Condition

Neuropathic Pain clinical trials and research

• 68Clinical trials
• 108NIH research projects
• 20Countries

Newest Neuropathic Pain clinical trials

All recruiting trials (68)

• Neuropathic Pain Severity in Lumbar Spinal Stenosis and Its Link to Radiology

  This study will test how severe neuropathic pain is in adults with lumbar spinal stenosis and see if it relates to MRI findings and other clinical features.

  Recruiting Marmara University · Istanbul, Istanbul · NCT07855445

• Virtual Reality-Based Hypnotherapy to Help Pain, Sleep, and Mood in Spinal Cord Injury

  Adults with spinal cord injury will try adding short VR-based hypnotherapy sessions to their standard physiotherapy to see if it reduces pain and improves sleep and mood.

  Recruiting Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Istanbul, Istanbul · NCT07846410

• Extended-release Pregabalin for nerve pain from diabetes or shingles

  This phase 3 study tests an extended-release form of pregabalin to see if it reduces nerve-pain symptoms in adults with diabetic neuropathy or postherpetic neuralgia.

  Recruiting at 15 sites Phase 3 Brainfarma Industria Química e Farmacêutica S/A · Salvador, Estado de Bahia and 14 other locations · NCT07712913

• High-Intensity Peripheral Magnetic Stimulation for Traumatic Nerve Injury

  This study tests whether adding high-intensity peripheral magnetic stimulation to a structured exercise program can reduce pain and improve function for adults with a traumatic peripheral nerve injury.

  Recruiting Gaziler Physical Medicine and Rehabilitation Education and Research Hospital · Ankara · NCT07705490

• Hematological clues and how patients respond to nerve blocks for neuropathic pain

  This study looks at blood inflammation markers to see if they relate to how well people with neuropathic pain respond to sympathetic nerve blocks.

  Recruiting Ankara City Hospital Bilkent · Ankara, Cankaya · NCT07596823

• Cord plasma eye drops to treat neuropathic corneal pain

  This trial will test whether cord plasma eye drops can reduce long-lasting nerve-related corneal pain in people with evidence of corneal nerve damage.

  Recruiting Singapore Eye Research Institute · Singapore, Singapore · NCT07566806

• Comparing different NSAIDs plus home exercises for frozen shoulder

  This will test whether taking one of several NSAIDs (diclofenac, meloxicam, or indomethacin) together with home shoulder exercises helps adults aged 18–75 with frozen shoulder and whether pain type changes the benefit.

  Recruiting Konya Beyhekim Training and Research Hospital · Konya, Selçuklu · NCT07493226

• Ultrasound-guided shoulder injections for frozen shoulder

  This tests whether adding ultrasound-guided suprascapular nerve block, with or without a subacromial injection, to a home exercise program reduces pain and improves shoulder function in adults with chronic frozen shoulder.

  Recruiting Konya Beyhekim Training and Research Hospital · Konya, Selçuklu · NCT07493213

• Ultrasound-guided SPS block versus surgeon intercostal block to prevent chronic pain after thoracoscopic (VATS) surgery

  This trial will test whether an ultrasound-guided Serratus Posterior Superior (SPS) block given before elective VATS reduces chronic post-thoracotomy pain compared with a surgeon-administered intercostal block.

  Recruiting Medipol University · Istanbul, Bagcilar · NCT07436806

• Regenerative Peripheral Nerve Interface (RPNI) for painful neuromas after lower-limb amputation

  This project tests whether RPNI surgery reduces mechanical sensitivity and neuropathic pain and improves prosthesis comfort in adults with symptomatic neuromas after major lower-limb amputation.

  Recruiting Saglik Bilimleri Universitesi · Ankara, Ankara · NCT07420192

• Spinal cord stimulation plus rehabilitation for severe chronic neuropathic leg pain

  This project will try combining spinal cord stimulation with a multidisciplinary rehabilitation program to reduce severe nerve pain and improve physical function in adults with chronic neuropathic leg pain.

  Recruiting Oslo University Hospital · Oslo · NCT07403331

• Neuropathic pain after childhood amputation

  This project sees how common phantom and residual limb neuropathic pain is and how it affects children and teens who had limb amputations.

