Condition

Amyotrophic Lateral Sclerosis clinical trials and research

• 95Clinical trials
• 65NIH research projects
• 2New in 30 days
• 30Countries

Newest Amyotrophic Lateral Sclerosis clinical trials

All recruiting trials (95)

• Implanted Brain-Computer Interface to Help People with Severe Arm Impairment

  We’re testing the N1 System, a fully implanted brain interface in the motor cortex with a robot, to see if it can help adults with spinal cord injury, ALS, or chronic stroke use a computer or keyboard more easily.

  Recruiting Neuralink Corp · Miami, Florida · NCT07929792

• Brain-computer interface chat tool for people with ALS

  This test compares a wearable brain-computer interface communication device to eye-tracking devices that people with ALS currently use to help them communicate.

  Recruiting Cognixion · Santa Barbara, California · NCT07871071

• BIIB147 safety and how it behaves in adults with ALS

  This study tests BIIB147 in adults with ALS to see if it is safe and how the body handles it, including early and long-term effects.

  Recruiting at 2 sites Phase 1/2 Biogen · St Louis, Missouri and 1 other locations · NCT07855211

• Aims to restore UNC13A function in people with ALS

  This trial tests TRCN-1023 in adults with ALS to see if it’s safe, tolerated, and shows early signs of benefit.

  Recruiting at 6 sites Phase 1/2 Trace Neuroscience, Inc. · Lübeck, Schleswig-Holstein and 5 other locations · NCT07674667

• LTX-002 in adults with ALS

  A study will test whether the experimental drug LTX-002 is safe and tolerable in adults with ALS and see how the body handles the drug and how it affects ALS indicators.

  Recruiting at 4 sites Phase 1/2 Leal Therapeutics, Inc · Lübeck and 4 other locations · NCT07660614

• Repeated ultrasound-assisted blood-brain barrier opening in ALS

  This trial tests whether repeatedly opening the blood-brain barrier with ultrasound is safe and may help people with ALS.

  Recruiting Phase 1/2 Assistance Publique - Hôpitaux de Paris · Paris · NCT07571486

• ALS master protocol with LY4256984 in eligible completers

  This study tests LY4256984 in people with ALS who completed a parent ALS study, to see if it is safe and tolerable over about 96 weeks.

  Recruiting at 2 sites Phase 1 Eli Lilly and Company · Leuven and 10 other locations · NCT07571200

• Long-term safety test of LY4256984 in ALS patients

  This long-term extension study will see if LY4256984 is safe and tolerable in people with ALS who completed the earlier trial.

  Recruiting at 2 sites Phase 1 Eli Lilly and Company · Leuven and 10 other locations · NCT07571174

• Using SleepImage to detect respiratory failure in people with ALS

  This project will try SleepImage monitoring during an overnight sleep recording to see if it can detect early respiratory failure in adults with ALS.

  Recruiting Royal Brompton & Harefield NHS Foundation Trust · London · NCT07502677

• How physical functioning relates to quality of life for people with ALS at TidalHealth

  This study will see if physical functioning scores relate to quality of life for adults with ALS who receive care at TidalHealth Peninsula Regional.

  Recruiting TidalHealth · Salisbury, Maryland · NCT07491484

• EH-301 and N-acetylcysteine with Riluzole for early ALS

  This will test whether adding EH-301 plus N-acetylcysteine to standard Riluzole can slow down or improve symptoms in people with ALS.

  Recruiting Phase 1/2 Biogipuzkoa Health Research Institute · San Sebastián, Guipuzcoa · NCT07414212

• Connexus® Brain-Computer Interface to restore communication and device control

  This study will try the Connexus brain-computer interface to help people with severe loss of voluntary movement (for example from ALS, cervical spinal cord injury, or stroke) communicate and control computers.

  Recruiting at 3 sites Paradromics · Sacramento, California and 2 other locations · NCT07357428

• Personalized physiotherapy using robotic leg-press guidance for people with ALS

  This study will try a personalized physiotherapy program guided by a robotic leg-press to see if it helps adults with ALS maintain physical function better than standard physiotherapy.

