New treatment approach for obsessive-compulsive disorder
Official title: Towards Remission and Full Recovery From Obsessive-compulsive Disorder: Investigating the Efficacy of Inference-Based Cognitive-Behavioral Therapy When Standard Treatment Has Failed
Run by Ciusss de L'Est de l'Île de Montréal · NCT06318806 · Data updated 2026-11-12
This study is testing whether a new therapy called Inference-based Cognitive Behavioral Therapy can help people with obsessive-compulsive disorder feel better compared to the usual treatment they’ve already tried.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 160 (estimated) |
| Sponsor | Ciusss de L'Est de l'Île de Montréal Academic / other |
| Locations | 1 site (Montreal, Quebec) |
| Status | Recruiting |
| Started | July 1, 2024 |
| Main results expected | September 30, 2029 |
| Study ends | September 30, 2029 |
| Registry record updated | July 8, 2024 |
| Trial ID | NCT06318806 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older with a primary diagnosis of OCD who have not achieved remission after initial ERP treatment.
✕Probably not a fit
Patients with severe suicidal ideation, psychotic disorders, or those currently undergoing other psychological treatments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial focuses on improving treatment outcomes for patients with obsessive-compulsive disorder (OCD) by comparing two therapeutic approaches: Exposure and Response Prevention (ERP) and Inference-based Cognitive Behavioral Therapy (I-CBT). The study will involve a randomized controlled trial with 160 patients who have not achieved remission after an initial ERP treatment. Participants will be assessed for OCD severity using standardized measures, and the effectiveness of I-CBT will be evaluated against continued ERP treatment. The goal is to determine if I-CBT offers superior outcomes for those who struggle with traditional ERP methods.
Why it matters
Potential benefit: If successful, this study could provide a more effective and acceptable treatment option for patients with OCD who do not respond to standard therapies.
How similar studies have gone: Previous studies have shown promise for I-CBT in treating OCD, suggesting that this approach may be more effective for certain patient subgroups compared to traditional methods.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: 1. a primary diagnosis of OCD according to DSM-5 criteria. 2. a score ≥ 18 on the Y-BOCS 3. age ≥ 18. 4. no change in medication during the 8 weeks before treatment for antidepressants (4 weeks for anxiolytics). 5. willingness to keep medication stable while participating in the study. 6. not undergoing a concurrent psychological treatment. 7. access to a computer or phone with internet access. Exclusion criteria: 8. evidence of a high level of suicidal ideation, suicidal intent or previous suicide attempts. 9. past or present psychotic or bipolar disorder. 10. neurocognitive disorder, pervasive developmental disorder or intellectual disability of a severity judged to significantly interfere with treatment and/or requiring treatment first. 11. substance abuse disorder of a severity judged to significantly interfere with treatment and/or requiring treatment first.
Where it's running
-
Institut universitaire en santé mentale de Montréal
Montreal, Quebec, Canada Recruiting
Study contacts
- Principal investigator: Frederick Aardema, PhD — Institut universitaire en santé mentale de Montréal
- Study coordinator: Frederick Aardema, PhD
- Email: faardema@gmail.com
- Phone: 514-662-5116
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.