Training to improve response inhibition in obsessive-compulsive disorders
Neural Mechanisms of Response Inhibition Training for Obsessive-Compulsive Disorder and Related Conditions
This study is testing a new computer training program to see if it can help people with obsessive-compulsive disorders, like OCD and skin picking, improve their ability to control their urges.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 118 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | University of Wisconsin, Milwaukee Academic / other |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Trial ID | NCT05377125 on ClinicalTrials.gov |
What this trial studies
This project investigates the effects of a novel computerized intervention called response inhibition training (RIT) on individuals with obsessive-compulsive and related disorders (OCRD), including OCD, trichotillomania, and skin picking disorder. Participants will be randomly assigned to either the RIT or a placebo training group, undergoing 8 to 16 sessions. The study aims to assess changes in neural indicators of response inhibition and their correlation with improvements in OCRD symptoms. By utilizing neurobehavioral measures and brain imaging, the research seeks to establish a mechanistic link between enhanced response inhibition and symptom reduction.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 60 with a primary diagnosis of OCD, trichotillomania, or skin picking disorder and moderate symptom severity.
Not a fit: Patients with current substance use disorders, severe ADHD, or other significant psychiatric conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could provide a new, effective treatment option for patients suffering from OCRDs by directly targeting and improving response inhibition deficits.
How similar studies have performed: While the approach of using computerized cognitive training for response inhibition is innovative, previous studies have indicated that addressing response inhibition deficits may be beneficial for similar conditions, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age between 18 and 60 * moderate level of OCRD symptoms (Yale-Brown Obsessive Compulsive Scale total ≥ 16, Massachusetts General Hospital-Hair pulling Scale total ≥ 12, or Skin Picking Scale-Revised total ≥ 7) * a primary diagnosis of OCRD (i.e., OCD, TTM, or SPD) * estimated IQ \> 80 * presence of a RI deficits (SSRT ≥ 215ms). Exclusion Criteria: * Current substance use disorder * Severe ADHD * Lifetime diagnosis of psychotic disorder, bipolar disorder, or schizophrenia * Current psychotherapy * Change in psychotropic medication status within 8 weeks before the study or during the study * Use of stimulant medication * Active suicidal risk * Contraindications for MRI procedures
Where this trial is running
Milwaukee, Wisconsin
- UWM Anxiety Disorders Laboratory — Milwaukee, Wisconsin, United States (Recruiting)
Study contacts
- Principal investigator: Hanjoo Lee, Ph.D. — University of Wisconsin, Milwaukee
- Study coordinator: Hanjoo Lee, Ph.D.
- Email: leehj@uwm.edu
- Phone: 414-229-5858
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.