Investigating brain and genetic changes in anxiety and OCD treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with obsessive-compulsive disorder (OCD), social anxiety disorder, and panic disorder undergoing the Bergen 4-Day Treatment (B4DT), an intensive exposure-based therapy. The study aims to assess psychological and neurobiological changes associated with treatment response by measuring symptom severity and collecting saliva samples for DNA methylation analysis. Additionally, a subset of participants will undergo multimodal MRI to explore brain changes over time. The research will involve 500 OCD patients and a smaller group of patients with other anxiety disorders, alongside healthy controls for comparison.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with obsessive-compulsive disorder, panic disorder or social anxiety disorder using DSM-5 criteria
* Referred to National Clinic for 4-Day Treatment, Haukeland University Hospital, Bergen, Norway
* Consented to participate in the "Kvalitetsregister for konsentrerte behandlingsformat"

Exclusion Criteria:

* Suicidal, ongoing mania, primary eating disorder, intellectual disability, ongoing psychosis, ongoing substance abuse

For MRI substudy:

Inclusion Criteria:

\- For the healthy controls, no previous or current psychiatric disorders as detected by the Mini International Neuropsychiatric Interview (MINI)

Exclusion Criteria:

\- MRI incompatibility (e.g. pregnancy, metal implants)

Where it's running

• Bergen Center for Brain Plasticity
  Bergen, Vestland, Norway Recruiting

Study contacts

• Principal investigator: Bjarne Hansen, PhD — Haukeland University Hospital
• Study coordinator: Bjarne Hansen, PhD
• Email: bjarne.kristian.aaslie.hansen@helse-bergen.no
• Phone: +4792090765

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.