

All recruiting trials (79)

• Low-intensity focused ultrasound targeting the subthalamic nucleus for OCD

  A short test is being done to see if a wearable, non-invasive ultrasound device can safely and tolerably help adults with OCD by targeting a brain region called the subthalamic nucleus.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT07887633

• Mindfulness-Based Cognitive Therapy for OCD Delivered Online

  This study tests a synchronous online MBCT program for adults with OCD to see if it is acceptable and feasible and to explore links between biological markers, OCD severity, and treatment response.

  Recruiting IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia · NCT07834567

• Targeted brain stimulation for OCD: test of tTIS on nucleus accumbens

  This study tests whether targeted temporal interference stimulation of the nucleus accumbens can help reduce obsessive-compulsive symptoms in adults with OCD, compared with sham stimulation.

  Recruiting Beijing HuiLongGuan Hospital · Hefei, Anhui · NCT07805200

• Anxiety Skills Study: See if video skill training plus therapy helps people with anxiety

  This study tests whether a brief video-based skill training can help people with anxiety as well as four therapy sessions, and how durable the effects are over a year.

  Recruiting Ohio State University · Columbus, Ohio · NCT07774481

• AttunE LIFU for OCD: a non-invasive brain stimulation study

  This trial tests ATTN201, a wearable ultrasound headband, to see if it helps adults with OCD compared to a sham treatment.

  Recruiting Phase 2 University of Pennsylvania · San Francisco, California · NCT07728994

• Combined ERP and Habit Reversal Therapy for Tourettic OCD

  This study tests whether a merged Exposure and Response Prevention and Habit Reversal Therapy helps adults with Tourettic OCD more than either therapy alone or basic psychoeducation.

  Recruiting at 2 sites University College London Hospitals · London, London and 1 other locations · NCT07725926

• Safety and feasibility of a next-generation dome helmet for neuromodulation in OCD

  This study tests whether a new focused ultrasound helmet can safely help people with treatment-refractory OCD see if their symptoms improve.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07704632

• Digital Mindfulness Therapy for Obsessive-Compulsive Disorder

  A 6-week digital mindfulness program is being tested to see if it helps people with OCD, either alone or with standard OCD medication, compared with medication alone.

  Recruiting at 2 sites Central South University · Changsha, Hunan and 1 other locations · NCT07701616

• Emotion-Focused ACT for OCD in Group Therapy

  In adults with OCD, researchers will test whether Emotion-Focused Acceptance and Commitment Therapy (ACT) delivered in a group setting helps reduce OCD symptoms compared with a supportive group.

  Recruiting Goztepe Prof Dr Suleyman Yalcın City Hospital · Istanbul, Istanbul · NCT07622654

• Using brain activity markers to predict response to accelerated iTBS for OCD

  This will try accelerated intermittent Theta Burst Stimulation (iTBS) targeting the dmPFC and ACC to reduce symptoms in adults (18–65) with treatment‑resistant OCD and to find brain activity markers that predict who benefits.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Bakirkoy · NCT07561528

• Digital stepped-care mindfulness program for emotional disorders

  This project tests whether adding an online mindfulness program to usual care helps adults (18–65) with depression, anxiety, OCD, or PTSD recover faster and stay well longer.

  Recruiting Peking University · Beijing · NCT07458100

• Whole-mushroom psilocybin for obsessive-compulsive disorder.

  This trial tests whether different doses of whole psilocybin mushroom in chocolate can help adults with moderate-to-severe OCD who are not taking other psychoactive medications or street drugs.

  Recruiting Phase 1 University of Arizona · Tucson, Arizona · NCT07347405

• Virtual reality exposure therapy for obsessive-compulsive disorder in hospitalized patients

  This trial tests whether adding immersive virtual-reality exposure to standard CBT helps hospitalized people with OCD reduce symptoms more than CBT alone or CBT with VR cognitive training.

  Recruiting National Institute of Mental Health, Czech Republic · Klecany · NCT07245134

• Brief culturally adapted cognitive behavioral therapy for OCD

  This program will try a short, culturally adapted form of cognitive behavioral therapy to help adults with obsessive-compulsive disorder.

  Recruiting Pakistan Association of Cognitive Therapists · Lahore, Punjab Province · NCT07232823

• Virtual reality exposure therapy for outpatients with OCD

  This study will test whether virtual reality exposure therapy can reduce OCD symptoms in adults receiving outpatient psychiatric or psychological care.

