Using rTMS on the Orbito Frontal Cortex for Obsessive-Compulsive Disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of repetitive Trans-cranial Magnetic Stimulation (rTMS) targeting the lateral part of the Orbito Frontal Cortex (lOFC) in patients diagnosed with Obsessive-Compulsive Disorder (OCD). Participants, aged 18-65, must have previously failed to respond to at least two different pharmacological treatments. The study aims to assess the efficacy of this non-invasive brain stimulation technique in alleviating OCD symptoms. The trial will be conducted at multiple locations, including Sorbonne University and Pitié-Salpêtrière Hospital in Paris.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: Participants will be both males and females, 18-65 years of age included.
* diagnosis of OCD
* all the patients must have failed to respond to at least two different pharmacological treatment used for at least 6 weeks
* Affiliation to a social security system (recipient or assignee),
* Signed written inform consent form

Exclusion Criteria:

* The exclusion criteria are a diagnosis of another psychiatric disorder (except for anxious disorders), a diagnosis of a significant active medical illness, pregnancy or other neurological illness
* In accordance with the safety criteria for rTMS, patients with a history of seizure or bearing pacemakers, mobile metal implants, implanted medical pumps, or metal clips placed inside the skull will also be excluded
* The patients won't be allowed to change their medication during the trial. The treatment must be stable at least 3 week before day 0.
* Female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception or who is nursing,
* Patient under curators
* Patient hospitalized under duress
* Patient unable to give his or hers informed consent

Where it's running

• Sorbonne University, Pitié-Salpêtrière Hospital
  Paris, France Recruiting
• Centre Hospitalier Henri Laborit
  Poitiers, France Recruiting

Study contacts

• Study coordinator: Ghina Harika-Germaneau, MD, PhD
• Email: ghina.harika.germaneau@ch-poitiers.fr
• Phone: +33 5 16 52 61 18

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.