Understanding a specific receptor for neuropathic pain relief
α9α10 Nicotinic Acetylcholine Receptors in neuropathic pain
This project aims to find new, safer ways to treat chronic neuropathic pain by focusing on a specific target in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11143249 on NIH RePORTER |
What this research studies
Many people experience chronic neuropathic pain, which often doesn't respond well to current treatments, including opioids that carry risks. We are working to understand a particular target in the body, called the α9α10 nicotinic acetylcholine receptor, that plays a role in this type of pain. Our goal is to develop new medications that can block this receptor, offering a non-opioid option for effective pain relief. This approach could lead to safer and more effective treatments for those living with neuropathic pain.
Who could benefit from this research
Good fit: This research is ultimately for individuals who suffer from chronic neuropathic pain and are seeking better treatment options.
Not a fit: Patients who do not experience neuropathic pain or whose pain is well-managed by existing treatments may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new, non-opioid medications that effectively and safely treat chronic neuropathic pain.
How similar studies have performed: Previous work in animal models has shown that blocking this receptor can reduce pain symptoms, suggesting a promising path forward.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Riley, Andrew — University of Illinois at Chicago
- Study coordinator: Riley, Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.