  Recruiting National Institute of Mental Health, Czech Republic · Klecany, Česká Republika · NCT07206199

• Accelerated personalized rTMS for treatment‑resistant obsessive‑compulsive disorder

  This study will try a fast, personalized course of repetitive transcranial magnetic stimulation (rTMS) targeting the right inferior frontal cortex to see if it reduces symptoms in adults with treatment‑resistant OCD.

  Recruiting Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University · Shanghai, Shanghai Municipality · NCT07198594

• Project EMPOWER-OCD: a one-time online program for OCD caregiver families

  We’re testing a single, self-guided online session to help caregivers reduce accommodating behaviors for a child with OCD.

  Recruiting Boston University Charles River Campus · Boston, Massachusetts · NCT07158801

• Transcranial magnetic stimulation combined with therapy for OCD

  This trial will test whether combining repetitive transcranial magnetic stimulation (rTMS) with either Exposure and Response Prevention (ERP) or supportive therapy helps adults with OCD.

  Recruiting University of Southern California · Los Angeles, California · NCT07146438

• Accelerated rTMS for hospitalized patients with OCD

  We will test whether adding accelerated rTMS (dTMS or iTBS) to inpatient ERP helps adults hospitalized with moderate-to-severe OCD.

  Recruiting University Hospital, Ghent · Ghent, Oost-Vlaanderen · NCT07135414

• Accelerated rotational-field deep TMS for obsessive-compulsive disorder

  This will try a short, accelerated course of BrainsWay rotational-field Deep TMS to reduce symptoms in adults with moderate-to-severe OCD.

  Recruiting Ben-Gurion University of the Negev · Beersheba · NCT07116785

• Transcranial magnetic stimulation for teens with OCD

  This project will test two types of transcranial magnetic stimulation to see if they are safe, tolerable, and show early benefit for teenagers (13–17) with moderate-to-severe OCD who have not improved enough with usual treatments.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07065669

• Deep brain stimulation of the anterior limb of the internal capsule and nucleus accumbens for treatment‑resistant OCD

  This trial will test whether turning on deep brain stimulation at 1, 2, or 3 months after surgery changes symptom improvement in adults with treatment‑resistant OCD.

  Recruiting at 10 sites Shanghai Mental Health Center · Guangzhou, Guangdong and 9 other locations · NCT07031544

• Using EEG and computational models to better understand compulsivity in OCD

  This project will test whether combining EEG recordings with computational cognitive models can reveal distinct brain and behavior patterns in adults with OCD compared to adults without OCD.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07011901

• Family-based CBT self-help program for adolescents with OCD

  This trial will test whether a family-based CBT self-help book plus stable medication helps adolescents aged 10 to 17 reduce OCD symptoms more than medication alone.

  Recruiting Shanghai Mental Health Center · Xuhui, Shanghai Municipality · NCT06942494

• Analyzing patient data to understand TMS effects on depression and anxiety

  This study looks at real patient data to see how different factors affect the success of TMS therapy for people dealing with depression and anxiety.

  Recruiting Neuronetics · Malvern, Pennsylvania · NCT06917339

• Pediatric OCD and gut-brain microbiome links in kids on SSRIs

  This study tests whether the gut microbiome and related markers change in children and teens with OCD when treated with SSRIs, and compares those results with kids who have OCD with tic disorders and healthy peers.

  Recruiting Shanghai Mental Health Center · Shanghai, Shanghai Municipality · NCT06754319

• Evaluating outcomes in neurosurgery using standardized measures

  This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.

  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• Using deep transcranial magnetic stimulation to treat obsessive-compulsive disorder

  This study is testing whether a new type of brain stimulation can help people with obsessive-compulsive disorder feel better.

  Recruiting Shanghai Mental Health Center · Shanghai, Shanghai Municipality · NCT06692114

• Deep brain stimulation for severe, treatment-resistant OCD

  This trial will try deep brain stimulation of the anteromedial subthalamic nucleus to see if it reduces symptoms in adults with severe, treatment-resistant OCD.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06660225

• Deep brain stimulation for severe obsessive-compulsive disorder

  This study is testing if deep brain stimulation can help people with severe obsessive-compulsive disorder who haven't found relief with other treatments.

