Using Transcranial Magnetic Stimulation to Treat Neuropathic Pain from Spinal Cord Injuries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of high-frequency Repetitive Transcranial Magnetic Stimulation (rTMS) therapy on neuropathic pain, depression, quality of life, and sleep in individuals with spinal cord injuries. Participants will undergo different rTMS protocols targeting either the dorsolateral prefrontal cortex or the primary motor cortex, alongside a placebo group. Initial assessments will include various questionnaires to evaluate pain and quality of life, with follow-up assessments conducted two months after treatment. The study aims to determine the efficacy of rTMS as a non-invasive treatment option for managing neuropathic pain.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Aged 18-75 years Physician-diagnosed spinal cord injury for at least 3-months Neuropathic pain for at least 3-months Pain not attributable to any other conditions

Exclusion Criteria:

* Having an important comorbid disease such as severe heart disease (aortic stenosis, angina, hypertrophic cardiomyopathy, uncontrolled hypertension,arrhythmia, pacemaker)
* Neurodegenerative disease
* Epilepsy
* History of antiepileptic drug use
* Cognitive dysfunction
* Lower extremity peripheral nerve injury
* Increased intracranial pressure or uncontrolled migraine
* Infection on the skin in the application area.
* Having a brain lesion or a history of drug use that will affect the seizure threshold.

Any TMS-related contraindications, for example:

* Pacemaker
* Metallic implant
* Previous seizure
* Psychiatric disorders (excluding depression and anxiety)
* Malignancy
* Current pregnancy

Where it's running

• Afyonkarahisar Health Sciences University
  Afyonkarahisar, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Nuran Eyvaz, MD — Afyonkarahisar Health Sciences University
• Study coordinator: Ayse Kalender, MD
• Email: aysebuber007@gmail.com
• Phone: +905389563559

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• New treatment for neuropathic pain in spinal cord injury patients

  This study is testing a new oral medication called EC5026 to see if it can safely help people with spinal cord injuries manage their nerve pain.

  Recruiting Phase 1 EicOsis Human Health Inc. · Augusta, Georgia · NCT06438471

• Virtual reality walking game for neuropathic pain relief in spinal cord injury patients

  This study tests if a virtual reality walking game can help adults with spinal cord injuries and ongoing nerve pain feel better.

  Recruiting Texas A&M University · College Station, Texas · NCT06330181

• Using body illusions and brain stimulation to treat pain in spinal cord injury

  This study is testing if combining body illusions with a type of brain stimulation can help reduce pain and improve sensation in people with spinal cord injuries.

  Recruiting University of Miami · Miami, Florida · NCT06010251

• Using Transcranial Magnetic Stimulation to Treat Neuropathic Pain in Spinal Cord Injury Patients

  This study is testing whether a type of brain stimulation called rTMS can help reduce neuropathic pain in people with spinal cord injuries.

  Recruiting Afyonkarahisar Health Sciences University · Afyonkarahisar · NCT05645003

• Training leg reflexes to reduce neuropathic pain after spinal cord injury

  This study is testing whether training leg reflexes can help reduce neuropathic pain in people with spinal cord injuries.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05492188

• Using virtual reality walking games to help with neuropathic pain in spinal cord injury patients

  This study is testing whether playing virtual reality walking games can help adults with spinal cord injuries and ongoing nerve pain feel better.

  Recruiting at 2 sites Texas A&M University · Birmingham, Alabama and 2 other locations · NCT05005026

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.