  Recruiting Cantonal Hospital of St. Gallen · Sankt Gallen · NCT07341984

• Blood RNA biomarkers for ALS using neuron-derived extracellular vesicles

  This will try to see if RNA signatures in neuron-derived extracellular vesicles from blood can identify biomarkers in adults with suspected sporadic ALS compared with healthy volunteers.

  Recruiting Fondation Ophtalmologique Adolphe de Rothschild · Paris · NCT07334743

• Pridopidine for adults with early, rapidly progressing ALS

  This trial will see if taking pridopidine 45 mg twice daily can slow disease progression in adults with early, rapidly progressing ALS.

  Recruiting at 56 sites Phase 3 Prilenia · Phoenix, Arizona and 55 other locations · NCT07322003

• Longitudinal integrated biomarker profiling linked to ALS clinical features

  This project will test whether repeated blood and spinal-fluid biomarker measurements combined with deep clinical profiling can help predict disease course in adults with ALS.

  Recruiting Istituto Auxologico Italiano · Milan, Lombardy · NCT07312240

• Needs of adults with the C9orf72 form of ALS and their caregivers

  This online survey will try to describe care and quality-of-life needs for adults with ALS who have the C9orf72 mutation and for their caregivers in Italy.

  Recruiting Istituto Auxologico Italiano · Milan, Lombardy and 2 other locations · NCT07302321

• Video-based proprioceptive home exercise for trunk and limb control in ALS

  This program will try a video-based proprioceptive home exercise routine for adults with ALS who can sit independently to see if it improves trunk and limb control and daily activities.

  Recruiting Tarsus University · Mersin, TARSUS · NCT07292545

• Single intrathecal injection of INS1202 for adults with ALS (SOD1 or no known mutation)

  This study will try a single injection of INS1202 into the spinal fluid to see if it is safe and how it acts in adults with ALS who have SOD1 mutations or no known ALS gene mutation.

  Recruiting at 9 sites Phase 1 Insmed Incorporated · Phoenix, Arizona and 8 other locations · NCT07290062

• Safety and tolerability of VTx-002 given into the cisterna in people with ALS

  This trial will test a single intracisternal injection of VTx-002 to see if it is safe and tolerated in adults with ALS.

  Recruiting at 7 sites Phase 1/2 Vector Y Therapeutics · Phoenix, Arizona and 8 other locations · NCT07287397

• Long-term safety monitoring of tofersen (Qalsody) in people with SOD1 ALS

  This project will see how safe tofersen (Qalsody) is over time in people with ALS caused by SOD1 mutations by collecting health information without changing their care.

  Recruiting Biogen · Boston, Massachusetts · NCT07259980

• Terazosin and ATP in ALS: see if this drug helps energy in ALS patients

  This pilot study tests whether terazosin, taken daily, can raise ATP levels and be safe for adults with ALS.

  Recruiting Early Phase 1 University of Iowa · Iowa City, Iowa · NCT07224269

• Robotic implantation of a precise brain‑computer interface to restore communication

  This project tests whether a robotically implanted Neuralink N1 brain implant can help adults with severe, irreversible speech loss from ALS, spinal cord injury, or stroke communicate again.

  Recruiting Neuralink Corp · Dallas, Texas · NCT07224256

• Safety, tolerability, and how Amisodin is processed in healthy adults

  Try whether single and short daily oral doses of Amisodin are safe and how the body handles the drug in healthy adults aged 18–55.

  Recruiting Phase 1 PRG Science & Technology Co., Ltd. · Baltimore, Maryland · NCT07221240

• Acamprosate for ALS with C9orf72 mutation

  This study tests whether acamprosate can be safely used to see if it helps people with ALS who carry a C9orf72 mutation.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07204977

• Observational study on amyotrophic lateral sclerosis

  This study is collecting health information from people with ALS, those with related genetic mutations, and healthy volunteers to help improve treatments and understand the disease better.

  Recruiting ALS Therapy Development Institute · Watertown, Massachusetts · NCT06885918

• High-tech rehabilitation program for adults with chronic neuromuscular diseases

  This trial will test whether a high-tech rehab program using robotic systems, virtual reality, and balance platforms works as well as traditional rehab to reduce fatigue and improve function in adults with chronic neuromuscular diseases.

