Condition

Shoulder Pain clinical trials and research

• 45Clinical trials
• 4NIH research projects
• 2New in 30 days
• 16Countries

Newest Shoulder Pain clinical trials

All recruiting trials (45)

• Functional electrical stimulation plus shoulder exercises for older adults with rotator cuff pain

  In older adults with rotator cuff–related shoulder pain, this study tests whether adding functional electrical stimulation to a shoulder exercise program improves muscle coordination and reduces impingement compared with exercises alone.

  Recruiting University of Texas at Austin · Austin, Texas · NCT07886827

• Shoulder pain patients: see if breathing and chest exercises help pain and sleep

  This study tests whether adding respiratory muscle strengthening and diaphragmatic breathing to shoulder rehab can reduce pain and improve sleep in adults with chronic shoulder pain.

  Recruiting Zonguldak Bulent Ecevit University · Zonguldak · NCT07885215

• Night Pain Module for Rotator Cuff-Related Shoulder Pain

  Researchers are testing a short set of questions to measure night pain in people with rotator cuff–related shoulder pain to see if it reliably describes how sleep is affected.

  Recruiting at 3 sites Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Istanbul and 2 other locations · NCT07838233

• Nociplastic Pain in SAPS: A Look at Pain Types in Shoulder Pain

  This study tests how common nociplastic pain is among people with subacromial pain syndrome who have shoulder pain for at least 3 months.

  Recruiting Vejle Hospital · Vejle · NCT07792434

• Pain phenotype and response to corticosteroid injection in SAPS

  This study tests whether people with subacromial pain syndrome who have a nociplastic pain pattern respond differently to a corticosteroid injection than those without that pattern.

  Recruiting Vejle Hospital · Vejle · NCT07792421

• Spinal and Kaltenborn mobilization for a stiff shoulder (frozen shoulder)

  A randomized trial tests spinal mobilization with arm movement and Kaltenborn mobilization to see if they reduce pain and improve motion and function in people with adhesive capsulitis.

  Recruiting at 2 sites Riphah International University · Lahore, Punjab Province and 1 other locations · NCT07724691

• Dexmedetomidine as an add-on to bupivacaine for a nerve block around the shoulder

  This trial tests whether adding dexmedetomidine to bupivacaine for a PENG nerve block improves pain control after shoulder surgery in adults.

  Recruiting Kasr El Aini Hospital · Cairo · NCT07626346

• Effects of fascia correction taping on shoulder pain and mobility

  In people with Subacromial Impingement Syndrome, this study tests whether fascia correction Kinesio Taping on the thoracolumbar area improves shoulder pain and mobility compared with sham taping.

  Recruiting Hacettepe University · Ankara, Altindag · NCT07624136

• Shoulder and trunk movement and muscle activity during the tennis serve in players with shoulder pain

  This study tests whether shoulder and trunk movements and shoulder muscle activity during the tennis serve differ between amateur tennis players with subacromial pain syndrome or a history of shoulder pain and those without pain.

  Recruiting National Yang Ming Chiao Tung University · Taipei · NCT07543484

• Comparing different NSAIDs plus home exercises for frozen shoulder

  This will test whether taking one of several NSAIDs (diclofenac, meloxicam, or indomethacin) together with home shoulder exercises helps adults aged 18–75 with frozen shoulder and whether pain type changes the benefit.

  Recruiting Konya Beyhekim Training and Research Hospital · Konya, Selçuklu · NCT07493226

• Ultrasound-guided shoulder injections for frozen shoulder

  This tests whether adding ultrasound-guided suprascapular nerve block, with or without a subacromial injection, to a home exercise program reduces pain and improves shoulder function in adults with chronic frozen shoulder.

  Recruiting Konya Beyhekim Training and Research Hospital · Konya, Selçuklu · NCT07493213

• Short-term supraspinatus tendon changes after two shoulder exercise sessions.

  This study will test whether two different 15-minute shoulder exercise programs cause short-term tendon changes in adults with and without shoulder pain.

  Recruiting University of Florida · Gainesville, Florida · NCT07489937

• Early-Phase Graded Motor Imagery after Massive Rotator Cuff Repair

  This study tests whether graded motor imagery can help people recover motor control and reduce pain after a large rotator cuff repair.

  Recruiting Acibadem University · Istanbul, Turkey · NCT07481864

• Contextually Enhanced Exercise Program for Rotator Cuff‑Related Shoulder Pain

  This trial tests whether adding personalized contextual factors to a proven exercise program helps people with rotator cuff–related shoulder pain feel less pain and move better.

  Recruiting Istanbul Nisantasi University · Istanbul · NCT07428070

• Interscalene versus anterior suprascapular nerve blocks to prevent shoulder pain after open lung surgery

  This trial will test whether adding an ultrasound-guided interscalene block or an anterior suprascapular block to epidural anesthesia reduces shoulder pain after thoracotomy in adults with lung cancer.

