Condition

Generalized Anxiety Disorder clinical trials and research

• 45Clinical trials
• 4NIH research projects
• 19Countries

Newest Generalized Anxiety Disorder clinical trials

All recruiting trials (45)

• Adjunctive JNJ-99245354 for Generalized Anxiety Disorder (GAD)

  This study tests whether adding JNJ-99245354 to existing GAD treatment helps reduce anxiety more than a placebo for adults with GAD who didn’t get adequate benefit from previous treatments.

  Recruiting at 4 sites Phase 3 Intra-Cellular Therapies, Inc. · Temecula, California and 3 other locations · NCT07856420

• Testing ITI-1284 for Generalized Anxiety Disorder (GAD)

  This phase 3 trial tests whether ITI-1284 is safe and tolerable when taken alone or with other medicines by adults with generalized anxiety disorder who haven’t responded to prior treatment.

  Recruiting at 3 sites Phase 3 Intra-Cellular Therapies, Inc. · Los Angeles, California and 2 other locations · NCT07807865

• Long-term safety and tolerability of SEP-363856 in adults with generalized anxiety disorder

  In adults with generalized anxiety disorder, this Phase 3 open-label extension tests whether continuing SEP-363856 at 50 mg or 75 mg daily for 26 weeks is safe, tolerable, and possibly helpful.

  Recruiting at 2 sites Phase 3 Otsuka Pharmaceutical Development & Commercialization, Inc. · Jacksonville, Florida and 1 other locations · NCT07786454

• Anxiety Skills Study: See if video skill training plus therapy helps people with anxiety

  This study tests whether a brief video-based skill training can help people with anxiety as well as four therapy sessions, and how durable the effects are over a year.

  Recruiting Ohio State University · Columbus, Ohio · NCT07774481

• Continuous Theta Burst Stimulation for Generalized Anxiety Disorder (cTBS for GAD)

  This study tests whether applying continuous theta burst stimulation to the right posterior parietal cortex or the right dorsolateral prefrontal cortex helps adults with generalized anxiety disorder.

  Recruiting Military Hospital 175 · Ho Chi Minh City · NCT07770919

• Fixed-dose SEP-363856 vs placebo for adults with generalized anxiety disorder

  This trial tests whether a fixed 75 mg/day dose of SEP-363856 helps adults with generalized anxiety disorder more than placebo over 8 weeks.

  Recruiting at 11 sites Phase 3 Otsuka Pharmaceutical Development & Commercialization, Inc. · Redlands, California and 10 other locations · NCT07767903

• Fixed-dose SEP-363856 for Generalized Anxiety Disorder

  A large, global study will test whether daily doses of SEP-363856 (50 mg or 75 mg) help adults with generalized anxiety disorder more than a placebo over 8 weeks.

  Recruiting at 17 sites Phase 3 Otsuka Pharmaceutical Development & Commercialization, Inc. · Tucson, Arizona and 16 other locations · NCT07759128

• LIFU for Chronic Pain and Generalized Anxiety Disorder

  A small, one-arm study will test whether accelerated low-intensity focused ultrasound can help people with chronic pain or generalized anxiety disorder.

  Recruiting Virginia Polytechnic Institute and State University · Roanoke, Virginia · NCT07686354

• Student Precarity and Psychiatry: How Financial Struggles Relate to Depression and Loneliness

  This observational study looks at whether financial hardship and social isolation are linked to depression, suicidal thoughts, and loneliness among French university students.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, IDF · NCT07618208

• Group versus individual metacognitive therapy for generalized anxiety disorder

  This study will see if group-based metacognitive therapy works as well as individual metacognitive therapy for adults with generalized anxiety disorder who score 10 or higher on the GAD-7.

  Recruiting at 2 sites Sorlandet Hospital HF · Kristiansand, Agder and 1 other locations · NCT07579897

• RE104 for Injection in Generalized Anxiety Disorder

  A study to see if a single or repeat dose of RE104 helps reduce anxiety symptoms in adults with Generalized Anxiety Disorder compared to a placebo.

