Understanding the brain mechanisms behind obsessive-compulsive disorder
Official title: Neurocomputational mechanisms and connectivity dynamics underlying obsessive-compulsive disorder and phenotypical differentiations
Funded at Icahn School of Medicine at Mount Sinai · NIH-11111451 · Data updated 2026-11-12
This study is looking at how the brain works in people with obsessive-compulsive disorder (OCD) to better understand their symptoms and improve treatment options, using advanced brain scans and computer models to see how different parts of the brain are connected and make decisions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 10, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $717,470 |
| NIH project number | 5R01MH133625-02 |
| Project ID | NIH-11111451 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with obsessive-compulsive disorder who experience significant symptoms.
✕Less likely to help
Patients without a diagnosis of obsessive-compulsive disorder or those with other unrelated psychiatric conditions may not benefit from this research.
What this research studies
This research investigates the neural and computational mechanisms that contribute to obsessive-compulsive disorder (OCD), a condition characterized by intrusive thoughts and compulsive behaviors. By analyzing brain connectivity and decision-making processes through advanced neuroimaging techniques, the study aims to differentiate between various OCD symptoms and improve diagnostic accuracy. The researchers will utilize fMRI data and computational models to explore how specific brain circuits are involved in the rigidity of thoughts and behaviors associated with OCD. This innovative approach seeks to provide insights that could lead to more effective treatments for patients suffering from this disorder.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for individuals with obsessive-compulsive disorder.
How similar studies have gone: Previous research has shown promise in using neuroimaging and computational models to understand psychiatric disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Fiore, Vincenzo Guido — Icahn School of Medicine at Mount Sinai
- Study coordinator: Fiore, Vincenzo Guido
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.