  Recruiting Istituti Clinici Scientifici Maugeri SpA · Genova and 6 other locations · NCT06881979

• Wireless brain implant for controlling devices

  This study is testing a new wireless brain implant that helps paralyzed and amputee patients control devices just by thinking, to see if it can improve their daily lives.

  Recruiting Shanghai StairMed Technology Co., Ltd. · Shanghai, Shanghai Municipality · NCT06829212

• How interactive tasks change how people hear speech from people with ALS.

  We will test whether people without speech disorders hear speech from people with ALS differently when the speech comes from interactive versus non-interactive tasks.

  Recruiting Penn State University · University Park, Pennsylvania · NCT06828523

• Using digital technologies to measure physical impairments in ALS

  This study is testing new digital tools to see how well they can measure physical challenges in people with ALS, making it easier for patients to participate without having to travel much.

  Recruiting University of Dublin, Trinity College · Dublin, Dublin · NCT06820008

• Multicenter study using MRI to identify biomarkers in ALS patients

  This study is trying to see if brain scans and blood tests can help track how ALS changes over time in patients compared to healthy people.

  Recruiting at 3 sites University of Minnesota · Gainesville, Florida and 2 other locations · NCT06735014

• Treatment of Amyotrophic Lateral Sclerosis with TP04HN106

  This study is testing a new drug called TP04HN106 to see if it can help people with ALS feel better and improve their condition.

  Recruiting Phase 1/2 Talengen Institute of Life Sciences, Shenzhen, P.R. China. · Suzhou, Jiangsu · NCT06726577

• Validation of the Polish Fatigue Severity Scale

  This study is testing a Polish version of a questionnaire to see how well it measures fatigue in people with multiple sclerosis, ALS, and stroke.

  Recruiting at 2 sites Jagiellonian University · Krakow, Lesser Poland Voivodeship and 1 other locations · NCT06668649

• Psilocybin therapy for patients with ALS and depression

  This study is testing if psilocybin therapy can help people with ALS who are also feeling depressed.

  Recruiting Early Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT06656702

• Impact of Oral Nutrition Before Gtube Feeding in ALS Patients

  This study is testing if eating a special nutrition formula before getting a feeding tube helps people with ALS handle the tube feedings better and possibly slow down their disease.

  Recruiting Nova Southeastern University · Fort Lauderdale, Florida · NCT06609213

• Collecting data on neurodegenerative diseases progression markers

  This study is trying to find new signs that can help doctors understand how neurodegenerative diseases like Parkinson's progress, so they can improve early treatment options for patients.

  Recruiting IRCCS San Raffaele Roma · Cassino, Frosinone · NCT06596746

• Collecting data and samples from ALS patients and controls

  This study is collecting health information and samples from people with ALS, those who carry ALS-related genes, and healthy individuals to help future research on ALS and similar conditions.

  Recruiting at 37 sites St. Joseph's Hospital and Medical Center, Phoenix · Birmingham, Alabama and 36 other locations · NCT06578195

• Evaluating RAG-17 for ALS patients with SOD1 mutation

  This study is testing a new drug called RAG-17 to see if it is safe and effective for people with ALS who have a specific SOD1 gene mutation.

  Recruiting at 3 sites Phase 1 Ractigen Therapeutics. · Beijing and 2 other locations · NCT06556394

• Comparing protein patterns in skin biopsies of neurodegenerative diseases

  This study is trying to see if the patterns of certain proteins in skin samples can help doctors better understand and diagnose different neurodegenerative diseases like Alzheimer's, Parkinson's, and frontotemporal dementia.

  Recruiting Universidad Autonoma de San Luis Potosí · San Luis Potosí City · NCT06528964

• Evaluating ranolazine for treating ALS symptoms

  This study is testing if the medication ranolazine can help improve muscle cramps and quality of life for people with ALS.

  Recruiting at 6 sites Phase 2 University of California, San Francisco · San Francisco, California and 5 other locations · NCT06527222

• Using Electrical Impedance Myography to Track ALS Progression

  This study is testing if a new method using Electrical Impedance Myography can help track how ALS progresses in patients to improve future treatments.

