Neuropathic pain after childhood amputation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This monocentric observational study uses a mixed retrospective and prospective design to document phantom limb pain and residual limb pain in children and adolescents who underwent limb amputation during childhood. Data are collected from medical records and age-appropriate standardized questionnaires administered at routine follow-up visits at a specialized pediatric limb anomaly center. The study also measures quality of life and functional autonomy and explores associations with age at amputation and surgical history. Results aim to clarify the prevalence, characteristics, and everyday impact of neuropathic pain in this rare population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged between 5 and 18 years (inclusive) (Piaget's concrete operational stage to be able to complete the self-assessment questionnaires)
* Patients who underwent amputation before the age of 15 for girls and 16 for boys (average age of completion of lower limb growth)
* Patients who have not undergone surgery on the amputated limb for at least one year (to avoid bias, as any surgery involving incision can cause temporary neuropathic pain unrelated to the amputation)
* Have obtained the signature of the non-objection form by both parents/legal guardians
* Have obtained the child's consent (verbal consent but recorded)
* Be affiliated with a health insurance plan.

Exclusion Criteria:

* Patients who do not speak French
* Patients whose cognitive abilities are insufficient (as determined by a clinician or reported by parents) to be able to complete self-assessment questionnaires
* Patients undergoing chemotherapy (due to transient neuropathic pain)
* Patients who have received chemotherapy and whose side effects have not yet subsided (on a case-by-case basis depending on the chemotherapy used)
* Patients who have received chemotherapy causing neuropathic pain due to this treatment that has not disappeared.
* Patients placed under protective custody.

Where it's running

• Hôpitaux Paris Est Val-de-Marne - Centre de Référence des Malformations des Membres
  Saint-Maurice, France Recruiting

Study contacts

• Principal investigator: Margaux MM Modjbafan — Hôpitaux Paris Est Val-de-Marne, centre de référence des malformations des membres, Saint-Maurice 94410
• Study coordinator: Auriane AS SLAMA
• Email: auriane.slama@ght94n.fr
• Phone: +33143967556

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.