Imagery rescripting treatment for OCD and BDD
Official title: Imagery Rescripting for Obsessive Compulsive Disorder and Body Dysmorphic Disorder: a Multiple-Baseline Single-Case Experimental Design.
Run by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · NCT06346301 · Data updated 2026-11-12
This study is testing a new therapy called imagery rescripting to see if it can help people with Obsessive Compulsive Disorder and Body Dysmorphic Disorder feel better and change their negative thoughts.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 36 (estimated) |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam-Zuidoost, North Holland) |
| Status | Recruiting |
| Started | April 21, 2023 |
| Main results expected | January 2026 |
| Study ends | January 2027 |
| Registry record updated | April 4, 2024 |
| Trial ID | NCT06346301 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who meet the DSM-5 criteria for OCD or BDD and have stable medication for at least six weeks.
✕Probably not a fit
Patients with current severe mental health issues such as active psychosis or suicidal plans may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of imagery rescripting (ImRs) as a treatment for Obsessive Compulsive Disorder (OCD) and Body Dysmorphic Disorder (BDD) through a multiple baseline case series design. Eighteen participants with OCD and eighteen with BDD will undergo a variable baseline period followed by a series of treatment sessions. The primary focus is on changes in core beliefs and symptoms, measured through various scales and qualitative interviews. The study aims to assess both immediate and longer-term effects of the intervention on patients' mental health.
Why it matters
Potential benefit: If successful, this treatment could significantly reduce symptoms of OCD and BDD, improving patients' quality of life.
How similar studies have gone: While the approach of imagery rescripting is gaining interest, this specific application for OCD and BDD is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Meet the criteria for OCD or BDD, a primary diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) * Are aged 18 and beyond * Dutch literacy * Cut-off Y-BOCS of 20 * No change in medication. Stable dose at least 6 weeks prior to study. Exclusion Criteria: * Current (hypo)mania * Active suicidal plans * Current psychosis (excluding delusional symptoms related to disorder) * Alcohol or drugs abuse as diagnosed by Diagnostic and Statistical Manual of Mental Disorders (DSM-5) * Electroconvulsive therapy in last 6 months * Neurological disorder or Intelligence Quotient \< 80
Where it's running
-
Department of Psychiatry, AMC
Amsterdam-Zuidoost, North Holland, Netherlands Recruiting
Study contacts
- Principal investigator: Damiaan Denys, Prof. — Amsterdam UMC
- Study coordinator: Tibor van Verseveld
- Email: t.r.vanverseveld@amsterdamumc.nl
- Phone: +31619624228
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Digital stepped-care mindfulness program for emotional disorders
This project tests whether adding an online mindfulness program to usual care helps adults (18–65) with depression, anxiety, OCD, or PTSD recover faster and stay well longer.
-
Combining neurostimulation with emotion regulation training for emotional issues
This study is testing if combining brain stimulation with training on how to manage emotions can help people with emotional issues feel better.
-
Testing dextromethorphan for treating OCD and related disorders
This study is testing if adding a common cough medicine called dextromethorphan to the usual OCD treatment can help people with OCD and similar disorders feel better.
-
Identifying genetic factors in children affected by antidepressant side effects
This study is trying to find out if certain genes can help predict which children might have negative side effects from antidepressants, so doctors can better manage their treatment.
-
Using caloric vestibular stimulation to improve insight in obsessive-compulsive disorders
This study is testing whether a special type of brain stimulation can help people with obsessive-compulsive disorders better understand their thoughts and behaviors to improve their treatment outcomes.
-
Understanding anxiety, depression, and bipolar disorder over time in China
This study tests how anxiety, depressive, and bipolar symptoms change over three years to find patterns that help with earlier recognition and prediction in people aged 12–55.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.