Hematological clues and how patients respond to nerve blocks for neuropathic pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, non-interventional study conducted at a single center to explore whether routine blood test inflammation indices reflect treatment response in adults with neuropathic pain receiving sympathetic nerve blocks as part of standard care. Researchers will measure markers such as NLR, PLR, MLR, SII, SIRI, AISI, and RDW before and after the procedure over three months, and relate changes to pain scores and analgesic use. The study uses clinical assessments like NRS, DN4 or LANSS, Global Perceived Effect, and patterns of analgesic consumption to gauge outcomes. The approach is observational and aims to identify potential blood-based biomarkers associated with treatment response. Results could inform future trials and patient monitoring strategies in neuropathic pain management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Diagnosis of neuropathic pain based on clinical evaluation
* DN4 and/or LANSS scores compatible with neuropathic pain
* Undergoing sympathetic nerve block as part of routine clinical treatment
* Availability of pre-treatment and follow-up hemogram parameters
* Ability to provide written informed consent

Exclusion Criteria:

* Age \<18 years
* Active infection or acute inflammatory disease
* Active malignancy
* History of hematological disease
* Immunosuppressive therapy or systemic corticosteroid use
* Major surgery or severe trauma within the last month
* Pregnancy or breastfeeding
* Autoimmune or rheumatologic inflammatory disease
* Missing follow-up data

Where it's running

• Ankara Bilkent City Hospital
  Ankara, Cankaya, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Ülkü Sabuncu, Assoc prof
• Email: sabuncuulku@gmail.com
• Phone: 905337085212

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.