  Recruiting at 6 sites Beth Israel Deaconess Medical Center · Phoenix, Arizona and 5 other locations · NCT06491732

• Using skin cells to model ALS

  This project will test whether skin cells taken by biopsy from people with ALS, people who carry ALS gene mutations but have no symptoms, and healthy volunteers can be used to model ALS in the lab.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06450691

• Robotically implanted brain-computer interface for patients with severe paralysis

  This study is testing a new brain implant that uses a robot to help people with severe paralysis communicate and control devices better.

  Recruiting at 2 sites Neuralink Corp · Phoenix, Arizona and 1 other locations · NCT06429735

• Exploring brain connectivity in ALS and emotional symptoms

  This study is testing how brain connections in people with ALS relate to emotional symptoms like sudden laughter or crying to better understand what's happening in their brains.

  Recruiting Aalborg University Hospital · Aalborg, Northern Jutland · NCT06396260

• Neural stem cell treatment for ALS

  This study is testing whether a new treatment using human neural stem cells can help people with ALS feel better and stay safe compared to a placebo.

  Recruiting Phase 2 Casa Sollievo della Sofferenza IRCCS · San Giovanni Rotondo, Foggia and 3 other locations · NCT06344260

• Understanding the variability in ALS through biomarkers

  This study is trying to see how different biological markers can help us understand the varying symptoms of ALS in patients and group them based on their unique characteristics.

  Recruiting at 3 sites Istituto Auxologico Italiano · Milan, MI and 2 other locations · NCT06318598

• Creating a database to study variations in motor neuron diseases

  This study is trying to learn more about the different types of motor neuron diseases in patients to better understand the condition and improve how we predict its course.

  Recruiting Istituto Auxologico Italiano · Milan, MI · NCT06318585

• Using the Quadriceps Combined Test to Diagnose and Monitor ALS

  This study is testing a new way to diagnose and track ALS using a special test to see how well the muscles and nerves are working in people who might have the disease.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT06284161

• Evaluating how communication affects speech in people with ALS

  This study is testing how different ways of talking affect speech in people with ALS compared to others their age.

  Recruiting Penn State University · University Park, Pennsylvania · NCT06266403

• Assessing the safety and effects of Darifenacin in ALS patients

  This study is testing whether the medication Darifenacin is safe and can help people with ALS by looking at its effects on muscle function.

  Recruiting at 2 sites Phase 2 McGill University · Ottawa, Ontario and 1 other locations · NCT06249867

• Monitoring movement in patients with ALS using a wearable device

  This study is testing a new wearable device to see how daily movement patterns change in people with ALS over a year.

  Recruiting at 2 sites Centre Hospitalier Universitaire de Liege · Leuven and 2 other locations · NCT06228001

• Understanding neuromuscular connections in ALS patients

  This study looks at how the connections between nerves and muscles change in people with ALS to see if there are differences compared to healthy individuals and those with other diseases.

  Recruiting University of Aarhus · Aarhus, Central Jutland · NCT06219759

• Biobank for studying ALS and Alzheimer's diseases

  This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.

  Recruiting New York Stem Cell Foundation Research Institute · New York, New York · NCT06203106

• Improving hand strength and function in ALS patients using brain and spinal cord stimulation

  This study is testing a new way to help people with ALS improve their hand strength and function by using brain and spinal cord stimulation along with exercises.

  Recruiting VA Office of Research and Development · The Bronx, New York · NCT06172621

• Identifying factors related to weight loss in ALS patients

  This study is trying to find out what causes weight loss in people with ALS by looking at their blood samples and health information to help improve their care.

  Recruiting at 7 sites University Hospital, Limoges · Lille and 8 other locations · NCT06147843

• Acetyl-L-carnitine to slow functional decline in ALS

  This trial tests whether two doses of acetyl-L-carnitine can slow loss of independence in adults with recent-onset ALS.

  Recruiting at 14 sites Phase 2/3 Mario Negri Institute for Pharmacological Research · Sydney, Australia and 18 other locations · NCT06126315

• Using a brain-computer interface to help people with speech difficulties communicate

  This study is testing a brain-computer interface to help people who can't speak due to conditions like ALS communicate by turning their thoughts into speech.

