Using nitrous oxide to treat obsessive-compulsive disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study investigates the efficacy of nitrous oxide, a commonly used inhaled anesthetic, in providing rapid symptom relief for individuals suffering from obsessive-compulsive disorder (OCD). The study aims to determine if a single inhalation of nitrous oxide can significantly improve OCD symptoms in participants aged 18 to 65 with a primary diagnosis of the disorder. Participants will be monitored for safety and effectiveness, with a focus on the severity of their symptoms before and after treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-65
* Primary diagnosis of OCD
* Sufficient severity of OCD symptoms
* Ability to tolerate a treatment-free period
* Capacity to provide informed consent

Exclusion Criteria:

* Psychiatric or medical conditions that make participation unsafe
* Pregnant or nursing females
* Concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)

Where it's running

• Stanford University
  Stanford, California, United States Recruiting

Study contacts

• Principal investigator: Peter J van Roessel, MD, PhD — Stanford Univeristy
• Study coordinator: Pavithra Mukunda, MS
• Email: ocdresearch@stanford.edu
• Phone: 650-723-4095

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Low-intensity focused ultrasound targeting the subthalamic nucleus for OCD

  A short test is being done to see if a wearable, non-invasive ultrasound device can safely and tolerably help adults with OCD by targeting a brain region called the subthalamic nucleus.

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• Mindfulness-Based Cognitive Therapy for OCD Delivered Online

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• Targeted brain stimulation for OCD: test of tTIS on nucleus accumbens

  This study tests whether targeted temporal interference stimulation of the nucleus accumbens can help reduce obsessive-compulsive symptoms in adults with OCD, compared with sham stimulation.

  Recruiting Beijing HuiLongGuan Hospital · Hefei, Anhui · NCT07805200

• Anxiety Skills Study: See if video skill training plus therapy helps people with anxiety

  This study tests whether a brief video-based skill training can help people with anxiety as well as four therapy sessions, and how durable the effects are over a year.

  Recruiting Ohio State University · Columbus, Ohio · NCT07774481

• AttunE LIFU for OCD: a non-invasive brain stimulation study

  This trial tests ATTN201, a wearable ultrasound headband, to see if it helps adults with OCD compared to a sham treatment.

  Recruiting Phase 2 University of Pennsylvania · San Francisco, California · NCT07728994

• Combined ERP and Habit Reversal Therapy for Tourettic OCD

  This study tests whether a merged Exposure and Response Prevention and Habit Reversal Therapy helps adults with Tourettic OCD more than either therapy alone or basic psychoeducation.

  Recruiting at 2 sites University College London Hospitals · London, London and 1 other locations · NCT07725926

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.