  Recruiting Hopitaux de Saint-Maurice · Saint-Maurice · NCT07401966

• Erector spinae plane block versus transcutaneous radiofrequency for postherpetic neuralgia

  This project will see if erector spinae plane block or transcutaneous radiofrequency works better to reduce pain in adults with postherpetic neuralgia.

  Recruiting Diskapi Teaching and Research Hospital · Ankara · NCT07400640

• Managing acute chest pain after combat-related thoracic injuries in Ukraine

  This study will test whether cryoablation or radiofrequency ablation better controls severe chest pain and speeds recovery in adults with combat-related chest injuries treated at Ukrainian hospitals.

  Recruiting Lviv National Medical University · Rivne · NCT07380789

• Safety and how ASCT-83 behaves in healthy adults

  Researchers are testing whether ASCT-83 is safe and how it behaves in the body compared with a placebo in healthy adults.

  Recruiting Phase 1 Alcamena Stem Cell Therapeutics · Saint Paul, Minnesota · NCT07363395

• Relationship between high PainDETECT scores, pain location, and diagnosis in musculoskeletal care

  See if PainDETECT questionnaire scores relate to pain locations and clinical diagnoses in adults with musculoskeletal pain who visit a sports medicine clinic.

  Recruiting Uskudar University · Istanbul · NCT07356115

• PEA and Scutellaria combined with exercise for chemotherapy-related nerve pain

  This trial will see if taking PEA and Scutellaria together with therapeutic exercise helps adults who have nerve pain after chemotherapy.

  Recruiting University of Palermo · Palermo, Italia · NCT07352514

• Progressive resistance exercise to reduce pain in people with multiple sclerosis

  This program will test whether 12 weeks of progressive resistance exercise can reduce chronic neuropathic pain in adults with multiple sclerosis.

  Recruiting University of Aarhus · Aarhus, Denmark · NCT07342777

• Closed-loop spinal cord stimulation for painful chemotherapy-induced peripheral neuropathy

  This observational project will try closed-loop spinal cord stimulation to reduce neuropathic pain in adults who developed peripheral neuropathy after chemotherapy.

  Recruiting at 5 sites Rijnstate Hospital · Arnhem and 4 other locations · NCT07304401

• Repetitive TMS to relieve neuropathic pain after spinal cord injury

  This trial will test whether rTMS aimed at the anterior cingulate cortex reduces chronic neuropathic pain in adults with spinal cord injury compared with motor cortex stimulation or a sham treatment.

  Recruiting at 2 sites Ankara Etlik City Hospital · Ankara, Yenimahalle and 1 other locations · NCT07293780

• Home-use brain stimulation (tDCS) for chronic neuropathic or nociplastic pain

  This trial will test whether using a home tDCS device for 12 weeks can reduce pain in people with chronic neuropathic or nociplastic pain who had only short-term relief from rTMS.

  Recruiting Hospital Ambroise Paré Paris · Boulogne-Billancourt, Hauts de Seine · NCT07211256

• Thai PainPREDICT for detecting neuropathic pain in people with diabetes

  This project will test a Thai-language PainPREDICT questionnaire and a companion mobile app to help identify neuropathic pain in adults with type 1 or type 2 diabetes.

  Recruiting Chulalongkorn University · Pathum Wan, Bangkok · NCT07195045

• Immune and signaling markers in blood and spinal fluid during spinal cord stimulation for neuropathic pain

  This project tests whether measuring immune and signaling molecules in blood and cerebrospinal fluid can help explain and predict how spinal cord stimulation works for adults with chronic neuropathic pain.

  Recruiting Jan Biziel University Hospital No 2 in Bydgoszcz · Bydgoszcz · NCT07153211

• Neuropathic features in subacromial shoulder pain

  This project will test whether adults with subacromial shoulder pain lasting at least three months have neuropathic pain features and signs of central sensitization.

  Recruiting Izmir City Hospital · Izmir, İzmir · NCT07057128

• Refining multiple AI strategies for automatic pain assessment (RUGGI)

  This project tests whether AI models using wearable sensors, facial video/thermography, and physiological signals can detect and estimate pain in adults with chronic or cancer-related pain.

