Using deep transcranial magnetic stimulation to treat obsessive-compulsive disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of accelerated deep transcranial magnetic stimulation (dTMS) in treating patients with obsessive-compulsive disorder (OCD). Patients will be recruited from the Shanghai Mental Health Center and randomly assigned to either a real stimulation group or a sham stimulation group. The treatment involves administering dTMS twice daily for two weeks, with assessments conducted before and after treatment using EEG, MRI, cognitive tasks, and psychological scales to evaluate the treatment's impact and underlying neural mechanisms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged between 18 and 50, both genders are welcome.
* DSM-5 criteria for OCD.
* Y-BOCS total score ≥ 20 despite therapeutic-dose SRI treatment or completion of at least one full course of CBT. The treatment regimen must have been stable for at least 8 weeks prior to enrollment and remain unchanged throughout the study.
* More than 9 years of education.
* Right-handed.

Exclusion Criteria:

* Any additional current psychiatric comorbidity, except for obsessive- compulsive personality disorder.
* Severe obsessive symptoms prevent the completion of necessary assessments.
* Has a history of receiving ECT therapy.
* Has received rTMS or tDCS treatment within the past two months.
* Has severe physical illnesses or any physical conditions that can induce epilepsy or intracranial hypertension, including cardiovascular and respiratory diseases, among others.
* Has a past history of neurological disorders (such as epilepsy, cerebrovascular accidents, etc.) or brain injuries, or a history of brain surgery.
* Has implanted medical devices such as intracranial stents, cardiac pacemakers, coronary stents, cochlear implants, etc.
* Serious suicide risk.
* Pregnancy or nursing of an infant.

Where it's running

• Shanghai Mental Health Center
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Zhen Wang, PhD，MD — Study Principal Investigato
• Study coordinator: Zhen W Wang, PhD，MD
• Email: wangzhen@smhc.org.cn
• Phone: +86 34773516

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.