  Recruiting at 27 sites Phase 2 Reunion Neuroscience Inc · Birmingham, Alabama and 27 other locations · NCT07489651

• SYT-510 in Generalized Anxiety Disorder: a single-dose test vs placebo

  This study tests a single dose of SYT-510 to see if it helps people with generalized anxiety disorder more than a placebo, while checking safety and how the drug behaves in the body.

  Recruiting Phase 2 Synendos Therapeutics AG · London · NCT07478744

• Electroacupuncture as an add-on to SSRI treatment for generalized anxiety disorder

  This study tests whether adding electroacupuncture helps people with generalized anxiety disorder who are already taking an SSRI medication.

  Recruiting First People's Hospital of Hangzhou · Hangzhou, Zhejiang · NCT07392645

• Metacognitive Therapy vs Cognitive-Behavioral Therapy for Anxiety Disorders

  This study asks people with generalized anxiety disorder, social anxiety disorder, or PTSD to share their experiences after trying metacognitive therapy or disorder-specific cognitive-behavioral therapy in a randomized trial.

  Recruiting Karolinska Institutet · Stockholm · NCT07382323

• Crisugabalin capsules for adults with generalized anxiety disorder

  This trial will test whether 40 mg/day of Crisugabalin reduces anxiety symptoms in adults with generalized anxiety disorder compared with venlafaxine and placebo.

  Recruiting Phase 2 Anhui Medical University · Hefei, Anhui · NCT07330648

• Long-term mental health tracking for medical students

  This project will try to find what makes medical students more likely to develop depression by following cohorts of first-year health students over time and comparing them with peers who did not progress to the second year.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans, Loiret · NCT07305701

• Navigated cTBS treatment for generalized anxiety disorder

  This will test whether neuronavigation-guided continuous theta burst stimulation (cTBS) to a specific brain area can reduce anxiety in adults with generalized anxiety disorder.

  Recruiting at 2 sites Anhui Medical University · Hefei, Anhui and 1 other locations · NCT07121712

• Teletherapy versus in-person third-wave CBT for generalized anxiety disorder

  This trial will test whether weekly teletherapy works as well as face-to-face third-wave cognitive behavioral therapy for adults aged 18–45 in Pakistan with generalized anxiety disorder.

  Recruiting Government College University Faisalabad · Faisalabad, Punjab Province · NCT07119515

• Mindful Self-Compassion delivered in person versus by video for anxiety and depression

  This project will see if an 8-week Mindful Self-Compassion class delivered in person or by video helps people with anxiety or depression have fewer symptoms.

  Recruiting Georgetown University · Washington D.C., District of Columbia · NCT07028216

• Stepped versus stratified care for anxiety in children and adolescents

  This project tests whether starting all 8–17-year-olds with anxiety on online CBT and adding in-person CBT only if needed (stepped care) works as well as assigning online or in-person CBT up front based on clinical complexity (stratified care).

  Recruiting Region Skane · Lund · NCT06942429

• Team-delivered exposure-based CBT for children and teens with anxiety and OCD

  This test tries three ways of delivering team-based exposure-focused CBT—in-person, by telehealth, or a flexible mix—to see which works best for kids and teens (ages 5–18) with anxiety or OCD.

  Recruiting Bradley Hospital · East Providence, Rhode Island · NCT06934525

• Ultra-brief and brief transdiagnostic cognitive-behavioral therapy for emotional symptoms

  This trial tests whether four-session and eight-session transdiagnostic cognitive-behavioral treatments can help adults with mild to moderate depression, anxiety, or related emotional symptoms compared with a relaxation control.

  Recruiting at 2 sites Universidad de Córdoba · Córdoba, Córdoba and 1 other locations · NCT06909669

• Comparing Psychoanalytic Therapy and Cognitive Behavioral Therapy for Generalized Anxiety Disorder

  This study is testing whether short-term psychoanalytic therapy or Cognitive Behavioral Therapy (CBT) works better for adults with Generalized Anxiety Disorder.

