Comparing different NSAIDs plus home exercises for frozen shoulder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18–75 with primary frozen shoulder and at least one month of shoulder pain will be enrolled at Konya Beyhekim Training and Research Hospital and randomized to receive one of several NSAIDs (diclofenac, meloxicam, or indomethacin) alongside a home-based shoulder exercise program. Investigators will record sociodemographic data, detailed clinical and examination findings, imaging where relevant, and baseline outcome measures before treatment. Patients' pain phenotypes will be classified as nociceptive, neuropathic, or nociplastic using clinical history and questionnaires, and block randomization will assign about 120 participants to chemically distinct NSAID groups. Outcomes will compare pain, range of motion, and function across drug groups and pain phenotypes to identify which combinations produce greater symptom improvement.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Being between 18-75 years of age
2. Having shoulder pain that has lasted for at least one month and being diagnosed with primary frozen shoulder
3. Having a VAS pain level ≥ 4/10
4. Having ≥30 degrees of range of motion restriction in at least two planes (flexion, abduction, or external rotation)
5. Not having any exclusion criteria and agreeing to participate in the study voluntarily

Exclusion Criteria:

1. Patients with a history of shoulder trauma, those with musculoskeletal disorders characterized by pain and loss of function in the affected extremity (such as lateral epicondylitis, flexor tendon injury, de Quervein's tenosynovitis)
2. Presence of neurological involvement such as stroke, brachial plexus injury, Parkinson's disease, and cervical spine injury with or without radiculopathy
3. History of shoulder surgery, malignancy or tumor in the shoulder, those who have undergone shoulder manipulation
4. Presence of shoulder arthritis, rotator cuff tear or other shoulder injuries, thoracic outlet syndrome
5. Systemic disease affecting the shoulder region, severe degeneration or trauma (e.g., osteoarthritis, rheumatoid arthritis, history of labrum or articular cartilage injuries), inflammatory rheumatic diseases
6. Those who have received steroid injections into the affected extremity within the last 3 months, those using oral steroids or NSAIDs, those receiving any surgical or interventional treatment, or Planned individuals:
7. Those who are pregnant or lactating
8. Those with uncontrolled diabetes, heart failure, uncontrolled systemic disease (liver disease, chronic kidney failure, significant endocrine disorders, etc.)
9. Those with communication problems, severe psychiatric disorders
10. Those allergic to NSAIDs or with any contraindications
11. Those with bleeding, coagulation disorders, stomach ulcers, or symptomatic gastritis

Where it's running

• Konya Beyhekim Training and Research Hospital
  Konya, Selçuklu, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Rukiye Hilal Taygurt Md., principal investigator
• Email: rukiyehilalgokce@gmail.com
• Phone: +905389122141

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Home-use brain stimulation (tDCS) for chronic neuropathic or nociplastic pain

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.