  Recruiting Umeå University · Umeå, Västerbotten County · NCT06628752

• Concentrated exposure and response prevention for children with OCD

  This study is testing a new week-long treatment for children aged 6-12 with OCD to see if it helps reduce their symptoms and improve their daily lives.

  Recruiting Uppsala University Hospital · Uppsala, Region Uppsala · NCT06621381

• Using Pramipexole to Treat Resistant Obsessive-Compulsive Disorder

  This study is testing if the medication pramipexole can help people with obsessive-compulsive disorder who haven't found relief from other treatments.

  Recruiting Phase 2 Clinical Academic Center (2CA-Braga) · Braga · NCT06611592

• Registry for pediatric deep brain stimulation outcomes

  This study is creating a database to collect information on how deep brain stimulation helps children with movement disorders like dystonia and Tourette syndrome, to see how safe and effective the treatment is.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06585618

• Internet therapy for OCD in children with autism

  This study is testing an online therapy program to see if it can help children with autism and OCD feel better by reducing their symptoms.

  Recruiting at 3 sites Karolinska Institutet · Lund, Skåne County and 2 other locations · NCT06582225

• RR-HNK treatment for obsessive-compulsive disorder.

  This pilot will test whether two intravenous doses of RR-HNK can reduce symptoms in adults with obsessive-compulsive disorder who have not fully responded to standard treatments.

  Recruiting Phase 1/2 Stanford University · Palo Alto, California · NCT06575075

• Exploring the role of the orbitofrontal cortex in obsessive-compulsive disorder

  This study looks at how a specific part of the brain might be linked to symptoms of obsessive-compulsive disorder in people with OCD and compares them to healthy individuals to better understand the condition.

  Recruiting Fundacao Champalimaud · Lisbon · NCT06566781

• Identifying brain biomarkers for treating obsessive-compulsive disorder with deep brain stimulation

  This study is testing if deep brain stimulation can help people with obsessive-compulsive disorder who haven't found relief from regular treatments by looking for brain signals that might predict their symptoms.

  Recruiting at 2 sites West China Hospital · Chengdu, Sichuan and 3 other locations · NCT06542224

• French bibliotherapy program for obsessive-compulsive symptoms

  This study is testing a French self-help reading program to see if it can help people with obsessive-compulsive disorder feel better without changing their medication.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice · NCT06494735

• Natural psychotherapy for treating obsessive-compulsive disorder

  This study is testing if natural psychotherapy can help people with obsessive-compulsive disorder improve their thinking, mood, and sleep.

  Recruiting at 2 sites Beijing HuiLongGuan Hospital · Hefei, Anhui and 1 other locations · NCT06443125

• Exploring new brain stimulation targets for mental health conditions

  This study is testing how a brain stimulation treatment can help people with depression, anxiety, OCD, and schizophrenia by looking at changes in their brain and behavior.

  Recruiting Phase 2 Brigham and Women's Hospital · Sunnyvale, California and 1 other locations · NCT06376734

• Imagery rescripting treatment for OCD and BDD

  This study is testing a new therapy called imagery rescripting to see if it can help people with Obsessive Compulsive Disorder and Body Dysmorphic Disorder feel better and change their negative thoughts.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam-Zuidoost, North Holland · NCT06346301

• New treatment approach for obsessive-compulsive disorder

  This study is testing whether a new therapy called Inference-based Cognitive Behavioral Therapy can help people with obsessive-compulsive disorder feel better compared to the usual treatment they’ve already tried.

  Recruiting Ciusss de L'Est de l'Île de Montréal · Montreal, Quebec · NCT06318806

• Prevention program for adults at risk of OCD

  This study is testing a two-week program to see if it can help adults at risk of developing OCD feel better compared to those who just get regular treatment.

  Recruiting Babes-Bolyai University · Cluj-Napoca, Romania · NCT06262464

• Understanding how exposure therapy works for OCD

  This study is trying to understand how exposure therapy helps people with obsessive-compulsive disorder (OCD) by looking at different factors that affect how well the treatment works.

  Recruiting at 2 sites Mclean Hospital · San Diego, California and 1 other locations · NCT06173752

• Using tDCS with symptom provocation to treat resistant OCD

  This study is testing if a new treatment using brain stimulation along with triggering OCD symptoms can help people with severe OCD who haven't found relief from other treatments.