  Recruiting Beykoz University · Istanbul · NCT06831708

• Internet-based treatment for anxiety and depression in adolescents

  This study is testing an online treatment for anxiety and depression in Romanian teenagers aged 13-17 to see if it helps them feel better and to find out which teens are most likely to benefit from it.

  Recruiting Babes-Bolyai University · Cluj-Napoca and 1 other locations · NCT06724666

• Treatment for Generalized Anxiety Disorder with ITI-1284

  This study is testing whether a new medication called ITI-1284 can help people with Generalized Anxiety Disorder who haven't found relief from other treatments.

  Recruiting at 49 sites Phase 2 Intra-Cellular Therapies, Inc. · Birmingham, Alabama and 50 other locations · NCT06701903

• Online cognitive behavioral therapy for children and adolescents with anxiety

  This project will test whether an internet-delivered CBT program can help children and teens with anxiety feel less anxious.

  Recruiting Lund University · Kalmar, Region Kalmar Län · NCT06661460

• Neurofeedback-enhanced cognitive reappraisal training for young adults with anxiety

  This trial uses real-time fMRI neurofeedback to see if training the brain can help young adults with anxiety improve their emotion regulation and reappraisal skills.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06563310

• Evaluating ITI-1284 for treating Generalized Anxiety Disorder

  This study is testing a new medication called ITI-1284 to see if it can help people with Generalized Anxiety Disorder who haven't found relief from their current treatments.

  Recruiting at 59 sites Phase 2 Intra-Cellular Therapies, Inc. · Glendale, California and 58 other locations · NCT06480383

• Exploring new brain stimulation targets for mental health conditions

  This study is testing how a brain stimulation treatment can help people with depression, anxiety, OCD, and schizophrenia by looking at changes in their brain and behavior.

  Recruiting Phase 2 Brigham and Women's Hospital · Sunnyvale, California and 1 other locations · NCT06376734

• Trigeminal nerve stimulation for treatment-resistant anxiety

  This study is testing if trigeminal nerve stimulation can help people with treatment-resistant anxiety feel better while they continue their usual medication.

  Recruiting Queen's University · Kingston, Ontario · NCT06278909

• Treatment of Generalized Anxiety Disorder with Buagafuran Capsules

  This study is testing if Buagafuran capsules can help people with Generalized Anxiety Disorder feel better compared to a placebo over 8 weeks.

  Recruiting Phase 3 Beijing Union Pharmaceutical Factory Ltd · Beijing, Beijing Municipality · NCT06243640

• Treatment of Generalized Anxiety Disorder with Buagafuran Capsules

  This study is testing if Buagafuran capsules can help adults with Generalized Anxiety Disorder feel less anxious compared to a placebo and a standard treatment over eight weeks.

  Recruiting Phase 3 Beijing Union Pharmaceutical Factory Ltd · Beijing, Beijing Municipality · NCT06243614

• Using L-methylfolate to help patients with treatment-resistant anxiety

  This study is testing if adding L-methylfolate to the usual anxiety medications can help people with treatment-resistant generalized anxiety disorder feel better.

  Recruiting Phase 4 Queen's University · Kingston, Ontario · NCT06218030

• Survey to determine eligibility for psychiatry clinical trials

  This study is trying to see if people with conditions like depression, anxiety, or personality disorders can join upcoming psychiatry clinical trials.

  Recruiting at 6 sites Adams Clinical · Boston, Massachusetts and 5 other locations · NCT05800925

• Testing Shugan Jieyu Capsule for Generalized Anxiety Disorder

  This study is testing if Shugan Jieyu Capsules can help people with generalized anxiety disorder feel better compared to a placebo.

  Recruiting Phase 3 Chengdu Kanghong Pharmaceutical Group Co., Ltd. · Beijing · NCT05772104

• Mindful Self-Compassion training for anxiety and depression

  This study is testing if an 8-week Mindful Self-Compassion training program can help people with anxiety and depression feel better compared to those who don't take the training.

