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Who is at risk for neuropathic pain during cancer care.

Vulnerability and Risk of Neuropathic Pain in Cancer: Validation of a Predictive Tool to Optimize Treatment.

Not applicable Interventional University Hospital, Clermont-Ferrand · NCT06511674

We will try to use repeated cognitive-emotional and pain assessments to see who among adults with breast, gynecologic, colorectal, or lung cancer is likely to develop neuropathic pain during or after treatment.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment625 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity Hospital, Clermont-Ferrand Academic / other
Drugs / interventionschemotherapy
Locations19 sites (Ajaccio and 18 other locations)
Trial IDNCT06511674 on ClinicalTrials.gov

What this trial studies

This project follows adults with breast, gynecologic, colorectal, or lung cancer through one or more anti-cancer treatments and repeatedly collects cognitive-emotional and pain measures. Patients complete standardized questionnaires and clinical pain assessments before, during, and after therapies such as surgery, chemotherapy, radiotherapy, hormonal or targeted treatments. The study looks for patterns and risk factors — including preoperative pain intensity, opioid use, sleep disturbances, and psychological vulnerability — that predict development of chronic neuropathic pain. Results are intended to guide earlier prevention and more personalized pain-management strategies.

Who should consider this trial

Good fit: Adults (18+) with breast, gynecologic, colorectal, or lung cancer who are scheduled for one or more anti-cancer treatments, can understand and cooperate with study procedures, and are covered by the French social security system.

Not a fit: Patients with prior cancer treatments, primary brain tumors, significant neurological disorders, inability to comply with assessments, or those not covered by French social security or unable to attend participating centers are unlikely to benefit from this protocol.

Why it matters

Potential benefit: If successful, the approach could allow clinicians to identify high-risk patients early and offer targeted prevention or pain-control strategies to reduce chronic neuropathic pain.

How similar studies have performed: Previous observational studies have identified many risk factors and some predictive models for chronic cancer-related pain, but prediction of neuropathic pain specifically remains imperfect and needs further validation.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria Patients:

* Patient over 18 years of age,
* Patient suffering from cancer (breast, gynecological, colorectal, lung) and having to undergo one or more anti-cancer therapeutic procedures (chemotherapy, surgery, hormonal therapy, radiotherapy, targeted therapy, etc.),
* Sufficient cooperation and understanding to comply with the study requirements,
* Agreement to give oral consent for the study,
* Affiliation with the French Social Security system.

Exclusion Criteria Patients:

* History of cancer and anti-cancer therapy (surgery, chemotherapy, radiotherapy, hormone therapy, targeted therapy, etc.),
* History and/or presence of primary brain tumors (glioblastoma, meningioma, neurofibroma, etc.) ),
* History of neurological disorders (Parkinson's disease, Alzheimer's disease, dementia, epilepsy, moderate to severe head trauma, etc.),
* Medical and/or surgical history judged by the investigator or his representative to be incompatible with the study,
* Subject whose cooperation and understanding do not allow strict compliance with the conditions laid down in the protocol,
* Pregnant or breast-feeding women,
* Beneficiary of a legal protection measure.

Inclusion Criteria Healthy Volunteers:

* Subject over 18 years of age,
* Subject free of any treatment in the 7 days preceding inclusion, in particular no use of analgesics, or judged by the investigator or his representative to be compatible with the study
* Subject with no history of cancer,
* Subject considered to be in good health by the investigator,
* Sufficient cooperation and understanding to comply with the study requirements,
* Agreement to give oral consent to the study,
* Affiliation with the French Social Security system,

Exclusion Criteria Healthy Volunteers:

* Subjects with a medical and/or surgical history judged by the investigator or his representative to be incompatible with the trial,
* Subjects whose cooperation and understanding do not allow strict compliance with the conditions laid down in the protocol,
* Pregnant or breast-feeding woman,
* Participating in another clinical trial, or within the exclusion period, or having received a total amount of compensation exceeding 4500 euros over the 12 months preceding the start of the trial,
* Benefiting from a legal protection measure.

Where this trial is running

Ajaccio and 18 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Neuropathic PainCancerPredictive
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.