  Recruiting Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona · Salerno, Italy · NCT07038434

• Tulavi Allay nerve cap to prevent neuroma pain after finger or toe amputation

  Tests whether placing a Tulavi Allay nerve cap on a cut digital nerve at the time of traumatic amputation reduces neuroma-related pain in adults.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT06915662

• Using a new pathway to manage unexplained pain in children with severe neurological impairments

  This study is testing a new way for doctors to help manage unexplained pain in children with severe neurological impairments who can't tell us how they feel.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT06869928

• Ginger extract for sciatica

  This trial will test whether taking 2000 mg of ginger daily for 8 weeks helps adults with chronic sciatica reduce pain and change gut-related markers.

  Recruiting Phase 2 Texas Tech University Health Sciences Center · Lubbock, Texas and 1 other locations · NCT06817018

• Assessing nerve activation in spinal cord stimulation for chronic pain

  This study looks at how different settings on a spinal cord stimulator affect nerve activity and sensations in patients with chronic pain to help improve pain management.

  Recruiting AZ Delta · Roeselare · NCT06775535

• Crisugabalin for treating neuropathic pain after radiotherapy in head and neck cancer patients

  This study is testing if Crisugabalin can help reduce nerve pain after radiation treatment in people with head and neck cancer better than Pregabalin.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Fuzhou, Fujian and 10 other locations · NCT06766916

• Using Transcranial Magnetic Stimulation to Treat Neuropathic Pain from Spinal Cord Injuries

  This study is testing if a non-invasive brain treatment called rTMS can help reduce neuropathic pain and improve quality of life for people with spinal cord injuries.

  Recruiting Afyonkarahisar Health Sciences University · Afyonkarahisar · NCT06726954

• Evaluating outcomes in neurosurgery using standardized measures

  This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.

  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• Who is at risk for neuropathic pain during cancer care.

  We will try to use repeated cognitive-emotional and pain assessments to see who among adults with breast, gynecologic, colorectal, or lung cancer is likely to develop neuropathic pain during or after treatment.

  Recruiting at 18 sites University Hospital, Clermont-Ferrand · Ajaccio and 18 other locations · NCT06511674

• Using capsaicin patches to treat painful hand osteoarthritis

  This study is testing if a stronger capsaicin patch can help people with painful hand osteoarthritis feel less pain compared to a weaker version.

  Recruiting at 4 sites Phase 4 University Hospital, Clermont-Ferrand · Clermont-Ferrand and 3 other locations · NCT06444919

• New treatment for neuropathic pain in spinal cord injury patients

  This study is testing a new oral medication called EC5026 to see if it can safely help people with spinal cord injuries manage their nerve pain.

  Recruiting Phase 1 EicOsis Human Health Inc. · Augusta, Georgia · NCT06438471

• Understanding neuropathic pain after ankle fractures

  This study looks at how common nerve pain is after ankle fractures in adults aged 18-85 to better understand why some people still hurt after their bones heal.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06420141

• Outpatient ketamine infusion for chronic pain and PTSD in military personnel

  This study is testing if ketamine infusions can help military personnel with chronic pain and PTSD feel better compared to those who only receive magnesium.

  Recruiting Phase 4 Brooke Army Medical Center · San Antonio, Texas · NCT06414356

• Virtual-reality self-hypnosis for HIV-related chronic pain

  This trial will try a virtual-reality self-hypnosis program to see if it reduces chronic pain in adults living with HIV.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT06398847

• Virtual reality walking game for neuropathic pain relief in spinal cord injury patients

  This study tests if a virtual reality walking game can help adults with spinal cord injuries and ongoing nerve pain feel better.

  Recruiting Texas A&M University · College Station, Texas · NCT06330181

• Using deep rTMS to treat neuropathic pain and fibromyalgia

  This study is testing if a special type of brain stimulation can help people with neuropathic pain or fibromyalgia feel less pain over three months.

  Recruiting Hospital Ambroise Paré Paris · Boulogne-Billancourt and 1 other locations · NCT06250491

• Using brain stimulation to treat neuropathic pain

  This study is testing whether a brain stimulation technique can help people with neuropathic pain feel better by looking at how it affects their brain activity.