  Recruiting Georgetown University · Washington D.C., District of Columbia · NCT05671419

• Investigating risk and resilience factors in RCMP members

  This study is testing how different factors affect the mental health of new RCMP cadets, especially regarding posttraumatic stress, and whether training in emotional resilience can help them cope better.

  Recruiting University of Regina · Regina, Saskatchewan · NCT05527509

• Evaluating CO2 Reactivity to Predict Response to Exposure Therapy for Anxiety Disorders

  This study is testing whether measuring how people react to CO2 can help predict if adults with anxiety disorders will benefit from exposure therapy.

  Recruiting at 2 sites University of Texas at Austin · Boston, Massachusetts and 1 other locations · NCT05467683

• Comparing two therapies for treating anxiety disorders

  This study is testing two different therapies for anxiety to see which one helps people feel less anxious and improve their mental health better than just learning about anxiety.

  Recruiting University of Texas at Austin · Austin, Texas · NCT05427708

• Linking anxiety symptoms to deep brain activity

  This will try to see if brain recordings taken during presurgical monitoring in adults with drug‑resistant epilepsy reveal patterns tied to generalized anxiety disorder.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT05393518

• Computer-based therapy for anxiety and alcohol use disorders

  This study is testing a computer-based therapy for people with both anxiety and alcohol use disorders to see if it helps them feel better compared to standard treatment.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05117255

• Evaluating the impact of self-help CBT in primary care behavioral health

  This study is testing if adding guided self-help therapy to regular mental health care can help patients feel better and improve their daily lives.

  Recruiting at 2 sites Linnaeus University · Varberg, Halland County and 3 other locations · NCT04900064

• Mindfulness app for treating anxiety

  This study is testing a 14-day mindfulness app to see if it can help people with generalized anxiety disorder feel less anxious and improve their focus and social skills.

  Recruiting Penn State University · University Park, Pennsylvania · NCT04846777

• Self-guided online therapy for patients with anxiety disorders

  This study tests whether a self-guided online therapy program can help people with anxiety feel better while they wait for in-person therapy.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT04793828

• Using focused ultrasound to treat generalized anxiety disorder

  This study is testing whether a new ultrasound treatment can help people with generalized anxiety disorder who haven't found relief from regular medications.

  Recruiting at 3 sites University of California, Los Angeles · Los Angeles, California and 2 other locations · NCT04557891

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how heavy drinking and anxiety relate in emerging adults

  This grant studies how heavy alcohol use and anxiety symptoms interact in young adults (ages 18–34) and what biological stress markers might reveal about that relationship.

  NIH research Brown University · Providence, United States · NIH-11627893

• Cannabidiol-boosted therapy for generalized anxiety disorder

  A new project tests whether cannabidiol can boost the effectiveness of cognitive behavioral therapy for adults with generalized anxiety disorder.

  NIH research Wayne State University · Detroit, United States · NIH-11331990

• Using cannabidiol to improve cognitive behavioral therapy for anxiety

  This study is looking at whether adding cannabidiol, a safe part of cannabis, can make cognitive behavioral therapy (CBT) more effective for people with generalized anxiety disorder, helping them better manage their emotions and anxiety.

  NIH research Wayne State University · Detroit, United States · NIH-11124492

• Understanding how mindfulness helps people with anxiety and if it affects men and women differently

  This study is looking at how practicing mindfulness can help people with Generalized Anxiety Disorder by seeing how it affects their brain and emotions, and it will also check if men and women respond differently to these mindfulness techniques.

  NIH research New York University School of Medicine · New York, United States · NIH-11076334

Related topics

Quick answers

How many Generalized Anxiety Disorder clinical trials are recruiting right now?

45, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (21 trials), China (6 trials), Sweden (4 trials), France (3 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 8, Phase 2: 6, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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