Understanding genetic factors in obsessive-compulsive disorder in Latin Americans
Official title: 1/2 Trans-ancestry genomic analysis of obsessive-compulsive disorder
Funded at Univ of North Carolina Chapel Hill · NIH-10885985 · Data updated 2026-11-12
This study is looking at how genes might influence the chances of developing obsessive-compulsive disorder (OCD) in people from Latin America, and it's for anyone with OCD who wants to help us learn more about the condition to improve future treatments and support.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $362,266 |
| NIH project number | 5U01MH125050-04 |
| Project ID | NIH-10885985 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with obsessive-compulsive disorder, particularly those from Latin American backgrounds.
✕Less likely to help
Patients who do not have obsessive-compulsive disorder or are not of Latin American descent may not benefit from this research.
What this research studies
This research investigates how genetic factors contribute to the risk of developing obsessive-compulsive disorder (OCD) among individuals in Latin America. By collecting a diverse sample of 5,000 OCD cases from various clinics across Latin America and the USA, the study aims to enhance our understanding of the genetic architecture of OCD. Participants will undergo detailed clinical assessments to characterize their symptoms and any comorbid conditions. The findings could lead to improved detection, treatment, and prevention strategies for OCD based on genetic insights.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and prevention strategies for obsessive-compulsive disorder tailored to the genetic backgrounds of patients.
How similar studies have gone: Previous research in other psychiatric disorders has shown success in using genomic analysis to uncover genetic factors, suggesting potential for similar breakthroughs in OCD.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Crowley, James Joseph — Univ of North Carolina Chapel Hill
- Study coordinator: Crowley, James Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.