Understanding the brain mechanisms behind obsessive-compulsive disorder
Neurocomputational mechanisms and connectivity dynamics underlying obsessive-compulsive disorder and phenotypical differentiations
This study is looking at how the brain works in people with obsessive-compulsive disorder (OCD) to better understand their symptoms and improve treatment options, using advanced brain scans and computer models to see how different parts of the brain are connected and make decisions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11111451 on NIH RePORTER |
What this research studies
This research investigates the neural and computational mechanisms that contribute to obsessive-compulsive disorder (OCD), a condition characterized by intrusive thoughts and compulsive behaviors. By analyzing brain connectivity and decision-making processes through advanced neuroimaging techniques, the study aims to differentiate between various OCD symptoms and improve diagnostic accuracy. The researchers will utilize fMRI data and computational models to explore how specific brain circuits are involved in the rigidity of thoughts and behaviors associated with OCD. This innovative approach seeks to provide insights that could lead to more effective treatments for patients suffering from this disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with obsessive-compulsive disorder who experience significant symptoms.
Not a fit: Patients without a diagnosis of obsessive-compulsive disorder or those with other unrelated psychiatric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for individuals with obsessive-compulsive disorder.
How similar studies have performed: Previous research has shown promise in using neuroimaging and computational models to understand psychiatric disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Fiore, Vincenzo Guido — Icahn School of Medicine at Mount Sinai
- Study coordinator: Fiore, Vincenzo Guido
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.