Digital Mindfulness Therapy for Obsessive-Compulsive Disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial will enroll 150 participants with obsessive-compulsive disorder and assign them equally to three groups: digital mindfulness-based therapy (MBT) alone, routine pharmacological treatment, or MBT plus pharmacological treatment. The MBT is delivered via a mobile mini-program with video and audio lessons, guided practices, supervised weekly learning, and home exercises over six weeks. Participants will be assessed at baseline, during the 6-week program, and at 1, 3, 6, and 12 months to measure changes in OCD symptom severity and explore potential psychological and neurophysiological mechanisms. The study will examine whether MBT can provide an accessible, standardized psychological intervention either as a standalone treatment or in combination with medication.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. A primary diagnosis of obsessive-compulsive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).
2. Aged 12 to 65 years.
3. Primary school education or above and able to understand the study procedures and complete the required assessments.
4. Willing and able to provide written informed consent. For participants under 18 years of age, written informed consent will also be obtained from a parent or legal guardian.
5. Participants who are already receiving psychotropic medication must have maintained a stable medication regimen for at least 4 weeks before enrollment. Any clinically necessary medication changes during the study will be documented.

Exclusion Criteria:

1. Current or lifetime diagnosis of schizophrenia spectrum disorder, bipolar disorder, substance use disorder, or personality disorder.
2. Severe physical illness or central nervous system disease that may interfere with participation in the study.
3. Severe suicidal ideation or suicidal behavior within the past month.
4. Pregnancy, planned pregnancy, or breastfeeding.
5. Concurrent participation in another psychotherapy program or clinical trial.
6. Mindfulness practice within the past month.
7. Inability to understand or comply with the study procedures.

Where it's running

• The Second Xiangya Hospital of Central South University
  Changsha, Hunan, China Recruiting
• The Third Xiangya Hospital of Central South University
  Changsha, Hunan, China Recruiting

Study contacts

• Study coordinator: Chen Pan, Dr
• Email: 758933968@qq.com
• Phone: 86-0731-88618487

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Low-intensity focused ultrasound targeting the subthalamic nucleus for OCD

  A short test is being done to see if a wearable, non-invasive ultrasound device can safely and tolerably help adults with OCD by targeting a brain region called the subthalamic nucleus.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT07887633

• Mindfulness-Based Cognitive Therapy for OCD Delivered Online

  This study tests a synchronous online MBCT program for adults with OCD to see if it is acceptable and feasible and to explore links between biological markers, OCD severity, and treatment response.

  Recruiting IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia · NCT07834567

• Targeted brain stimulation for OCD: test of tTIS on nucleus accumbens

  This study tests whether targeted temporal interference stimulation of the nucleus accumbens can help reduce obsessive-compulsive symptoms in adults with OCD, compared with sham stimulation.

  Recruiting Beijing HuiLongGuan Hospital · Hefei, Anhui · NCT07805200

• Anxiety Skills Study: See if video skill training plus therapy helps people with anxiety

  This study tests whether a brief video-based skill training can help people with anxiety as well as four therapy sessions, and how durable the effects are over a year.

  Recruiting Ohio State University · Columbus, Ohio · NCT07774481

• AttunE LIFU for OCD: a non-invasive brain stimulation study

  This trial tests ATTN201, a wearable ultrasound headband, to see if it helps adults with OCD compared to a sham treatment.

  Recruiting Phase 2 University of Pennsylvania · San Francisco, California · NCT07728994

• Combined ERP and Habit Reversal Therapy for Tourettic OCD

  This study tests whether a merged Exposure and Response Prevention and Habit Reversal Therapy helps adults with Tourettic OCD more than either therapy alone or basic psychoeducation.

  Recruiting at 2 sites University College London Hospitals · London, London and 1 other locations · NCT07725926

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.