Understanding why OCD therapy fails

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the neural mechanisms that contribute to treatment failure in patients with obsessive-compulsive disorder (OCD). It will assess patients before and after undergoing cognitive behavioral therapy (CBT) with exposure and response prevention (ERP), focusing on symptom severity and decision-making processes. By evaluating changes in behavior and symptom alleviation, the study seeks to enhance therapy outcomes for OCD patients. A total of 90 participants will be recruited at University College London's Wellcome Centre for Human Neuroimaging.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of obsessive-compulsive disorder (OCD)
* Fluent in written and spoken English
* Normal/corrected to normal vision
* Expecting to start OCD therapy

Exclusion Criteria:

* Autism spectrum disorder, psychosis, schizophrenia, addiction, substance abuse, bipolar, hoarding, or Tourette disorder
* Hearing conditions: tinnitus, ear inflammation, hearing sensitivity, hearing loss, requires hearing aids
* Colour blindness
* Severe learning disabilities

Where it's running

• Max Planck UCL Centre for Computational Psychiatry and Ageing Research
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Tobias Hauser, PhD — University College, London
• Study coordinator: Tricia Seow, PhD
• Email: t.seow@ucl.ac.uk
• Phone: +44-(0)203-1087538

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Low-intensity focused ultrasound targeting the subthalamic nucleus for OCD

  A short test is being done to see if a wearable, non-invasive ultrasound device can safely and tolerably help adults with OCD by targeting a brain region called the subthalamic nucleus.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT07887633

• Mindfulness-Based Cognitive Therapy for OCD Delivered Online

  This study tests a synchronous online MBCT program for adults with OCD to see if it is acceptable and feasible and to explore links between biological markers, OCD severity, and treatment response.

  Recruiting IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia · NCT07834567

• Targeted brain stimulation for OCD: test of tTIS on nucleus accumbens

  This study tests whether targeted temporal interference stimulation of the nucleus accumbens can help reduce obsessive-compulsive symptoms in adults with OCD, compared with sham stimulation.

  Recruiting Beijing HuiLongGuan Hospital · Hefei, Anhui · NCT07805200

• Anxiety Skills Study: See if video skill training plus therapy helps people with anxiety

  This study tests whether a brief video-based skill training can help people with anxiety as well as four therapy sessions, and how durable the effects are over a year.

  Recruiting Ohio State University · Columbus, Ohio · NCT07774481

• AttunE LIFU for OCD: a non-invasive brain stimulation study

  This trial tests ATTN201, a wearable ultrasound headband, to see if it helps adults with OCD compared to a sham treatment.

  Recruiting Phase 2 University of Pennsylvania · San Francisco, California · NCT07728994

• Combined ERP and Habit Reversal Therapy for Tourettic OCD

  This study tests whether a merged Exposure and Response Prevention and Habit Reversal Therapy helps adults with Tourettic OCD more than either therapy alone or basic psychoeducation.

  Recruiting at 2 sites University College London Hospitals · London, London and 1 other locations · NCT07725926

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.