  Recruiting Centre Hospitalier Henri Laborit · Poitiers · NCT06017713

• Deep Brain Stimulation for treating severe Obsessive-Compulsive Disorder

  This study is testing if Deep Brain Stimulation surgery can help people with severe Obsessive-Compulsive Disorder who haven't found relief from other treatments.

  Recruiting Rabin Medical Center · Petah Tikva · NCT05995951

• Understanding how ketamine affects OCD symptoms

  This study is testing whether ketamine can help people with OCD who haven't found relief from other treatments by looking at how it affects their brain activity.

  Recruiting Phase 2 Stanford University · Stanford, California · NCT05940324

• Predicting the effectiveness of online therapy for obsessive-compulsive disorder

  This study is testing if online therapy can help people with obsessive-compulsive disorder feel better by comparing their progress to those who are not receiving the treatment.

  Recruiting University of Minho · Braga, Gualtar · NCT05906069

• MDMA-assisted cognitive behavioral therapy for obsessive-compulsive disorder

  This trial will test whether MDMA combined with cognitive behavioral therapy can help adults with OCD have fewer symptoms.

  Recruiting Phase 2 Stanford University · Palo Alto, California · NCT05783817

• Combining neurostimulation with emotion regulation training for emotional issues

  This study is testing if combining brain stimulation with training on how to manage emotions can help people with emotional issues feel better.

  Recruiting Duke University · Durham, North Carolina · NCT05712057

• Investigating brain and genetic changes in anxiety and OCD treatment

  This study is testing how a special 4-day therapy for OCD and other anxiety disorders affects both mental health and brain changes in patients, while also looking at their DNA.

  Recruiting Haukeland University Hospital · Bergen, Vestland · NCT05663489

• Personalized emotion regulation skills training

  This study is testing if teaching people personalized ways to manage their emotions can help them feel less negative every day compared to using standard methods.

  Recruiting Ohio State University · Columbus, Ohio · NCT05651295

• Deep brain stimulation for severe obsessive-compulsive disorder

  This study is testing if deep brain stimulation can help people with severe obsessive-compulsive disorder who haven't found relief from other treatments.

  Recruiting University of Pennsylvania · Stanford, California and 1 other locations · NCT05623306

• Using CBT to help kids with OCD stop medication safely

  This study is testing if kids and teens with OCD can safely stop their medication after getting extra help from online therapy.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05609916

• Glucose Consumption During Deep Brain Stimulation With Functional [18F]FDG-Brain-PET in Obsessive-Compulsive Disorder

  This study is testing how the brain uses sugar during deep brain stimulation to see if it helps people with obsessive-compulsive disorder.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT05577598

• Using ketamine to treat obsessive-compulsive disorder

  This study is testing if low-dose ketamine can help people with obsessive-compulsive disorder feel better by comparing it to another treatment.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT05577585

• Understanding why OCD therapy fails

  This study is trying to understand why therapy sometimes doesn't work for people with OCD by looking at their brain activity and behavior before and after treatment.

  Recruiting University College, London · London · NCT05520398

• Evaluating CO2 Reactivity to Predict Response to Exposure Therapy for Anxiety Disorders

  This study is testing whether measuring how people react to CO2 can help predict if adults with anxiety disorders will benefit from exposure therapy.

  Recruiting at 2 sites University of Texas at Austin · Boston, Massachusetts and 1 other locations · NCT05467683

• Training to improve response inhibition in obsessive-compulsive disorders

  This study is testing a new computer training program to see if it can help people with obsessive-compulsive disorders, like OCD and skin picking, improve their ability to control their urges.

  Recruiting University of Wisconsin, Milwaukee · Milwaukee, Wisconsin · NCT05377125

• Using cognitive bias modification to improve treatment for OCD

  This study is testing if a new digital program that helps change how people think can improve treatment for adults with obsessive-compulsive disorder (OCD).

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT05224414

• Targeted brain stimulation for contamination-based OCD

  This study is testing a new brain stimulation treatment to see if it can help people with OCD who struggle with contamination and washing symptoms feel better.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT05048251

• Using rTMS on the Orbito Frontal Cortex for Obsessive-Compulsive Disorder

  This study is testing whether a new brain stimulation treatment can help adults with obsessive-compulsive disorder who haven't found relief from other medications.

