Cord plasma eye drops to treat neuropathic corneal pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center interventional trial at the Singapore Eye Research Institute testing topical cord plasma eye drops in patients with neuropathic corneal pain lasting at least three months and corneal nerve abnormalities on in vivo confocal microscopy. Participants receive cord plasma eye drops and are followed for changes in pain symptoms, corneal nerve imaging (IVCM), and tear mediators to explore both clinical effect and mechanisms. Key eligibility requires persistent neuropathic symptoms, minimal surface staining, and imaging evidence of nerve damage; active ocular surface infection or epithelial defects are excluded. The study aims to determine whether the drops provide neurotrophic and anti-neuroinflammatory benefit beyond standard dry eye treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Persistent ocular pain or pain-like symptoms, including burning sensation, allodynia, photoallodynia, stinging, hyperalgesia, throbbing, shooting, sharp, cramping, gnawing, or a feeling of electric shock, with a minimum score of 30% for more than 3 questions in the OPAS questionnaire (see below section for OPAS questionnaire), for at least 3 months;
2. Presence of corneal nerve abnormalities, including microneuromas, beading, nerve tortuosity, decreased in corneal nerve fiber density (CNFD) or corneal nerve fiber length (CNFL), on IVCM images;
3. Minimal or no ocular surface fluorescein staining, with the National Eye Institute (NEI) and ocular surface Oxford score \<2;
4. Patients who will receive cord plasma eye drops treatment

Exclusion Criteria:

1. Presence of active ocular surface diseases, such as active infective keratitis, the presence of epithelial defect or any other conditions that may cause nociceptive pain
2. Active anterior or posterior blepharitis;
3. Presence of concomitant ocular diseases that may cause ocular pain, such as uveitis or other ocular inflammatory diseases;
4. Concurrent treatment with immunosuppressants, such as topical cyclosporin or steroid eye drops
5. Concurrent use of oral Nonsteroidal anti-inflammatory drugs (NSAID) or other medications that may affect the pain scores

Where it's running

• Singapore Eye Research Institute
  Singapore, Singapore, Singapore Recruiting

Study contacts

• Study coordinator: Yu-Chi Liu, PhD
• Email: liu.yu.chi@snec.com.sg
• Phone: 65 65767493

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.