Who is at risk for neuropathic pain during cancer care.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project follows adults with breast, gynecologic, colorectal, or lung cancer through one or more anti-cancer treatments and repeatedly collects cognitive-emotional and pain measures. Patients complete standardized questionnaires and clinical pain assessments before, during, and after therapies such as surgery, chemotherapy, radiotherapy, hormonal or targeted treatments. The study looks for patterns and risk factors — including preoperative pain intensity, opioid use, sleep disturbances, and psychological vulnerability — that predict development of chronic neuropathic pain. Results are intended to guide earlier prevention and more personalized pain-management strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria Patients:

* Patient over 18 years of age,
* Patient suffering from cancer (breast, gynecological, colorectal, lung) and having to undergo one or more anti-cancer therapeutic procedures (chemotherapy, surgery, hormonal therapy, radiotherapy, targeted therapy, etc.),
* Sufficient cooperation and understanding to comply with the study requirements,
* Agreement to give oral consent for the study,
* Affiliation with the French Social Security system.

Exclusion Criteria Patients:

* History of cancer and anti-cancer therapy (surgery, chemotherapy, radiotherapy, hormone therapy, targeted therapy, etc.),
* History and/or presence of primary brain tumors (glioblastoma, meningioma, neurofibroma, etc.) ),
* History of neurological disorders (Parkinson's disease, Alzheimer's disease, dementia, epilepsy, moderate to severe head trauma, etc.),
* Medical and/or surgical history judged by the investigator or his representative to be incompatible with the study,
* Subject whose cooperation and understanding do not allow strict compliance with the conditions laid down in the protocol,
* Pregnant or breast-feeding women,
* Beneficiary of a legal protection measure.

Inclusion Criteria Healthy Volunteers:

* Subject over 18 years of age,
* Subject free of any treatment in the 7 days preceding inclusion, in particular no use of analgesics, or judged by the investigator or his representative to be compatible with the study
* Subject with no history of cancer,
* Subject considered to be in good health by the investigator,
* Sufficient cooperation and understanding to comply with the study requirements,
* Agreement to give oral consent to the study,
* Affiliation with the French Social Security system,

Exclusion Criteria Healthy Volunteers:

* Subjects with a medical and/or surgical history judged by the investigator or his representative to be incompatible with the trial,
* Subjects whose cooperation and understanding do not allow strict compliance with the conditions laid down in the protocol,
* Pregnant or breast-feeding woman,
* Participating in another clinical trial, or within the exclusion period, or having received a total amount of compensation exceeding 4500 euros over the 12 months preceding the start of the trial,
* Benefiting from a legal protection measure.

Where it's running

• Centre Hospitalier d'Ajaccio
  Ajaccio, France Recruiting
• Centre de Lutte contre le Cancer - Institut de Cancérologie de l'Ouest
  Angers, France Recruiting
• Centre Hospitalier Henri Mondor d'Aurillac
  Aurillac, France Recruiting
• Centre de Lutte contre le Cancer - Institut Bergonié
  Bordeaux, France Recruiting
• Centre de Lutte contre le Cancer - Centre François Baclesse
  Caen, France Recruiting
• Centre Hospitalier Universitaire Caen Normandie
  Caen, France Recruiting

Study contacts

• Study coordinator: Lise LACLAUTRE
• Email: promo_interne_drci@chu-clermontferrand.fr
• Phone: 473754963

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.