CBD-based formulation to relieve chemotherapy-induced nerve pain

Who could benefit from this research

What this research studies

This project explores a cannabidiol formulation aimed at reducing neuropathic pain from chemotherapy, a condition that can lead to dose reductions and affect cancer outcomes. Researchers are addressing how CBD can be made more soluble and bioavailable, and how it works with the body's nerves and immune system in the context of CIPN. The work builds on prior animal studies showing CBD’s potential to lessen neuropathic symptoms, with a focus on translating those findings toward human use. The study will advance understanding of how disease-specific mechanisms contribute to CIPN and how CBD might safely mitigate those effects in patients. Overall, the goal is to move closer to a preventive or therapeutic option for CIPN that improves quality of life for cancer patients.

Why it matters

Where this research is happening

• Temple Univ of the Commonwealth
  Philadelphia, United States Active

Researchers

• Principal investigator: Ward, Sara J — Temple Univ of the Commonwealth
• Study coordinator: Ward, Sara J

Related research

Other NIH-funded projects on the same topics.

• Safer non-opioid medicines for nerve pain from chemotherapy

  Testing new versions of the pain drug flupirtine to help people with chemotherapy-related nerve pain while lowering the risk of liver damage.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11267965

• Developing safer pain relief options for cancer patients experiencing neuropathic pain from chemotherapy

  This study is looking for safer pain relief options for cancer patients dealing with nerve pain from chemotherapy by creating new versions of an old medication, flupirtine, that was taken off the market due to safety issues.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11095629

• Identifying biomarkers for neuropathic pain caused by chemotherapy

  This study is looking at how certain biological markers in your body can help doctors figure out if you might experience nerve pain from chemotherapy before you start treatment, so they can tailor your care to reduce pain and improve your overall experience.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10914172

• New treatment for pain caused by chemotherapy

  This study is testing a new treatment called RFT1081 to help cancer patients who are dealing with painful nerve issues caused by chemotherapy, aiming to ease their pain without the usual side effects of pain meds.

  NIH research Raft Pharmaceuticals, LLC · San Diego, United States · NIH-10706551

• Photodynamic lipids to boost chemotherapy for metastatic ovarian cancer

  A patient-friendly approach tests a light-activated method to make ovarian cancer metastases more sensitive to chemotherapy.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11601571

• Peripheral nerve stimulation for chronic neuropathic pain in a new mechanistic trial

  A study at Stanford tests whether a painless-sounding electrical nerve treatment helps people with long-standing neuropathic pain when added to standard care.

  NIH research Stanford University · Stanford, United States · NIH-11579998

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.