Understanding and improving fear responses in people with obsessive-compulsive disorder
Characterization and Modulation of Functional Connectivity and Fear Extinction Abnormalities in Obsessive-Compulsive Disorder
This study is looking at how people with obsessive-compulsive disorder (OCD) can learn to feel safer and how their brains might work differently, using a special technique to boost brain activity during therapy, all to find better ways to help those with OCD feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10944269 on NIH RePORTER |
What this research studies
This research investigates how individuals with obsessive-compulsive disorder (OCD) learn to feel safe and how their brain connections may be different from those without OCD. The study will use a technique called transcranial direct current stimulation (tDCS) to enhance brain activity in specific areas while patients undergo therapy. By examining these brain functions and their relationship to fear responses, the research aims to identify new ways to improve treatment outcomes for OCD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with obsessive-compulsive disorder.
Not a fit: Patients who do not have obsessive-compulsive disorder or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for individuals with OCD, helping them manage their symptoms better.
How similar studies have performed: Preliminary research has shown promise in using similar brain stimulation techniques to enhance safety learning in OCD patients, indicating potential for success in this approach.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Adams, Thomas G — University of Kentucky
- Study coordinator: Adams, Thomas G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.