Condition

Mood Disorders clinical trials and research

• 29Clinical trials
• 16NIH research projects
• 13Countries

Newest Mood Disorders clinical trials

All recruiting trials (29)

• Videoconference Brief Cognitive Behavioral Therapy for mood disorders at high suicide risk

  This study tests a short online CBT program to help people with mood disorders who are at high risk of suicide, and compares inflammatory biomarkers between groups.

  Recruiting Asan Medical Center · Seoul · NCT07857291

• Digital Mental Health support for Asian Americans

  We’re testing online digital tools to help Asian American adults cope with sociocultural stressors, by training clinicians and seeing if outcomes improve for clients.

  Recruiting University of California, Berkeley · Brooklyn, New York · NCT07771322

• Suicide risk and learned suicide ability in people with mood disorders

  This project will try to identify which biological, psychological, social, and clinical factors relate to suicide risk and the learned ability for suicide in people aged 16–60 with mood disorders by collecting blood, urine, and questionnaire data.

  Recruiting Tianjin Anding Hospital · Tianjin, Tianjin Municipality · NCT07523490

• Long-term psychotropic medication effects on eye movements measured with the Gaize VR headset

  This project will test whether the Gaize VR headset can detect eye-movement patterns associated with long-term use of prescribed psychotropic medications in adults.

  Recruiting Gaize · Philadelphia, Pennsylvania · NCT07389473

• Imagery rescripting at your GP practice

  This study will see if five sessions of imagery rescripting delivered by trained mental health assistants at a GP practice can reduce depressive symptoms in adults with depression or low self-esteem.

  Recruiting University of Amsterdam · Amsterdam, North Holland · NCT07362511

• Integrated care for older adults with major depression and multiple chronic conditions

  This program will test whether a coordinated, person-centered care approach called I-CONNECT helps older adults (65+) with depression or bipolar disorder and at least two long-term physical illnesses feel better and manage their care more easily.

  Recruiting KU Leuven · Leuven · NCT07211750

• Youth suicide risk factors and personalized reduction strategies in young adults

  This study tests whether combining clinical data, genetic information, neuroimaging, and microbiome data can help identify risk factors and see if a dTMS-based intervention reduces suicide risk in young adults with mood disorders.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT07188506

• Teleo virtual therapy for kids: testing engagement and outcomes in clinical care

  We’re testing whether Teleo, a kid-focused virtual therapy platform, keeps young patients more engaged and improves anxiety and mood symptoms compared with standard video calls.

  Recruiting Stanford University · Monterey, California and 1 other locations · NCT07155707

• Unified Protocol for emotional disorders in prison groups

  This study tests the Unified Protocol in group sessions to help inmates with anxiety, depression, and related mood issues.

  Recruiting Instituto de Investigación Sanitaria Aragón · Manresa, Catalonia and 1 other locations · NCT07070531

• Neuro-computational look at mood fluctuations in depression and bipolar disorder.

  This tests whether combining brain scans, cognitive tests, and daily smartphone mood tracking can model and help predict mood changes in people with depression or bipolar disorder.

  Recruiting at 2 sites Centre Hospitalier St Anne · Paris, Paris and 1 other locations · NCT07033923

• Preventive behavioral intervention for young adults with psychotic experiences

  This study is testing if a new Resilience Training program can help college freshmen and sophomores who are at risk for serious mental illnesses feel better and prevent issues like psychosis, mood swings, and anxiety.

  Recruiting Massachusetts General Hospital · Charlestown, Massachusetts · NCT06929442

• Accelerated versus once-daily theta-burst stimulation for late-life depression

  This test compares multiple theta-burst brain stimulation sessions per day to one session per day to see which better reduces symptoms in people 60 and older with moderate to severe treatment-resistant depression.

  Recruiting at 2 sites Centre for Addiction and Mental Health · Toronto, Ontario and 1 other locations · NCT06854367

• Understanding sensory profiles of patients using a calming room

  This study looks at how patients in a psychiatric hospital respond to different senses before and after using a calming room to see if their sensory experiences affect their mental health.

