Examining the effects of pregabalin on sleep and pain in neuropathic pain patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical study investigates the relationship between sleep quality and neuropathic pain in patients undergoing treatment with pregabalin. It involves 40 participants aged 18 to 75 with chronic moderate to severe pain due to peripheral neuropathy, who are divided into two groups based on their insomnia severity. The study assesses sleep through various methods, including sleep diaries and polysomnography, before and after one month of stable pregabalin dosage. Additionally, brain connectivity and volume changes will be evaluated using fMRI to understand the impact of pain and sleep disturbances.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Chronic (duration \> 3 months) painful peripheral neuropathy
* Pain moderate to severe (NRS ≥ 4/10) during the past week

Exclusion Criteria:

* psychotic depression, clinically significant bipolar disorder
* contraindication for performing brain fMRI (metal in the body etc)

Where it's running

• Helsinki University Central Hospital
  Helsinki, Hus, Finland Recruiting
• Helsinki University Hospital, Department of Neurology
  Helsinki, Uusimaa, Finland Recruiting

Study contacts

• Study coordinator: Hanna Harno, PhD
• Email: hanna.harno@hus.fi
• Phone: +358503427375

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.