  Recruiting at 2 sites Centre Hospitalier Henri Laborit · Paris and 1 other locations · NCT04934007

• Evaluating the impact of self-help CBT in primary care behavioral health

  This study is testing if adding guided self-help therapy to regular mental health care can help patients feel better and improve their daily lives.

  Recruiting at 2 sites Linnaeus University · Varberg, Halland County and 3 other locations · NCT04900064

• Testing dextromethorphan for treating OCD and related disorders

  This study is testing if adding a common cough medicine called dextromethorphan to the usual OCD treatment can help people with OCD and similar disorders feel better.

  Recruiting Phase 2 Stanford University · Stanford, California · NCT04899687

• Psilocybin-assisted psychotherapy for severe OCD

  This study is testing whether combining therapy with psilocybin can help people with severe OCD who haven't found relief from regular treatments.

  Recruiting Phase 2 Beersheva Mental Health Center · Beersheba · NCT04882839

• Intensive treatment for children and adolescents with obsessive-compulsive disorder

  This study tests a short and intensive treatment program for children and teens with obsessive-compulsive disorder to see if it helps them feel better and function well in their daily lives.

  Recruiting Psychiatric University Hospital, Zurich · Zurich, Canton of Zurich · NCT04730011

• Evaluation of obsessive-compulsive disorders in children and young adults

  This study is looking to understand obsessive-compulsive disorders in kids and teens aged 8 to 18 to find ways to make their treatment better and faster.

  Recruiting Psychiatric University Hospital, Zurich · Zurich, Canton of Zurich · NCT04723485

• Understanding brain development and behaviors like impulsivity and compulsivity

  This study looks at how brain development affects impulsive and compulsive behaviors in people aged 6 to 80 to see if there are links between genetics and brain features.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04631042

• Evaluating treatment options for Obsessive-Compulsive Disorder

  This study is testing different treatment options for people with Obsessive-Compulsive Disorder who didn't get better with the medication sertraline to see what works best for them.

  Recruiting Phase 2 Shanghai Mental Health Center · Shanghai, Shanghai Municipality · NCT04539951

• Registry for patients with treatment-resistant depression and OCD receiving interventional therapies

  This study is testing different treatments like ECT, TMS, and ketamine to see how they help people with treatment-resistant depression and OCD feel better.

  Recruiting University of Iowa · Iowa City, Iowa · NCT04480918

• Using brain imaging to predict response to TMS in OCD treatment

  This study is testing if brain scans can help predict how well a new type of brain stimulation treatment will work for people with OCD who haven't found relief from other treatments.

  Recruiting Stanford University · Stanford, California · NCT04286126

• Brain changes linked to treatment responses in OCD

  This study is testing how treatment with fluoxetine affects brain activity in people with obsessive-compulsive disorder (OCD) to see if it helps improve their symptoms.

  Recruiting Phase 1/2 Yale University · New Haven, Connecticut · NCT04131829

• Identifying genetic factors in children affected by antidepressant side effects

  This study is trying to find out if certain genes can help predict which children might have negative side effects from antidepressants, so doctors can better manage their treatment.

  Recruiting University of Calgary · Calgary, Alberta · NCT03953014

• Using caloric vestibular stimulation to improve insight in obsessive-compulsive disorders

  This study is testing whether a special type of brain stimulation can help people with obsessive-compulsive disorders better understand their thoughts and behaviors to improve their treatment outcomes.

  Recruiting Stanford University · Stanford, California · NCT03918577

• Using nitrous oxide to treat obsessive-compulsive disorder

  This study is testing if breathing in nitrous oxide can quickly help adults with obsessive-compulsive disorder feel better.

  Recruiting Phase 2 Stanford University · Stanford, California · NCT03826693

• Quality of Life Improvement for Patients with Resistant OCD Using Deep Brain Stimulation

  This study is testing if Deep Brain Stimulation can help people with severe OCD who haven't found relief from other treatments feel better and improve their quality of life.

  Recruiting at 7 sites University Hospital, Grenoble · Créteil and 7 other locations · NCT02844049

• Study on how genetics and microbiome affect OCD treatment with SSRIs

  This study is testing how genetics and gut bacteria might influence how well people with obsessive-compulsive disorder respond to a common medication called SSRIs.

