Understanding why OCD therapy fails
Cognitive and Neural Networks in Psychiatry (CNNP): Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure (ERP in Silico)
University College, London · NCT05520398
This study is trying to understand why therapy sometimes doesn't work for people with OCD by looking at their brain activity and behavior before and after treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | University College, London (other) |
| Locations | 1 site (London) |
| Trial ID | NCT05520398 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the neural mechanisms that contribute to treatment failure in patients with obsessive-compulsive disorder (OCD). It will assess patients before and after undergoing cognitive behavioral therapy (CBT) with exposure and response prevention (ERP), focusing on symptom severity and decision-making processes. By evaluating changes in behavior and symptom alleviation, the study seeks to enhance therapy outcomes for OCD patients. A total of 90 participants will be recruited at University College London's Wellcome Centre for Human Neuroimaging.
Who should consider this trial
Good fit: Ideal candidates are individuals diagnosed with obsessive-compulsive disorder who are fluent in English and are about to start therapy.
Not a fit: Patients with co-occurring conditions such as autism spectrum disorder, psychosis, or severe learning disabilities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved therapeutic strategies for patients with OCD, enhancing their treatment outcomes.
How similar studies have performed: While this study explores a specific aspect of OCD treatment, similar studies have shown promise in understanding therapy outcomes, making this approach both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of obsessive-compulsive disorder (OCD) * Fluent in written and spoken English * Normal/corrected to normal vision * Expecting to start OCD therapy Exclusion Criteria: * Autism spectrum disorder, psychosis, schizophrenia, addiction, substance abuse, bipolar, hoarding, or Tourette disorder * Hearing conditions: tinnitus, ear inflammation, hearing sensitivity, hearing loss, requires hearing aids * Colour blindness * Severe learning disabilities
Where this trial is running
London
- Max Planck UCL Centre for Computational Psychiatry and Ageing Research — London, United Kingdom (RECRUITING)
Study contacts
- Principal investigator: Tobias Hauser, PhD — University College, London
- Study coordinator: Tricia Seow, PhD
- Email: t.seow@ucl.ac.uk
- Phone: +44-(0)203-1087538
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obsessive-Compulsive Disorder