  Recruiting National Cancer Institute, Egypt · Cairo · NCT07424638

• Bupivacaine with Epinephrine Sprayed Under the Diaphragm During Laparoscopy

  This study tests whether spraying bupivacaine with epinephrine under the diaphragm during laparoscopic gynecologic surgery reduces postoperative shoulder pain.

  Recruiting Phase 4 Cedars-Sinai Medical Center · Los Angeles, California · NCT07400146

• Ultrasound-guided serratus posterior superior intercostal plane (SPSIP) block for shoulder arthroscopy pain

  This will test whether an ultrasound-guided serratus posterior superior intercostal plane (SPSIP) block reduces pain after arthroscopic shoulder surgery.

  Recruiting Bursa City Hospital · Bursa, Bursa · NCT07394673

• Rigid taping for acromioclavicular (AC) joint degeneration

  We will try rigid taping plus a standard exercise program to see if it reduces shoulder pain and improves motion and function in adults aged 18–65 with imaging-confirmed AC joint degeneration.

  Recruiting Hacettepe University · Ankara, Ankara · NCT07333417

• Kettlebell training for rotator cuff–related shoulder pain

  This trial tests whether 8 weeks of kettlebell training can reduce pain and improve function and performance in people with rotator cuff–related shoulder pain.

  Recruiting Hacettepe University · Ankara and 1 other locations · NCT07289893

• Interscalene block versus serratus posterior superior intercostal plane block for pain after arthroscopic shoulder surgery

  This will test whether a newer serratus posterior superior intercostal plane block works as well as the standard interscalene block for people having arthroscopic shoulder surgery.

  Recruiting Medipol University · Istanbul, Bagcilar · NCT07278050

• High-intensity interval training for persistent inflammatory shoulder pain

  This study will try short sessions of high-intensity interval training (HIIT) in adults with long-term shoulder pain thought to be driven by low-grade inflammation to see if the exercise is acceptable and whether inflammation and pain-related measures change.

  Recruiting Universiteit Antwerpen · Wilrijk · NCT07275164

• Comparing high versus low electrical frequencies delivered through fine needles to improve shoulder muscle strength and pain sensitivity

  This trial will test whether high- or low-frequency percutaneous electrical nerve stimulation using fine needles helps improve shoulder muscle strength and increases pressure-pain thresholds in people with shoulder pain and a latent trigger point in the infraspinatus.

  Recruiting Universidad Complutense de Madrid · Krakow, Poland and 1 other locations · NCT07269925

• Does age-related muscle loss change rotator cuff tear patterns?

  We will see if age-related muscle loss (sarcopenia) is linked to the location and type of rotator cuff tears in adults aged 40–75 with rotator cuff syndrome.

  Recruiting Haydarpasa Numune Training and Research Hospital · Istanbul, Üsküdar · NCT07183774

• Acupuncture for pain after total knee replacement

  This project will try acupuncture to reduce short-term pain, opioid use, and inflammation after elective total knee replacement in adults.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Pavia · NCT07123805

• How common scapular dyskinesis is among Egyptian physical therapists

  This project will test how common scapular dyskinesis is in licensed Egyptian physical therapists aged 27–40 and whether it's linked to age, sex, BMI, shoulder/neck symptoms, or scapular muscle strength.

  Recruiting Cairo University · Cairo · NCT07123532

• Shoulder-focused versus whole-body physiotherapy for volleyball players with shoulder pain

  We will test whether shoulder-focused or whole-body physiotherapy helps volleyball players with shoulder pain more than education alone.

  Recruiting University of Trieste · Trieste, Trieste · NCT07072091

• Pulsed radiofrequency to shoulder nerves versus the brachial plexus for chronic post‑mastectomy shoulder pain

  This will test whether pulsed radiofrequency to the brachial plexus or to individual shoulder nerves helps reduce chronic shoulder pain after mastectomy.

  Recruiting Cairo University · Cairo · NCT07002944

• Evaluating the Zimmer Biomet Shoulder Replacement System

  This study is testing how safe and effective the Zimmer Biomet Shoulder Replacement System is for people getting shoulder surgery, looking at their pain, movement, and quality of life over two years.

  Recruiting at 2 sites Zimmer Biomet · Pforzheim and 1 other locations · NCT06920459

• Comparing scapular exercises to standard treatment for shoulder pain

  This study is testing if scapular exercises can help people with shoulder pain and scapular issues feel better than standard treatment.

  Recruiting Ankara Yildirim Beyazıt University · Ankara · NCT06890000

• Comparing ultrasound and fluoroscopy guidance for treating frozen shoulder

  This study is testing whether using ultrasound or fluoroscopy helps people with frozen shoulder get better pain relief and improved movement from a specific treatment.

  Recruiting Diskapi Teaching and Research Hospital · Ankara · NCT06888791

• Blood flow restriction training for shoulder pain

  This study is testing if a new training method that restricts blood flow can help people with shoulder pain feel better and improve their strength during physical therapy.

  Recruiting University of Florida · Gainesville, Florida · NCT06873113

• Using a serratus posterior superior intercostal plane block to reduce pain after arthroscopic shoulder surgery

  This trial will test whether an ultrasound-guided serratus posterior superior intercostal plane block can reduce postoperative pain and opioid use for adults having arthroscopic shoulder surgery under general anesthesia.

