Combining rTMS with virtual reality mirror therapy for neuropathic pain relief

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project investigates the effects of combining repetitive transcranial magnetic stimulation (rTMS) with virtual reality mirror therapy on individuals suffering from neuropathic pain. Neuropathic pain is challenging to treat with conventional medications, and this study aims to enhance the analgesic effects of rTMS by integrating it with a novel therapeutic approach. The study will assess daily pain intensity, quality of life, and brain activity to determine the efficacy of this combined treatment. It represents a pioneering effort to explore the synergistic potential of these two non-invasive neuromodulation techniques.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical symptoms typical of neuropathic pain
* Refractory to drug therapies
* Lasting for at least 6 months, with a moderate to severe pain intensity (≥4/10 on Visual Analog Scale, VAS) and a stable pain treatment since 1month at least
* Having right to health benefits

Exclusion Criteria:

* Ferromagnetic components and implanted microprocessors (i.e. cochlear implants)
* Drug-resistant or active epilepsy, pacemaker, pregnancy, ongoing depression or personality troubles, and ongoing opioid treatment.
* Any other contraindications to MRI scanner (e.g., claustrophobia, etc.).

Where it's running

• Centre Hospitalier Universitaire de Saint-Etienne
  Saint-Etienne, France Recruiting
• Hôpital Neurologique Pierre Wertheimer
  Bron, France Not yet recruiting

Study contacts

• Principal investigator: Roland Peyron, MDPHD — Centre Hospitalier de Saint-Etienne
• Study coordinator: Roland Peyron, MDPHD
• Email: roland.peyron@univ-st-etienne.fr
• Phone: (0)477825684

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Neuropathic Pain Severity in Lumbar Spinal Stenosis and Its Link to Radiology

  This study will test how severe neuropathic pain is in adults with lumbar spinal stenosis and see if it relates to MRI findings and other clinical features.

  Recruiting Marmara University · Istanbul, Istanbul · NCT07855445

• Virtual Reality-Based Hypnotherapy to Help Pain, Sleep, and Mood in Spinal Cord Injury

  Adults with spinal cord injury will try adding short VR-based hypnotherapy sessions to their standard physiotherapy to see if it reduces pain and improves sleep and mood.

  Recruiting Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Istanbul, Istanbul · NCT07846410

• Extended-release Pregabalin for nerve pain from diabetes or shingles

  This phase 3 study tests an extended-release form of pregabalin to see if it reduces nerve-pain symptoms in adults with diabetic neuropathy or postherpetic neuralgia.

  Recruiting at 15 sites Phase 3 Brainfarma Industria Química e Farmacêutica S/A · Salvador, Estado de Bahia and 14 other locations · NCT07712913

• High-Intensity Peripheral Magnetic Stimulation for Traumatic Nerve Injury

  This study tests whether adding high-intensity peripheral magnetic stimulation to a structured exercise program can reduce pain and improve function for adults with a traumatic peripheral nerve injury.

  Recruiting Gaziler Physical Medicine and Rehabilitation Education and Research Hospital · Ankara · NCT07705490

• Hematological clues and how patients respond to nerve blocks for neuropathic pain

  This study looks at blood inflammation markers to see if they relate to how well people with neuropathic pain respond to sympathetic nerve blocks.

  Recruiting Ankara City Hospital Bilkent · Ankara, Cankaya · NCT07596823

• Cord plasma eye drops to treat neuropathic corneal pain

  This trial will test whether cord plasma eye drops can reduce long-lasting nerve-related corneal pain in people with evidence of corneal nerve damage.

  Recruiting Singapore Eye Research Institute · Singapore, Singapore · NCT07566806

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.