  Recruiting Centre Hospitalier Esquirol · Limoges, New Aquitaine · NCT06839950

• Cognitive Behavioural Therapy for youth with mood and anxiety disorders

  This study is testing a new type of Cognitive Behavioural Therapy called CBT-MyOWL for young people aged 14-19 with mood and anxiety disorders to see if it helps them stick with treatment and feel better compared to standard therapy.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT06532500

• Testing a new drug for treatment-resistant depression

  This study is testing a new drug called HNK to see if it can help people with treatment-resistant depression feel better when other medications haven't worked.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06511908

• Investigating the effects of citalopram on brain response to emotions

  This study tests how the antidepressant citalopram affects the brain's response to emotions in healthy people by comparing brain scans after taking the medication or a placebo.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT06412315

• A platform for collecting data on mood disorders

  This study is trying to create a better way to collect information from people with mood disorders like depression and bipolar disorder to help find new treatments that work for them.

  Recruiting at 9 sites St. Joseph's Healthcare Hamilton · Calgary, Alberta and 8 other locations · NCT06408012

• Exploring new brain stimulation targets for mental health conditions

  This study is testing how a brain stimulation treatment can help people with depression, anxiety, OCD, and schizophrenia by looking at changes in their brain and behavior.

  Recruiting Phase 2 Brigham and Women's Hospital · Sunnyvale, California and 1 other locations · NCT06376734

• Heat and cold therapy for reducing depression symptoms

  This study is testing whether a combination of heat therapy and a cold water plunge can help reduce depression symptoms in adults with major depressive disorder.

  Recruiting Vail Health Behavioral Health · Edwards, Colorado · NCT06263738

• Combining neurostimulation with emotion regulation training for emotional issues

  This study is testing if combining brain stimulation with training on how to manage emotions can help people with emotional issues feel better.

  Recruiting Duke University · Durham, North Carolina · NCT05712057

• Using RxWell to Reduce Opioid Use After Knee or Hip Surgery

  This study is testing whether a digital tool called RxWell can help people with mood disorders who are having knee or hip surgery reduce their opioid use and improve their mental health after the operation.

  Recruiting at 3 sites University of Pittsburgh · Monroeville, Pennsylvania and 2 other locations · NCT05658796

• Evaluating personalized medication based on genetic testing for psychiatric disorders

  This study is testing if giving personalized medication advice based on your genes can help people with mood, anxiety, or psychotic disorders feel better compared to regular medication dosing.

  Recruiting at 8 sites Parnassia Groep · Syracuse, New York and 8 other locations · NCT05656469

• Understanding children's emotions in therapy

  This study is testing a new therapy approach for kids aged 8 to 15 with anxiety, depression, trauma, or behavior issues to see if it helps them feel better compared to those who aren't receiving treatment right away.

  Recruiting at 2 sites University of Guelph · Guelph, Ontario and 1 other locations · NCT05637320

• Comparing Lemborexant, Zopiclone, and Clonidine for treating insomnia in chronic pain patients

  This study is testing whether Lemborexant, Zopiclone, or Clonidine can help people with chronic pain sleep better and manage their pain.

  Recruiting Salem Anaesthesia Pain Clinic · Surrey, British Columbia · NCT05618002

• Cognitive-behavioral therapy and exercise training for teenage girls at risk for type 2 diabetes

  This study is testing if cognitive-behavioral therapy, exercise training, or both can help teenage girls at risk for type 2 diabetes improve their health and reduce stress and depression.

  Recruiting at 2 sites Colorado State University · Aurora, Colorado and 1 other locations · NCT05543083

• Mood changes during TNF-alpha blocker treatment for chronic inflammatory rheumatic diseases

  This will test whether starting TNF-alpha blocker treatment improves anxiety or depression symptoms in adults with rheumatoid arthritis, spondyloarthritis, ankylosing spondylitis, or psoriatic arthritis.

  Recruiting Centre Hospitalier Universitaire de Besancon · Besançon · NCT04817072

• Evaluating a new treatment for adolescent depression

  This study is testing a new therapy for teenagers with a history of depression to see if it can help prevent them from feeling depressed again.

