Mindfulness-Based Cognitive Therapy for OCD Delivered Online

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study recruits adults with OCD from two centers in Italy to participate in a group-based MBCT program delivered via videoconference. The trial will assess how acceptable and feasible the online, therapist-led MBCT approach is for OCD patients and how clinical measures relate to treatment response. Blood and saliva samples will be collected at one center for molecular analyses, with a matched healthy control group for comparison in secondary analyses. The MBCT program combines mindfulness practices with cognitive-behavioral strategies, exposure, and acceptance techniques implemented in a manualized format. Participants must have stable medication, be 18–45 years old, and have no recent mindfulness experience.

Why it matters

Who can join: the full rules

Patients with OCD.

Inclusion Criteria:

* Diagnosis of obsessive-compulsive disorder (OCD) according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)
* Age between 18 and 45 years
* Stable pharmacological treatment for at least 3 months prior to the start of the experimental intervention
* No previous experience with mindfulness meditation, or previous mindfulness meditation experience with no practice during the 12 months prior to study enrollment
* Ability and willingness to provide written informed consent.

Exclusion Criteria:

* Diagnosis of schizophrenia spectrum or other psychotic disorders, including schizoaffective disorder
* Diagnosis of bipolar and related disorders
* Major depressive disorder in an acute phase
* Active substance use disorder or alcohol use disorder as the primary diagnosis
* Personality disorders of clinically significant severity
* Documented major neurocognitive disorder. Neurological conditions or medical conditions with a clinically significant impact on cognitive or mental functioning
* Previous mindfulness meditation practice within the 12 months prior to study enrollment
* Inability or unwillingness to provide informed consent

Healthy subjects.

Inclusion Criteria:

* Age between 18 and 45 years, with age matching within a maximum difference of ±3 years from the corresponding index patient. In all cases, control participants must be at least 18 years and no older than 48 years
* Voluntary participation in the study.
* Ability and willingness to provide written informed consent

Exclusion criteria:

* Age younger than 18 years
* History of psychiatric disorders, as assessed using the Structured Clinical Interview for DSM-5 Disorders - Clinician Version (SCID-CV)
* Intellectual developmental disorder.
* Current substance use disorder or alcohol use disorder
* Neurological disorders, including Parkinson's disease, major neurocognitive disorders, neurodegenerative syndromes, ataxias, multiple sclerosis, cerebrovascular events (stroke or transient ischemic attack \[TIA\]), central nervous system neoplasms, epilepsy, history of seizures, or clinically significant tremor
* Systemic medical conditions (e.g., diabetes mellitus, atherosclerosis, chronic arterial hypertension, or malignancies) requiring pharmacological treatment
* Current or previous mindfulness meditation practice within the 12 months prior to study enrollment

Where it's running

• IRCCS Centro San Giovanni di Dio Fatebenefratelli
  Brescia, Italy Recruiting

Study contacts

• Principal investigator: Mariangela Lanfredi, psychologist — IRCCS Centro San Giovanni di Dio Fatebenefratelli
• Study coordinator: Mariangela Lanfredi
• Email: mlanfredi@fatebenefratelli.eu
• Phone: 00390303501504

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Low-intensity focused ultrasound targeting the subthalamic nucleus for OCD

  A short test is being done to see if a wearable, non-invasive ultrasound device can safely and tolerably help adults with OCD by targeting a brain region called the subthalamic nucleus.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT07887633

• Targeted brain stimulation for OCD: test of tTIS on nucleus accumbens

  This study tests whether targeted temporal interference stimulation of the nucleus accumbens can help reduce obsessive-compulsive symptoms in adults with OCD, compared with sham stimulation.

  Recruiting Beijing HuiLongGuan Hospital · Hefei, Anhui · NCT07805200

• Anxiety Skills Study: See if video skill training plus therapy helps people with anxiety

  This study tests whether a brief video-based skill training can help people with anxiety as well as four therapy sessions, and how durable the effects are over a year.

  Recruiting Ohio State University · Columbus, Ohio · NCT07774481

• AttunE LIFU for OCD: a non-invasive brain stimulation study

  This trial tests ATTN201, a wearable ultrasound headband, to see if it helps adults with OCD compared to a sham treatment.

  Recruiting Phase 2 University of Pennsylvania · San Francisco, California · NCT07728994

• Combined ERP and Habit Reversal Therapy for Tourettic OCD

  This study tests whether a merged Exposure and Response Prevention and Habit Reversal Therapy helps adults with Tourettic OCD more than either therapy alone or basic psychoeducation.

  Recruiting at 2 sites University College London Hospitals · London, London and 1 other locations · NCT07725926

• Safety and feasibility of a next-generation dome helmet for neuromodulation in OCD

  This study tests whether a new focused ultrasound helmet can safely help people with treatment-refractory OCD see if their symptoms improve.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07704632

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.