  Recruiting National Taiwan University Hospital · Taipei · NCT06237075

• Understanding migraines and neuropathic pain in osteoarthritis patients

  This study looks at how often people with osteoarthritis experience migraines and nerve pain to better understand the connection between these conditions.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand, France · NCT06224959

• Location of motor cortex stimulation electrodes in chronic neuropathic pain

  This study tests how the placement of motor cortex stimulation electrodes relates to response in adults with chronic neuropathic pain who already have implanted stimulation and a postoperative scan.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice, Alpes Maritimes · NCT06216717

• Examining the effects of pregabalin on sleep and pain in neuropathic pain patients

  This study is testing how pregabalin affects sleep and pain in people with chronic neuropathic pain to see if it helps them feel better.

  Recruiting at 2 sites Helsinki University Central Hospital · Helsinki, HUS and 1 other locations · NCT06155916

• Neuromodulation for treating neuropathic pain and depression

  This study is testing if a special brain treatment can help people with both nerve pain and depression feel better when regular pain medications haven't worked.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT06129890

• Monitoring and understanding chronic pain using AI and telemonitoring

  This study is testing a new way to manage chronic pain by using wearable technology and AI to better understand patients' pain experiences and improve their treatment.

  Recruiting at 4 sites ETH Zurich · Pietra Ligure, Savona and 3 other locations · NCT06044584

• Evaluating the effectiveness of capsaicin patches for chronic coccyx pain

  This study is testing if an 8% capsaicin patch can help people with chronic tailbone pain feel better compared to a lower concentration patch.

  Recruiting at 6 sites Phase 3 Nantes University Hospital · Brest and 5 other locations · NCT06023706

• Using body illusions and brain stimulation to treat pain in spinal cord injury

  This study is testing if combining body illusions with a type of brain stimulation can help reduce pain and improve sensation in people with spinal cord injuries.

  Recruiting University of Miami · Miami, Florida · NCT06010251

• Capsaicin patch for treating chronic pain in children

  This study is testing if a special capsaicin patch can help relieve chronic pain in kids aged 12 to 17 who have pain after an injury or surgery.

  Recruiting at 10 sites Phase 3 University Hospital, Brest · Amiens and 9 other locations · NCT05997979

• Improving spinal cord stimulation for chronic pain relief

  This study is testing if a new type of spinal cord stimulation can help people with chronic pain feel better compared to the standard method.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05968664

• Examining brain changes in veterans with chronic pain using spinal cord stimulation

  This study is testing how spinal cord stimulation affects the brains of veterans with chronic pain to see if it helps them feel better.

  Recruiting VA Office of Research and Development · Cleveland, Ohio · NCT05811312

• Calcitonin treatment for neuropathic pain after spinal cord injury

  This study is testing if calcitonin can help reduce the pain that people experience after a spinal cord injury compared to a placebo.

  Recruiting Tanta University · Tanta, Gharbia Governorate · NCT05805683

• Using a smartphone app to track pain and mood changes

  This study is testing a smartphone app to track pain and mood changes in people with chronic pain and healthy individuals to see how these factors affect pain over time.

  Recruiting Brown University · Providence, Rhode Island · NCT05754190

• Using Transcranial Magnetic Stimulation to Treat Neuropathic Pain in Spinal Cord Injury Patients

  This study is testing whether a type of brain stimulation called rTMS can help reduce neuropathic pain in people with spinal cord injuries.

  Recruiting Afyonkarahisar Health Sciences University · Afyonkarahisar · NCT05645003

• Predicting and understanding pain six months after radiotherapy for head and neck cancer

  This project will see if people treated with radiotherapy for head and neck cancer who still have pain at six months are more likely to keep smoking or drinking, be depressed, feel very tired, or have worse overall quality of life.

  Recruiting University Hospital, Caen · Caen · NCT05505188

• Training leg reflexes to reduce neuropathic pain after spinal cord injury

  This study is testing whether training leg reflexes can help reduce neuropathic pain in people with spinal cord injuries.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05492188

• Neuromodulation of the insula to treat chronic neuropathic pain

  This study is testing if stimulating a specific part of the brain can help people with long-lasting nerve pain feel better.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05404581

• Testing cannabis derivatives for neuropathic pain in Veterans

  This study is testing whether cannabis products like THC and CBD can help reduce chronic nerve pain in Veterans who are not currently using cannabis.

