Training to improve response inhibition in obsessive-compulsive disorders
Official title: Neural Mechanisms of Response Inhibition Training for Obsessive-Compulsive Disorder and Related Conditions
Run by University of Wisconsin, Milwaukee · NCT05377125 · Data updated 2026-11-12
This study is testing a new computer training program to see if it can help people with obsessive-compulsive disorders, like OCD and skin picking, improve their ability to control their urges.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 118 (estimated) |
| Sponsor | University of Wisconsin, Milwaukee Academic / other |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Status | Recruiting |
| Started | December 22, 2022 |
| Main results expected | July 31, 2027 |
| Study ends | August 31, 2027 |
| Registry record updated | August 10, 2026 |
| Trial ID | NCT05377125 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 to 60 with a primary diagnosis of OCD, trichotillomania, or skin picking disorder and moderate symptom severity.
✕Probably not a fit
Patients with current substance use disorders, severe ADHD, or other significant psychiatric conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project investigates the effects of a novel computerized intervention called response inhibition training (RIT) on individuals with obsessive-compulsive and related disorders (OCRD), including OCD, trichotillomania, and skin picking disorder. Participants will be randomly assigned to either the RIT or a placebo training group, undergoing 8 to 16 sessions. The study aims to assess changes in neural indicators of response inhibition and their correlation with improvements in OCRD symptoms. By utilizing neurobehavioral measures and brain imaging, the research seeks to establish a mechanistic link between enhanced response inhibition and symptom reduction.
Why it matters
Potential benefit: If successful, this intervention could provide a new, effective treatment option for patients suffering from OCRDs by directly targeting and improving response inhibition deficits.
How similar studies have gone: While the approach of using computerized cognitive training for response inhibition is innovative, previous studies have indicated that addressing response inhibition deficits may be beneficial for similar conditions, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age between 18 and 60 * moderate level of OCRD symptoms (Yale-Brown Obsessive Compulsive Scale total ≥ 16, Massachusetts General Hospital-Hair pulling Scale total ≥ 12, or Skin Picking Scale-Revised total ≥ 7) * a primary diagnosis of OCRD (i.e., OCD, TTM, or SPD) * estimated IQ \> 80 * presence of a RI deficits (SSRT ≥ 215ms). Exclusion Criteria: * Current substance use disorder * Severe ADHD * Lifetime diagnosis of psychotic disorder, bipolar disorder, or schizophrenia * Current psychotherapy * Change in psychotropic medication status within 8 weeks before the study or during the study * Use of stimulant medication * Active suicidal risk * Contraindications for MRI procedures
Where it's running
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UWM Anxiety Disorders Laboratory
Milwaukee, Wisconsin, United States Recruiting
Study contacts
- Principal investigator: Hanjoo Lee, Ph.D. — University of Wisconsin, Milwaukee
- Study coordinator: Hanjoo Lee, Ph.D.
- Email: leehj@uwm.edu
- Phone: 414-229-5858
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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A short test is being done to see if a wearable, non-invasive ultrasound device can safely and tolerably help adults with OCD by targeting a brain region called the subthalamic nucleus.
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This study tests whether a brief video-based skill training can help people with anxiety as well as four therapy sessions, and how durable the effects are over a year.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.