Glucose Consumption During Deep Brain Stimulation With Functional [18F]FDG-Brain-PET in Obsessive-Compulsive Disorder
This study is testing how the brain uses sugar during deep brain stimulation to see if it helps people with obsessive-compulsive disorder.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 8 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 1 site (Vienna, State of Vienna) |
| Trial ID | NCT05577598 on ClinicalTrials.gov |
What this trial studies
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Who should consider this trial
Good fit: Unknown
Not a fit: Unknown
Why it matters
Potential benefit: Unknown
How similar studies have performed: Unknown
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * a score of 25 or higher on the Yale-Brown Obsessive Compulsive Scale * previous failure to respond to at least two medication trials with serotonin reuptake inhibitors at or, if tolerated, beyond the FDA maximum recommended dose for a minimum duration over at least ten weeks each. * at least one trial with tricyclic medication at or, if tolerated, beyond the FDA maximum recommended dose for a minimum duration over at least ten weeks each. * at least one trial of augmentation with antipsychotic medication, lithium, a benzodiazepine or buspirone * at least on trial of psychotherapy (cognitive behavioral therapy or comparable techniques) for at least 20 sessions * ability to provide written informed consent Exclusion Criteria: * any history of current or past psychotic disorder * a manic episode within the preceding three years * any current clinically significant medical or neurological disorder, that is a contraindication against DBS * any disease that could lead to an altered glucose reactivity (e.g. diabetes) * any clinically significant preoperative MRI abnormality or inability to undergo presurgical MRI * current or unstable remitted substance abuse or dependence except nicotine * pregnancy or high risk of becoming pregnant during study duration (desire to have children) and refusal to utilize a proper method of contraception * Any current severe personality disorder except comorbid anankastic personality disorder * Inability to follow the study protocol or adhere to operational requirements * Current and unstable suicidality
Where this trial is running
Vienna, State of Vienna
- Medical University of Vienna, Department of Psychiatry and Psychotherapy — Vienna, State of Vienna, Austria (Recruiting)
Study contacts
- Principal investigator: Christoph Kraus, MD PhD — Medical University of Vienna, Department of Psychiatry and Psychotherapy
- Study coordinator: Christoph Kraus, MD PhD
- Email: christoph.kraus@muv.ac.at
- Phone: +43 1 40400 73882
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions
Obsessive-Compulsive DisorderPsychiatric DisorderFDG-PETDeep Brain StimulationBrain Glucose Consumption
Last reviewed 2026-06-09 by the Find a Trial editorial team.
Information on this page is for educational purposes and is not medical advice.
Always consult qualified healthcare professionals about clinical trial participation.