  Recruiting Severance Hospital · Seoul · NCT02431845

• Group-based Family Cognitive-Behavioural Therapy for Pediatric OCD

  This study tests whether a new group therapy that includes families can help children and teens with Obsessive-Compulsive Disorder feel better and improve their family life.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT01635569

• Development of a brain atlas for improved treatment of neurological conditions

  This study is trying to create a detailed brain map to help doctors find the best treatment spots for patients with conditions like Parkinson's, OCD, and epilepsy.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT00575081

NIH-funded research (29)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Exposure and Response Prevention for Veterans with OCD (via video), to help daily functioning

  A Veterans-focused program tests video-delivered ERP therapy to help people with OCD and sometimes PTSD feel more able to work and enjoy daily life.

  NIH research Michael E Debakey VA Medical Center · Houston, United States · NIH-11534223

• Understanding and improving fear and safety learning in OCD

  A study at Yale will test brain-based methods to help adults with OCD improve safety learning and fear extinction during therapy.

  NIH research Yale University · New Haven, United States · NIH-11415686

• Understanding OCD: how people control distressing thoughts and urges

  A research team is exploring how the brain and behavior work together in OCD to reduce distress and urge-driven actions.

  NIH research Laureate Institute for Brain Research · Tulsa, United States · NIH-11413540

• Neural training to improve stopping impulses in OCD and related conditions

  A new computer-based training helps people with OCD, trichotillomania, or skin picking disorders improve their ability to stop automatic urges.

  NIH research University of Wisconsin Milwaukee · Milwaukee, United States · NIH-11397434

• How genes affect obsessive-compulsive disorder in people of Latin American ancestry

  This project looks at how genetic differences influence OCD risk in people with Latin American ancestry.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11381494

• Pinpointing brain areas and cell types linked to OCD, Tourette, and anorexia with genetics

  A short, patient-friendly project that looks at how genes are connected to OCD, Tourette syndrome, and anorexia nervosa to understand which brain regions and cells are involved.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11356863

• Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder

  This project studies how targeting brain networks with DBS could improve symptoms for people with OCD who don’t respond to standard treatments.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11323974

• Brain circuits and decision-making in obsessive-compulsive disorder

  Researchers will use brain scans and decision-making tasks to understand why people with obsessive-compulsive disorder have rigid thoughts and behaviors.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11266202

• Improving safety learning and brain connectivity in adults with OCD

  This project sees if gentle brain stimulation plus exposure therapy helps adults with OCD learn safety faster and reduce fear-driven symptoms.

  NIH research Yale University · New Haven, United States · NIH-11253546

• Capacity-building to bring OCD therapy to community clinics

  A plan to teach community clinicians how to deliver effective exposure and response prevention therapy for OCD using a fully remote learning program.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11215697

• Cognitive control targets to help kids with OCD

  A new at-home computer training program for children with OCD aims to strengthen thinking skills to reduce symptoms and improve response to therapy.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11195184

• Improving functioning in veterans with obsessive-compulsive disorder through therapy

  This study is looking at how well a therapy called Exposure and Response Prevention (ERP) works for veterans with obsessive-compulsive disorder (OCD), especially since many also deal with PTSD and have trouble getting to therapy; by using video calls for therapy, the researchers want to see if this helps veterans manag

  NIH research Michael E Debakey VA Medical Center · Houston, United States · NIH-11191410

• Brain training to help stop compulsive behaviors

  This project tests a computerized brain-training program for adults with OCD, hair-pulling, or skin-picking to help them better stop unwanted urges.

  NIH research University of Wisconsin Milwaukee · Milwaukee, United States · NIH-11178431

• Using deep brain stimulation to treat severe obsessive-compulsive disorder

  This study is looking at how deep brain stimulation can help people with severe obsessive-compulsive disorder by targeting specific areas in the brain, and it’s for individuals who are struggling with OCD and want to explore new treatment options.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11175481

• How the brain handles efforts to neutralize perceived threats in OCD

  This project looks at how people with OCD's brains act when they try to neutralize or avoid perceived threats that trigger compulsions.

