Using deep transcranial magnetic stimulation to treat obsessive-compulsive disorder
A Preliminary Study on the Efficacy and Influencing Factors of Deep Transcranial Magnetic Stimulation in the Treatment of Obsessive-compulsive Disorder
NA · Shanghai Mental Health Center · NCT06692114
This study is testing whether a new type of brain stimulation can help people with obsessive-compulsive disorder feel better.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Shanghai Mental Health Center (other) |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06692114 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of accelerated deep transcranial magnetic stimulation (dTMS) in treating patients with obsessive-compulsive disorder (OCD). Patients will be recruited from the Shanghai Mental Health Center and randomly assigned to either a real stimulation group or a sham stimulation group. The treatment involves administering dTMS twice daily for two weeks, with assessments conducted before and after treatment using EEG, MRI, cognitive tasks, and psychological scales to evaluate the treatment's impact and underlying neural mechanisms.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 50 with a diagnosis of OCD who have not adequately responded to standard treatments.
Not a fit: Patients with additional psychiatric disorders or severe physical illnesses that could interfere with treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with OCD who have not responded to traditional therapies.
How similar studies have performed: Previous studies have shown promising results with deep transcranial magnetic stimulation for various psychiatric conditions, suggesting potential efficacy in OCD as well.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged between 18 and 50, both genders are welcome. * DSM-5 criteria for OCD. * Y-BOCS total score ≥ 20 despite therapeutic-dose SRI treatment or completion of at least one full course of CBT. The treatment regimen must have been stable for at least 8 weeks prior to enrollment and remain unchanged throughout the study. * More than 9 years of education. * Right-handed. Exclusion Criteria: * Any additional current psychiatric comorbidity, except for obsessive- compulsive personality disorder. * Severe obsessive symptoms prevent the completion of necessary assessments. * Has a history of receiving ECT therapy. * Has received rTMS or tDCS treatment within the past two months. * Has severe physical illnesses or any physical conditions that can induce epilepsy or intracranial hypertension, including cardiovascular and respiratory diseases, among others. * Has a past history of neurological disorders (such as epilepsy, cerebrovascular accidents, etc.) or brain injuries, or a history of brain surgery. * Has implanted medical devices such as intracranial stents, cardiac pacemakers, coronary stents, cochlear implants, etc. * Serious suicide risk. * Pregnancy or nursing of an infant.
Where this trial is running
Shanghai, Shanghai Municipality
- Shanghai Mental Health Center — Shanghai, Shanghai Municipality, China (RECRUITING)
Study contacts
- Principal investigator: Zhen Wang, PhD，MD — Study Principal Investigato
- Study coordinator: Zhen W Wang, PhD，MD
- Email: wangzhen@smhc.org.cn
- Phone: +86 34773516
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obsessive-Compulsive Disorder, deep transcranial magnetic stimulation