Targeted brain stimulation for OCD: test of tTIS on nucleus accumbens

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the therapeutic potential and possible brain-behavior mechanisms of nucleus accumbens–targeted transcranial temporal interference stimulation (tTIS) in OCD. Participants receive either active or sham tTIS for 5 consecutive days, with outcomes measured at baseline, after treatment, and during follow-up. Assessments include the Yale-Brown Obsessive Compulsive Scale, psychological questionnaires, behavioral tasks, resting-state EEG, and multimodal MRI to explore clinical effects and neural changes associated with the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Were between 18 and 65 years old;
* Were diagnosed with OCD by an experienced psychiatrist utilizing the Structured Clinical Interview for DSM-5 (SCID);
* Were able to participate in the entire trial and face-to-face on-site assessment

Exclusion Criteria:

* Pregnant or breastfeeding;
* Suffered from organic brain diseases or severe physical illness;
* Had a history of substance or alcohol abuse;
* Presence of comorbid psychiatric disorders (e.g., major depressive disorder) or a high risk of suicide;
* Have received electroconvulsive therapy, transcranial magnetic stimulation, tDCS, tACS, or other neurostimulation treatments within the past 6 months;
* Presence of contraindications to MRI or tTIS, such as severe head trauma, prior brain surgery, intracranial or cardiac metallic implants, etc.

Where it's running

• The Fourth People's Hospital of Anhui Province
  Hefei, Anhui, China Recruiting

Study contacts

• Study coordinator: Xiang-yang Zhang
• Email: zhangxy99@mail.tsinghua.edu.cn
• Phone: 18513299860

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.