  NIH research Laureate Institute for Brain Research · Tulsa, United States · NIH-11145210

• Genetic roots of OCD in Latin American people

  This project collects DNA and health information from Latin American people with OCD to find genes that may raise the chance of having OCD.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11115651

• Genetics of OCD in Latin American and diverse populations

  Researchers are finding how genes influence the risk of obsessive-compulsive disorder in people from Latin America and other ancestries by collecting DNA and clinical information.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11113931

• Understanding the brain mechanisms behind obsessive-compulsive disorder

  This study is looking at how the brain works in people with obsessive-compulsive disorder (OCD) to better understand their symptoms and improve treatment options, using advanced brain scans and computer models to see how different parts of the brain are connected and make decisions.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11111451

• Investigating the cholinergic system's role in Obsessive Compulsive Disorder

  This study is looking at how a part of the brain that uses a chemical called acetylcholine might be linked to obsessive-compulsive disorder (OCD) by using mice that show similar behaviors, with the hope of finding new ways to help people with OCD feel better.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11109641

• Improving Deep Brain Stimulation for Obsessive Compulsive Disorder

  This study is looking for better ways to use Deep Brain Stimulation to help people with Obsessive Compulsive Disorder who haven't found relief with regular treatments, by focusing on the connections in the brain to find the best spots to stimulate, and patients may get a chance to join trials that could lead to more ta

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11094839

• Investigating rare genetic variations linked to obsessive-compulsive disorder

  This study is looking at how certain rare genetic changes might affect the chances of developing obsessive-compulsive disorder (OCD), and it's for people with OCD and their families to help improve understanding and treatment options.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10976441

• Investigating how rare genetic variations affect the risk of obsessive-compulsive disorder.

  This study is looking at how rare genetic changes might affect the chances of developing obsessive-compulsive disorder (OCD) by comparing the genes of over 5,100 people with OCD to those of 3,000 people without it, hoping to find clues that could help us better understand and treat the condition.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10974472

• Training the brain to improve response control in people with obsessive-compulsive disorder

  This study is looking at whether a new computer training program can help people with obsessive-compulsive disorder (OCD) and similar issues better control their impulses, and it involves comparing those who use the training with those who don’t to see how it affects their brain activity and symptoms.

  NIH research University of Wisconsin Milwaukee · Milwaukee, United States · NIH-10950397

• Using light therapy to help treat obsessive-compulsive disorder

  This study is looking at whether light therapy can help people with obsessive-compulsive disorder (OCD) by possibly resetting their body clocks, and it involves two groups—one getting real light therapy and the other getting a fake treatment—to see if it can reduce OCD symptoms.

  NIH research Washington University · Saint Louis, United States · NIH-10949780

• Understanding and improving fear responses in people with obsessive-compulsive disorder

  This study is looking at how people with obsessive-compulsive disorder (OCD) can learn to feel safer and how their brains might work differently, using a special technique to boost brain activity during therapy, all to find better ways to help those with OCD feel better.

  NIH research University of Kentucky · Lexington, United States · NIH-10944269

• Improving cognitive control to help treat obsessive-compulsive disorder in young children

  This study is looking to help kids aged 8 to 12 with obsessive-compulsive disorder (OCD) by using a fun computer program they can do at home to boost their ability to manage their thoughts and actions, making traditional therapy even more effective.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10927361

• Understanding genetic factors in obsessive-compulsive disorder in Latin Americans

  This study is looking at how genes might influence the chances of developing obsessive-compulsive disorder (OCD) in people from Latin America, and it's for anyone with OCD who wants to help us learn more about the condition to improve future treatments and support.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10885985

• Evaluating a treatment for veterans with obsessive-compulsive disorder

  This study is looking at how well a therapy called Exposure and Response Prevention (ERP) works for veterans with obsessive-compulsive disorder (OCD) when delivered online, compared to a group that will receive Stress Management Training, to see which helps them feel better and function well in their daily lives.

  NIH research Michael E Debakey VA Medical Center · Houston, United States · NIH-10879793

• Understanding genetic factors in obsessive-compulsive disorder in Latin Americans

  This study is looking at how genes might influence the risk of developing obsessive-compulsive disorder (OCD) in people from Latin America, and it's for anyone with OCD who wants to help us learn more about the condition to improve future treatments and support.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10851757

Related topics

Quick answers

How many Obsessive-Compulsive Disorder clinical trials are recruiting right now?

79, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (32 trials), China (11 trials), Sweden (5 trials), Canada (4 trials), France (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10, Phase 1/2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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