  Recruiting at 4 sites Phase 2 VA Office of Research and Development · San Diego, California and 5 other locations · NCT05351801

• Using Burst Deep Brain Stimulation to Treat Neuropathic Pain

  This study is testing a new way of using brain stimulation to see if it can help people with chronic nerve pain feel better compared to the usual method.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT05204472

• Platelet-rich fibrin to reduce pain after lumbar disc surgery

  This phase 3 trial tests whether applying platelet-rich fibrin around the nerve roots during lumbar disc surgery can lessen ongoing neuropathic pain after the operation.

  Recruiting Phase 3 University Hospital, Strasbourg, France · Strasbourg, Bas-Rhin · NCT05196503

• Using virtual reality walking games to help with neuropathic pain in spinal cord injury patients

  This study is testing whether playing virtual reality walking games can help adults with spinal cord injuries and ongoing nerve pain feel better.

  Recruiting at 2 sites Texas A&M University · Birmingham, Alabama and 2 other locations · NCT05005026

• Combining rTMS with virtual reality mirror therapy for neuropathic pain relief

  This study is testing if combining a brain stimulation technique with virtual reality therapy can help people with nerve pain feel better.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Bron and 1 other locations · NCT04867187

• Peripheral nerve block for painful diabetic neuropathy

  This study is testing if a nerve block can help adults with painful diabetic neuropathy feel less pain without stopping their regular medications.

  Recruiting University of Aarhus · Aarhus N, Jutland · NCT04699734

• Assessing the effects of spinal cord stimulators on diabetic neuropathy

  This study is testing if spinal cord stimulators can help people with diabetes and painful nerve damage feel better and improve their overall health.

  Recruiting University of Chicago · Chicago, Illinois · NCT04687215

• Evaluating Praga formulation for treating neuropathic pain

  This study is testing a new treatment called Praga to see if it can help people with nerve pain, especially those with diabetic polyneuropathy, feel better compared to other medications or a placebo.

  Recruiting Phase 3 Ems · Campinas, São Paulo · NCT04666714

• Exploring genetic factors in neuropathic pain

  This study is trying to find out if certain genes are linked to neuropathic pain to help understand why some people experience this condition.

  Recruiting at 5 sites Oslo University Hospital · Bergen and 4 other locations · NCT03862365

• Exploring new spinal cord stimulation methods for chronic pain relief

  This study is testing new ways of using spinal cord stimulation to see if they can help people with chronic pain feel better compared to traditional methods.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT03852381

• Home-based cortical stimulation for chronic neuropathic pain relief

  This study is testing whether a home-based brain stimulation treatment can help people with chronic nerve pain who haven't found relief from regular medications.

  Recruiting Hospices Civils de Lyon · Bron · NCT02346396

NIH-funded research (newest 40 of 108)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Peripheral nerve stimulation for chronic neuropathic pain in a new mechanistic trial

  A study at Stanford tests whether a painless-sounding electrical nerve treatment helps people with long-standing neuropathic pain when added to standard care.

  NIH research Stanford University · Stanford, United States · NIH-11579998

• Keratinocytes and nerve pain in chemotherapy patients

  A study tests a new approach to reduce painful nerve damage from chemotherapy by targeting skin cells called keratinocytes.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11447051

• High-frequency brain stimulation for trigeminal neuropathic pain

  A large, multi-site trial tests a non-invasive brain stimulation method to relieve chronic facial nerve pain for adults who have not found relief from other treatments.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11435301

• Programmable lithium-delivery devices for pain relief without motor loss

  A new bioelectronic system uses a safe lithium source and AI-powered control to deliver targeted pain relief for neuropathic pain, aiming to spare motor function.

  NIH research University of Chicago · Chicago, United States · NIH-11429988

• Glial-nerve conversations in neuropathic pain and diabetes

  This grant looks at how supportive brain and nerve cells communicate with pain-sensing neurons to understand and reduce chronic nerve pain in people.