  Recruiting at 3 sites Ohio State University · Columbus, Ohio and 2 other locations · NCT03859297

• Developing MRI techniques to study mood and anxiety disorders

  This study is testing new MRI techniques to see how the brains of people with mood and anxiety disorders work compared to healthy individuals.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00397111

• Evaluation of patients with mood and anxiety disorders and healthy volunteers

  This study is looking for people with mood and anxiety disorders, as well as healthy volunteers, to see if they can help with research that aims to better understand these conditions.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00024635

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding gene activity in the brains of people with mood disorders who died by suicide

  A study to map which genes are active in brain cells and where they are in the brains of people with mood disorders who attempted or died by suicide, using advanced single-cell and spatial techniques.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11349216

• Synaptic changes in mood disorders and suicide risk

  This project studies brain Synapse signals in people with mood disorders, including those with a recent suicide attempt, to understand what changes are linked to suicide risk and how ketamine might work.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11349215

• Integrating immune and brain reward biology in veterans with mood problems

  A study in veterans with mood disorders looks at how the immune system and brain reward circuits may work together to drive depression and suicide risk.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11320777

• Mindfulness to reduce mood swings in teens at risk for mood disorders

  This project teaches mindfulness skills to teens and young adults with family histories of mood disorders to help reduce frequent mood swings and improve sustained attention.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11285153

• Understanding how calcium channels affect substance use and mood disorders

  This study is looking at how problems with drugs and mood can affect each other, especially when someone is trying to stay off drugs, and it’s testing how certain brain channels might help us find better treatments for people dealing with both issues.

  NIH research Yale University · New Haven, United States · NIH-11144027

• Exploring the link between immune system issues and mood disorders in veterans

  This study is looking at how problems with the immune system might affect mood and increase the risk of suicide in veterans, using blood tests and brain scans to find clues that could help improve diagnosis and treatment for those dealing with depression.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11052103

• Understanding how mindfulness can help youth at risk for mood disorders

  This study is looking at how mindfulness practices can help young people who are at risk for mood disorders by improving their emotional control and mood, and it aims to find out who might benefit the most from these techniques.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11035159

• Identifying brain markers for mood disorders in at-risk youth

  This study is looking at how the brains of young people with a family history of mood disorders, like depression and bipolar disorder, are different, so we can find signs that might help us predict who could develop these conditions in the future and help them get the right support early on.

  NIH research Yale University · New Haven, United States · NIH-11007275

• How aging affects emotion regulation in mood disorders

  This study is looking at how getting older affects the way people with mood disorders, like bipolar disorder and depression, manage their emotions, and it hopes to find ways to improve emotional health for older adults.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10974481

• Understanding how calcium channels affect substance use and mood disorders

  This study is looking at how problems with drugs and mood, like anxiety and depression, are connected in the brain, especially when someone is trying to stay off drugs, and it hopes to find new ways to help people who struggle with both issues.

  NIH research Yale University · New Haven, United States · NIH-10887588

• Using data to understand different symptoms in mood disorders for better treatment options

  This study is looking to make mood disorder treatments better by figuring out how different symptoms respond to various therapies, especially for people getting electroconvulsive therapy (ECT), so that doctors can personalize treatments based on what works best for each person.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10832541

• Improving emotion regulation in bipolar mood disorders

  This study is exploring new ways to help people with bipolar disorder manage their emotions better by using special brain imaging and stimulation techniques, with the goal of creating personalized treatments that work more effectively than what’s currently available.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10827395

• Using a mobile app to enhance therapy for teens at risk of severe mood disorders

  This study is looking to make therapy better for teens aged 12 to 20 who are at risk for serious mood issues, like depression and bipolar disorder, by using a helpful mobile app that reminds them to practice what they learn in therapy and track how they’re feeling.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10817156

• How endocannabinoids affect stress and mood disorders

  This study looks at how a part of the brain helps manage stress and mood by using natural chemicals called endocannabinoids, and it aims to find new ways to help people who struggle with anxiety and mood disorders.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-10689093

• Understanding how reward processing differs in genetic frontotemporal dementia and mood disorders

  This study is looking at how people with genetic frontotemporal dementia and mood disorders experience rewards differently, so we can better understand these conditions and help improve how they are diagnosed.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10543554

• How stress affects thinking in people with mood disorders

  This study is looking at how stress and anxiety affect thinking and decision-making in people with mood disorders like depression, to help find better treatments for those who struggle more under stress.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10430138

Related topics

Quick answers

How many Mood Disorders clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (14 trials), Canada (5 trials), France (3 trials), Netherlands (2 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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