PEA and Scutellaria combined with exercise for chemotherapy-related nerve pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort in which adults with chemotherapy-induced peripheral neuropathy will be enrolled and followed while receiving post-market nutraceuticals and supervised exercise. Participants will be grouped to compare those receiving PEA plus Scutellaria with standardized therapeutic exercise against other treatment approaches. Outcomes will include patient-reported neuropathic pain severity and measures of nerve health over the follow-up period. The study uses a standardized exercise protocol (EXCAP) and requires a minimum opioid washout to limit confounding from opioid pain control.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years and older.
* Patients who have undergone chemotherapy treatment within the previous 6 months.
* Patients treated with PEA, Scutellaria, and standardized therapeutic exercise according to the EXCAP protocol from April 2025 to September 2025.
* Patients with a washout period from opioid-based analgesic therapy of at least 10 days or who are not receiving opioid-based analgesic therapy.
* Patients presenting with neuropathic pain (NRS ≥ 5).
* Patients able to provide written informed consent.

Exclusion Criteria:

* Patients younger than 18 years.
* Patients with hypersensitivity to PEA or any of the excipients listed in the Summary of Product Characteristics (SPC).
* Patients with diabetic pathology.
* Patients with severe hepatic impairment.
* Patients with severe disabilities that compromise the execution of therapeutic exercise.

Where it's running

• A.O.U.P. P. Giaccone, Palermo, Italia 90127
  Palermo, Italia, Italy Recruiting

Study contacts

• Study coordinator: Giulia Letizia Mauro
• Email: giulia.letiziamauro@unipa.it
• Phone: +39 0916554160 +39 09165541

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Closed-loop spinal cord stimulation for painful chemotherapy-induced peripheral neuropathy

  This observational project will try closed-loop spinal cord stimulation to reduce neuropathic pain in adults who developed peripheral neuropathy after chemotherapy.

  Recruiting at 5 sites Rijnstate Hospital · Arnhem and 4 other locations · NCT07304401

• Neuropathic Pain Severity in Lumbar Spinal Stenosis and Its Link to Radiology

  This study will test how severe neuropathic pain is in adults with lumbar spinal stenosis and see if it relates to MRI findings and other clinical features.

  Recruiting Marmara University · Istanbul, Istanbul · NCT07855445

• Virtual Reality-Based Hypnotherapy to Help Pain, Sleep, and Mood in Spinal Cord Injury

  Adults with spinal cord injury will try adding short VR-based hypnotherapy sessions to their standard physiotherapy to see if it reduces pain and improves sleep and mood.

  Recruiting Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Istanbul, Istanbul · NCT07846410

• Cryotherapy during weekly paclitaxel to reduce chemotherapy-induced numbness and tingling

  This study tests whether applying cryotherapy to hands and feet during weekly paclitaxel helps prevent CIPN in women with breast cancer.

  Recruiting at 3 sites Azienda Sanitaria dell'Alto Adige · Bolzano, Bolzano and 3 other locations · NCT07780955

• Extended-release Pregabalin for nerve pain from diabetes or shingles

  This phase 3 study tests an extended-release form of pregabalin to see if it reduces nerve-pain symptoms in adults with diabetic neuropathy or postherpetic neuralgia.

  Recruiting at 15 sites Phase 3 Brainfarma Industria Química e Farmacêutica S/A · Salvador, Estado de Bahia and 14 other locations · NCT07712913

• High-Intensity Peripheral Magnetic Stimulation for Traumatic Nerve Injury

  This study tests whether adding high-intensity peripheral magnetic stimulation to a structured exercise program can reduce pain and improve function for adults with a traumatic peripheral nerve injury.

  Recruiting Gaziler Physical Medicine and Rehabilitation Education and Research Hospital · Ankara · NCT07705490

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.