Home-based cortical stimulation for chronic neuropathic pain relief

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to evaluate the effectiveness of transcranial direct current stimulation (tDCS) in alleviating chronic neuropathic pain in patients who have not responded to conventional medications. The study will assess the analgesic effects of tDCS when administered at home, focusing on the importance and duration of pain relief achieved through repeated sessions over several weeks. By utilizing a non-invasive approach, the study seeks to improve the efficiency of pain management for individuals suffering from long-term neuropathic pain.

Why it matters

Who can join: the full rules

Inclusion Criteria :

* Patients from 18 to 80 years old, men or women, suffering pharmaco-resistant neuropathic chronic pain for more than one year; NVS \> 2 during the week S0) unilateral pharmacoresistant, whose analgesic treatment is stable for at least 1 month.
* Patients whose pharmacoresistance leads their referent doctor to consider non-pharmacological therapeutic alternatives and begin a presurgical assessment.
* Patients having an operational Internet connection. The patient or one person of its circle of acquaintances will have to be able to connect on the Internet and to reach by this way the system of relocated stimulation ("The Cloud").
* Patients having shown pain relief to a single- or whole-week sessions of tDCS are not excluded from potential recruitment for this study.
* Patients having a social security cover.
* Patients having given their written consent.

Exclusion Criteria :

* History
* of addiction to drugs,
* of epilepsy.
* Présence of an intra-cranial ferromagnetic equipment or of an implanted stimulation device (e.g. stimulating, central grey pacemaker, stimulation of the basal ganglia or of the vagus nerve).
* Introduction of a new analgesic treatment for less than a month.
* Lack of a effective contraception for all the duration of the study for the patients old enough to procreate.

(No limitation in the inclusion of male patients old enough to procreate).

* Patient under legal protective measure.
* Pregnant women and nursing mothers

Where it's running

• Hospices Civils de Lyon - Neurological Hospital - University Pain Clinic (CETD)
  Bron, France Recruiting

Study contacts

• Study coordinator: Luis Garcia-Larrea, Doctor
• Email: larrea@univ-lyon1.fr
• Phone: 4 72 35 78 88

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Neuropathic Pain Severity in Lumbar Spinal Stenosis and Its Link to Radiology

  This study will test how severe neuropathic pain is in adults with lumbar spinal stenosis and see if it relates to MRI findings and other clinical features.

  Recruiting Marmara University · Istanbul, Istanbul · NCT07855445

• Virtual Reality-Based Hypnotherapy to Help Pain, Sleep, and Mood in Spinal Cord Injury

  Adults with spinal cord injury will try adding short VR-based hypnotherapy sessions to their standard physiotherapy to see if it reduces pain and improves sleep and mood.

  Recruiting Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Istanbul, Istanbul · NCT07846410

• Extended-release Pregabalin for nerve pain from diabetes or shingles

  This phase 3 study tests an extended-release form of pregabalin to see if it reduces nerve-pain symptoms in adults with diabetic neuropathy or postherpetic neuralgia.

  Recruiting at 15 sites Phase 3 Brainfarma Industria Química e Farmacêutica S/A · Salvador, Estado de Bahia and 14 other locations · NCT07712913

• High-Intensity Peripheral Magnetic Stimulation for Traumatic Nerve Injury

  This study tests whether adding high-intensity peripheral magnetic stimulation to a structured exercise program can reduce pain and improve function for adults with a traumatic peripheral nerve injury.

  Recruiting Gaziler Physical Medicine and Rehabilitation Education and Research Hospital · Ankara · NCT07705490

• Hematological clues and how patients respond to nerve blocks for neuropathic pain

  This study looks at blood inflammation markers to see if they relate to how well people with neuropathic pain respond to sympathetic nerve blocks.

  Recruiting Ankara City Hospital Bilkent · Ankara, Cankaya · NCT07596823

• Cord plasma eye drops to treat neuropathic corneal pain

  This trial will test whether cord plasma eye drops can reduce long-lasting nerve-related corneal pain in people with evidence of corneal nerve damage.

  Recruiting Singapore Eye Research Institute · Singapore, Singapore · NCT07566806

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.