Study on how genetics and microbiome affect OCD treatment with SSRIs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the relationship between genetic variants, microbiome, and the response to selective serotonin reuptake inhibitors (SSRIs) in patients with obsessive-compulsive disorder (OCD). It will recruit 200 drug-naive or drug-free participants aged 19 to 70, who will receive SSRIs tailored to their individual needs. Evaluations will be conducted at baseline, 4 months, 6 months, and 1 year after treatment using various psychological scales and functional MRI for some participants. Blood samples will be collected for genetic, proteomic, and microbiomic analyses to explore predictors of treatment response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. age 19\~ 70
2. OCD by Diagnostic and Statistical Manual for Mental disorders, 4th edition (DSM-IV)
3. drug naive or drug free for more than 3 months

Exclusion Criteria:

1. any neurological disorder
2. comorbid psychotic disorders
3. alcohol or other substance dependence within past 6 months
4. any evidences for brain diseases

Where it's running

• Yonsei Univ. Health System Severance Hospital
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Se Joo Kim, M.D. — Professor, Department of Psychiactry, Yonsei Univ. College of Medicine
• Study coordinator: Se Joo Kim, M.D.
• Email: kimsejoo@yuhs.ac
• Phone: +82-2-2228-1627

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.