Investigating rare genetic variations linked to obsessive-compulsive disorder
Official title: 1/2 Rare Genetic Variation and Risk for Obsessive Compulsive Disorder
Funded at Icahn School of Medicine at Mount Sinai · NIH-10976441 · Data updated 2026-11-12
This study is looking at how certain rare genetic changes might affect the chances of developing obsessive-compulsive disorder (OCD), and it's for people with OCD and their families to help improve understanding and treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 15, 2020 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $445,599 |
| NIH project number | 5R01MH124679-05 |
| Project ID | NIH-10976441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with obsessive-compulsive disorder, particularly those under the age of 11.
✕Less likely to help
Patients without a diagnosis of obsessive-compulsive disorder or those over the age of 11 may not benefit from this research.
What this research studies
This research aims to explore how rare genetic variations in protein-coding genes may influence the risk of developing obsessive-compulsive disorder (OCD). By utilizing whole exome sequencing (WES) from a large cohort of OCD patients and matched controls, the study seeks to identify specific genetic factors associated with OCD. The research will involve collecting genetic data from over 5,100 OCD subjects and 3,000 controls from Sweden and Norway, which will be combined with existing data to enhance the understanding of OCD's genetic architecture. This could lead to improved detection, treatment, and prevention strategies for OCD based on genetic insights.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with obsessive-compulsive disorder.
How similar studies have gone: Previous research in other psychiatric disorders using whole exome sequencing has shown success in identifying genetic factors, suggesting a promising approach for OCD as well.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Grice, Dorothy E — Icahn School of Medicine at Mount Sinai
- Study coordinator: Grice, Dorothy E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.