  NIH research Duke University · Durham, United States · NIH-11420907

• Parmodulins with Low Abuse Potential for Neuropathic Pain

  A new class of pain medicines called parmodulins is being studied to help people with nerve-pain pain without high abuse risk.

  NIH research Function Therapeutics, INC. · Milwaukee, United States · NIH-11415152

• Nonopioid peptide therapy to reset nerve pain biology

  A new, first‑in‑class peptide medicine (ASCT‑83) is being developed to target the biology of neuropathic pain in adults, with early human testing planned after successful preclinical work.

  NIH research Alcamena Stem Cell Therapeutics, LLC · Baltimore, UNITED STATES · NIH-11387927

• ACVR1 signaling in pain and bone formation linked to nerve cells

  A patient-friendly look at a study exploring how ACVR1-related signals in nerve cells may drive pain and abnormal bone growth after injury or surgery.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11378156

• Targeting α9α10 nicotinic receptors to treat neuropathic pain

  A research project is exploring a new drug target in nerves to help people with neuropathic pain who don’t get good relief from opioids or other non-opioid medicines.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11375425

• Targeting a molecular stress pathway to relieve diabetic nerve pain

  A researcher at UT Dallas is testing whether blocking a cellular stress pathway can reduce nerve pain caused by diabetes.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11374475

• Exploring how EphB2 and NMDA receptors drive pain after cervical spinal cord injury

  This project looks at a specific molecular interaction in the spinal cord that may contribute to chronic pain after neck-level spinal cord injuries, with the goal of finding new ways to help patients who have neuropathic pain.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11371153

• Sensory testing to guide neuropathic pain treatment

  This project uses sensory tests to find patterns that help pick better medicines for people with neuropathic pain.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11365628

• Uncovering how oxysterols drive nerve-pain signals

  A researcher is studying how certain fat-derived chemicals called oxysterols and glial cells in the spinal cord may cause chronic neuropathic pain, with the aim of finding non-opioid ways to relieve it.

  NIH research Saint Louis University · Saint Louis, United States · NIH-11349606

• Diet and pain in Veterans with spinal cord injury

  A study to see if better diet quality is linked to lower chronic neuropathic pain in veterans with spinal cord injury.

  NIH research Miami VA Health Care System · Miami, United States · NIH-11338233

• Human HCN1-Selective Nanobodies for Non-Opioid Pain Relief

  A new, non-opioid treatment approach uses human HCN1-selective nanobodies attached to a smart linker to make a powerful pain-relief medicine for neuropathic pain.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11329911

• Astrocytes and nerve-related chronic pain

  Researchers are looking at how astrocytes (support cells in the spinal cord and brain) drive neuropathic pain to help people living with chronic nerve pain.

  NIH research Salk Institute for Biological Studies · La Jolla, UNITED STATES · NIH-11321273

• Brain and spinal cord scans to identify causes of pain after spinal cord injury

  Using advanced brain and spinal cord imaging to find patterns that predict and explain long-term nerve pain in people with spinal cord injury.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11321136

• Cannabis-based options for diabetic nerve pain in Veterans

  This project tests whether cannabis-derived medicines (THC, CBD, or combinations) can help reduce painful diabetic nerve damage in Veterans aged 21 and older.

  NIH research VA Connecticut Healthcare System · West Haven, United States · NIH-11310852

• RGS4 and long-term nerve pain

  This project looks at how a protein called RGS4 affects long-lasting nerve pain to help identify new non-opioid treatment targets for people with chronic neuropathic pain.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11306646

• Non-opioid, non-addictive treatments for nerve (neuropathic) pain

  New non-opioid medicines designed to relieve nerve pain without causing addiction or psychoactive side effects.

  NIH research Northeastern University · Boston, United States · NIH-11304476

• How nerve injury changes gene activity to cause long-lasting nerve pain

  This work looks at how nerve damage changes gene control in people with long-lasting nerve pain to find better treatment targets.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11300235

• Blocking EphB1/2 to treat peripheral nerve (neuropathic) pain

  This work is developing new non-opioid drugs that target EphB1/2 signaling to reduce peripheral neuropathic pain for people with nerve injury or chronic nerve pain.

