Investigating the cholinergic system's role in Obsessive Compulsive Disorder
Exploratory study of the cholinergic system in Obsessive Compulsive Disorder (OCD)
This study is looking at how a part of the brain that uses a chemical called acetylcholine might be linked to obsessive-compulsive disorder (OCD) by using mice that show similar behaviors, with the hope of finding new ways to help people with OCD feel better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11109641 on NIH RePORTER |
What this research studies
This research explores the connection between the cholinergic system and Obsessive Compulsive Disorder (OCD) by examining specific mouse models that exhibit OCD-like symptoms. Researchers will analyze the density of cholinergic interneurons and the release of acetylcholine in the striatum, which may contribute to compulsive behaviors. The study aims to identify new targets for treatment by understanding how alterations in the cholinergic system affect OCD symptoms. If successful, this research could lead to novel therapeutic approaches for individuals suffering from OCD.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are diagnosed with Obsessive Compulsive Disorder.
Not a fit: Patients who do not have a diagnosis of Obsessive Compulsive Disorder or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new treatment options for patients with Obsessive Compulsive Disorder.
How similar studies have performed: While the specific approach of targeting the cholinergic system in OCD is novel, similar research has shown promise in other disorders, indicating potential for success.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Abi-Dargham, Anissa — State University New York Stony Brook
- Study coordinator: Abi-Dargham, Anissa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.