Using capsaicin patches to treat painful hand osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicentric, randomized controlled double-blind clinical trial aims to evaluate the efficacy of a transdermal capsaicin patch (8%) compared to a lower dose (0.04%) in patients suffering from painful digital osteoarthritis with a neuropathic pain component. Participants will be randomly assigned to receive either the higher concentration capsaicin patch or the control patch, and their pain levels will be assessed at 60 days. The study will also involve monitoring the use of analgesics and measuring inflammatory markers through blood samples. The goal is to determine if the higher dose of capsaicin can significantly reduce pain compared to the lower dose.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of digital osteoarthritis fulfilling the American College of Rheumatology criteria;
* Presence of finger pain of ≥ 40 mm on a visual analogue scale (VAS);
* Presence of finger pain with a neuropathic pain component (DN4 score ≥ 4/10)
* Inadequate response, adverse reactions, and/or contraindications to conventional analgesics and NSAIDs;

Exclusion Criteria:

* Patient with isolated rhizarthrosis;
* Patient with other joint disease affecting the fingers (gout, chondrocalcinosis, RA, spondyloarthritis, psoriatic arthritis);
* Patient with upper extremity pain syndrome that may interfere with the assessment of finger pain;
* Patient with another pathology responsible for neuropathic hand pain (carpal tunnel syndrome, diabetic neuropathy, Guyon's tunnel syndrome, cervicobrachial neuralgia, brachial plexitis);
* Patient with skin lesions on the fingers (psoriasis, wounds, chronic ulcers, eczema, shingles, dermatitis);
* Patient with poorly controlled high blood pressure;
* Patient with hypersensitivity to capsaicin;
* Patient who had 8% capsaicin patch use in the year prior to the study;
* Patient who has received intramuscular, intra-articular or intravenous corticosteroid therapy, another disease-modifying anti-rheumatic therapy (methotrexate, salazopyrine) or an intra-articular injection into the joints of the fingers within the previous 3 months;
* Patient wearing wrist or finger orthoses in the previous month;
* Patient with fibromyalgia;

Where it's running

• CHU de Clermont-Ferrand
  Clermont-Ferrand, France Recruiting
• HCL Hôpital Edouard Herriot
  Lyon, France Recruiting
• AP-HP Hôpital Saint-Antoine
  Paris, France Recruiting
• CHU de Saint-Etienne
  Saint-Etienne, France Recruiting

Study contacts

• Principal investigator: Sylvain Mathieu — University Hospital, Clermont-Ferrand
• Study coordinator: Lise Laclautre
• Email: promo_interne_drci@chu-clermontferrand.fr
• Phone: 334.73.754.963

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Neuropathic Pain Severity in Lumbar Spinal Stenosis and Its Link to Radiology

  This study will test how severe neuropathic pain is in adults with lumbar spinal stenosis and see if it relates to MRI findings and other clinical features.

  Recruiting Marmara University · Istanbul, Istanbul · NCT07855445

• Virtual Reality-Based Hypnotherapy to Help Pain, Sleep, and Mood in Spinal Cord Injury

  Adults with spinal cord injury will try adding short VR-based hypnotherapy sessions to their standard physiotherapy to see if it reduces pain and improves sleep and mood.

  Recruiting Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Istanbul, Istanbul · NCT07846410

• Extended-release Pregabalin for nerve pain from diabetes or shingles

  This phase 3 study tests an extended-release form of pregabalin to see if it reduces nerve-pain symptoms in adults with diabetic neuropathy or postherpetic neuralgia.

  Recruiting at 15 sites Phase 3 Brainfarma Industria Química e Farmacêutica S/A · Salvador, Estado de Bahia and 14 other locations · NCT07712913

• High-Intensity Peripheral Magnetic Stimulation for Traumatic Nerve Injury

  This study tests whether adding high-intensity peripheral magnetic stimulation to a structured exercise program can reduce pain and improve function for adults with a traumatic peripheral nerve injury.

  Recruiting Gaziler Physical Medicine and Rehabilitation Education and Research Hospital · Ankara · NCT07705490

• Hematological clues and how patients respond to nerve blocks for neuropathic pain

  This study looks at blood inflammation markers to see if they relate to how well people with neuropathic pain respond to sympathetic nerve blocks.

  Recruiting Ankara City Hospital Bilkent · Ankara, Cankaya · NCT07596823

• Cord plasma eye drops to treat neuropathic corneal pain

  This trial will test whether cord plasma eye drops can reduce long-lasting nerve-related corneal pain in people with evidence of corneal nerve damage.

  Recruiting Singapore Eye Research Institute · Singapore, Singapore · NCT07566806

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.