  Recruiting Kahramanmaras Sutcu Imam University · Istanbul, Bagcilar and 1 other locations · NCT06866054

• Using a digital tool to improve shoulder pain treatment in rural areas

  This study is testing if a digital tool called TRAK can help people in rural areas with shoulder pain get better treatment and feel more satisfied compared to regular at-home exercises.

  Recruiting Trak Health Solutions S.L. · Madrid · NCT06796309

• Photographic Shoulder Scale to show shoulder pain and daily activity limits

  This project will test a set of photos to help people with shoulder pain describe their pain and how it affects everyday activities.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT06718296

• Comparing manual therapy and shock wave treatment for shoulder pain

  This study is testing whether manual therapy or shock wave treatment is better at relieving shoulder pain for people with subacromial syndrome.

  Recruiting University of Alcala · Alcalá de Henares, Madrid · NCT06587399

• Evaluating dry needling effects on shoulder muscle activity

  This study is testing whether dry needling can improve muscle activity and reduce pain in people with and without shoulder pain by comparing real treatment to a fake one.

  Recruiting University of Alcala · Alcalá de Henares, Madrid · NCT06398574

• Effect of dry needling on shoulder pain

  This study is testing if dry needling can help people with shoulder pain feel better and improve their movement.

  Recruiting Kutahya Health Sciences University · Kütahya, Türkiye · NCT06338488

• Noninvasive treatment for shoulder pain linked to liver issues

  This study is testing a new noninvasive treatment for shoulder pain that might be linked to liver problems to see if it can help relieve the pain.

  Recruiting at 4 sites University of Seville · Seville, Sevilla and 3 other locations · NCT06296979

• Embolization treatment for chronic shoulder pain

  This study is testing if adding a special procedure called embolization to physical therapy can help people with ongoing shoulder pain from rotator cuff issues feel better compared to just doing physical therapy alone.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06095050

• Evaluating capsular repair technique for shoulder instability

  This study is testing a new shoulder surgery technique to see if it helps people with shoulder instability avoid developing arthritis in the long run.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Paris · NCT05978362

• Comparing mindfulness breathing and biofeedback for pain relief after shoulder surgery

  This study tests whether mindfulness breathing, biofeedback, or pain education can help people who are having shoulder surgery feel less pain and recover better.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT05917262

• Evaluating Zimmer Biomet Shoulder Replacement Systems

  This study is testing how safe and effective Zimmer Biomet Shoulder Replacement Systems are for people getting shoulder surgery, looking at how well the implants last over ten years and how patients feel after two years.

  Recruiting at 2 sites Zimmer Biomet · Irvine, California and 16 other locations · NCT04984291

• Using fat tissue injections to treat shoulder osteoarthritis

  This study is testing if injections of processed fat from your own body can help relieve shoulder pain and improve movement better than regular steroid shots for people with mild to moderate shoulder osteoarthritis.

  Recruiting Phase 1 Stanford University · Stanford, California · NCT04929951

• Evaluating hemidiaphragmatic paralysis after shoulder surgery with nerve blocks

  This study is testing how often patients having shoulder surgery with a specific nerve block experience breathing issues and how it affects their pain and use of pain medication afterward.

  Recruiting Duke University · Durham, North Carolina · NCT04209504

• Effect of integrated CAM treatment on hospitalized patients with musculoskeletal pain

  This study is testing whether a combined treatment of alternative therapies and regular medical care can help hospitalized patients with musculoskeletal pain feel better and improve their movement.

  Recruiting Jaseng Hospital of Korean Medicine · Seoul, Gangnam-Gu · NCT02257723

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Shoulder replacement patients: better pain care through personalized risk profiles

  A Duke-led project will look at how biological, psychological, and social factors together predict chronic pain after total shoulder replacement, with the goal of guiding personalized pain management.

  NIH research Duke University · Durham, United States · NIH-11399697

• Understanding and treating shoulder pain after a stroke

  This study is looking into why many stroke survivors have shoulder pain and how a substance called hyaluronic acid might be affecting their movement and comfort, with the goal of finding better ways to diagnose and treat this issue to help them feel better and recover more effectively.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11170291

• Predicting who develops long-term pain after total shoulder replacement using biological, psychological, and social factors

  This project looks for patterns in biology, emotions, and social circumstances that help predict which adults will still have pain one year after total shoulder replacement.

  NIH research Duke University · Durham, United States · NIH-11139609

• Understanding how biological, psychological, and social factors affect shoulder pain after surgery

  This study is looking at how various factors in your body, mind, and life can affect long-term pain after shoulder surgery, so we can find better ways to manage pain for each person based on their unique situation.

  NIH research Duke University · Durham, United States · NIH-10906219

Related topics

Quick answers

How many Shoulder Pain clinical trials are recruiting right now?

45, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in Turkey (Türkiye) (17 trials), United States (8 trials), Spain (4 trials), Egypt (4 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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