  NIH research Texas Tech University Health Scis Center · Lubbock, United States · NIH-11290725

• Neuroinflammation in carpal tunnel pain

  This project uses PET/MR scans with a special tracer to look for inflammation in the brain and spinal cord of adults with carpal tunnel syndrome compared with healthy volunteers.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11286773

• B cells' role in nerve pain after injury

  Researchers want to find out whether immune cells called B cells cause or keep nerve pain after a peripheral injury, which could point to new treatments for people with neuropathic pain.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11284098

• Safer non-opioid medicines for nerve pain from chemotherapy

  Testing new versions of the pain drug flupirtine to help people with chemotherapy-related nerve pain while lowering the risk of liver damage.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11267965

• New RNA-based drug approach for chronic neuropathic pain

  A new antisense RNA therapy targets a human nerve RNA to help people with chronic neuropathic pain without opioids.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11266275

• Blocking a spinal protein to ease long-term nerve-injury pain

  Researchers are trying a new small-molecule drug that stops a protein in spinal immune cells to lower chronic nerve pain after injury.

  NIH research Birmingham VA Medical Center · Birmingham, United States · NIH-11264871

• Targeting LRP1 to reduce nerve inflammation and neuropathic pain

  This work looks at whether focusing on a protein called LRP1 in nerve support cells can help people with chronic neuropathic pain after peripheral nerve injury.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-11264842

• Advanced spinal cord stimulation for treating chronic pain without opioids

  This study is testing a new spinal cord stimulation device called HD64, designed to help people with chronic nerve pain find better relief without relying on opioids, and it aims to improve how well the device works for managing pain.

  NIH research Micro-Leads, INC. · Somerville, UNITED STATES · NIH-11249777

• CBD-based formulation to relieve chemotherapy-induced nerve pain

  A cannabidiol-based treatment is being studied to help people with nerve pain caused by certain chemotherapy drugs.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11246150

• Gene therapy to relieve spinal cord injury-related neuropathic pain

  This project tests a one-time gene therapy (6SHG/EM1) to reduce long-lasting neuropathic pain after spinal cord injury using a pig model to help move toward human treatment.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11212754

• Breathing-controlled electrical stimulation device for neuropathic pain after spinal cord injury

  A new, non-drug device aims to reduce neuropathic pain in people with spinal cord injuries using breathing-guided electrical stimulation.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11204885

• Plant-based blockers of a microglial proton channel for nerve pain

  Looking for plant-derived compounds that block a microglial proton channel to help reduce neuropathic (nerve) pain in people.

  NIH research University of California-Irvine · Irvine, United States · NIH-11174442

• Exploring a new long noncoding RNA's role in nerve pain

  This study is looking at a special type of RNA that might affect how we feel pain after nerve injuries, and it's for anyone interested in understanding more about neuropathic pain and finding better ways to manage it.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11161371

• New ways to treat nerve pain from diabetes

  This project explores how a chemical byproduct called methylglyoxal contributes to nerve pain in people with diabetes, hoping to find better treatments.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11145851

• Understanding a specific receptor for neuropathic pain relief

  This project aims to find new, safer ways to treat chronic neuropathic pain by focusing on a specific target in the body.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11143249

• Understanding Nerve Signals in Pain and Abnormal Bone Growth

  This project explores how specific nerve signals contribute to long-lasting pain and abnormal bone formation, hoping to find new ways to help people with these conditions.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11143096

• Understanding Pain After Spinal Cord Injury

  This project looks at how certain brain signals contribute to long-lasting pain after a spinal cord injury, hoping to find new ways to help patients.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11143076

• Developing new treatments for nerve pain using AT2 inhibitors

  This study is exploring a new way to help people with nerve pain feel better by targeting a specific receptor in the body, which could lead to safer pain relief options that don't involve addictive medications like opioids.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11139279

• Developing Better Medicines for Epilepsy and Nerve Pain

  This research aims to create new medications that can help manage seizures in epilepsy and reduce nerve pain.

  NIH research Northwestern University · Chicago, UNITED STATES · NIH-11115834

Related topics

Quick answers

How many Neuropathic Pain clinical trials are recruiting right now?

68, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (17 trials), Turkey (Türkiye) (14 trials), France (14 trials), Italy (4 trials), Norway (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 5, Phase 2: 4, Phase 4: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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