  Recruiting Massachusetts General Hospital · Sacramento, California · NCT06094205

• Targeted RNA sequencing for diagnosing ALS

  This study is testing a new way to use RNA sequencing to help diagnose ALS more accurately by looking for specific genetic changes in people who have been prescribed genetic testing for the disease.

  Recruiting at 7 sites Centre Hospitalier Universitaire de Nīmes · Bordeaux and 6 other locations · NCT06083584

• Using virtual reality to ease breathing difficulties in ALS patients on ventilation

  This study is testing if virtual reality can help ease breathing difficulties for ALS patients who use a ventilator.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, France · NCT06021938

• Accelerated repetitive transcranial magnetic stimulation for ALS

  This study is testing a new type of brain stimulation to see if it can help people with ALS feel better and improve their muscle strength over 24 weeks.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT05983211

• Evaluating a device to improve breathing in ALS patients

  This study is testing a breathing device to see if it can help people with ALS improve their cough and breathing over four weeks.

  Recruiting University Hospital, Toulouse · Toulouse, Occitanie · NCT05819931

• Evaluating the Nervous System in ALS Patients

  This study is testing if skin samples can help track how the nervous system is affected in people with ALS over 18 months after their symptoms start.

  Recruiting at 2 sites Istituti Clinici Scientifici Maugeri SpA · Telese Terme, Benevento and 1 other locations · NCT05747937

• Impact of long-term ventilation support on ALS patients and their families

  This study is testing how long-term breathing support affects the quality of life for people with ALS and their families.

  Recruiting at 8 sites Haukeland University Hospital · Bodø, Nordland and 8 other locations · NCT05744310

• Using a neural interface to help people with tetraplegia control devices with their thoughts

  This study is testing a new brain interface that helps people with tetraplegia, especially those with ALS, control devices like computers just by thinking about it.

  Recruiting at 2 sites Massachusetts General Hospital · Stanford, California and 1 other locations · NCT05724173

• Understanding the burden on ALS patients and their caregivers

  This study looks at the emotional struggles faced by people with ALS and their caregivers to see how they feel about being a burden and the stress that comes with it.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT05632757

• Collecting data and samples from ALS patients and their families

  This study is collecting blood samples and health information from people with ALS and their families to help researchers learn more about the genetic causes of the disease.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT05474235

• Collection of biological samples for diagnosing rare neurological diseases

  This study is collecting blood and spinal fluid samples from people with rare neurological diseases to see if they can find new markers that help diagnose these conditions more accurately.

  Recruiting Hospices Civils de Lyon · Bron · NCT05370079

• Using diaphragmatic ultrasound to monitor breathing function in ALS patients

  This study is testing how ultrasound can help track breathing problems in people with ALS before they need breathing support.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT05352958

• Monitoring swallowing function and quality of life in ALS patients

  This study looks at how swallowing problems affect the quality of life for people with ALS and how they feel about getting a feeding tube.

  Recruiting University Rehabilitation Institute, Republic of Slovenia · Ljubljana · NCT05336760

• Platform to analyze and understand ALS

  This study is trying to gather and analyze a lot of information about ALS and related disorders by having participants, including healthy individuals, come in for check-ups and tests over a year to help improve future research.

  Recruiting at 4 sites University of Alberta · Edmonton, Alberta and 3 other locations · NCT05204017

• Creating a biorepository of biofluids and clinical data for ALS research

  This study is collecting blood, spinal fluid, and urine samples from people with ALS and healthy individuals to help find new ways to understand and treat the disease.

  Recruiting at 12 sites Target ALS Foundation, Inc. · Phoenix, Arizona and 11 other locations · NCT05137665

• Exploring genetic causes of ALS in Norway

  This study is trying to find out if certain genes are linked to ALS by asking people with the disease in Norway about their family history and taking a blood sample for testing.

  Recruiting at 17 sites Sykehuset Telemark · Bergen and 16 other locations · NCT05119387

• Collecting blood and CSF samples to study ALS and related disorders

  This study is collecting blood and spinal fluid samples from people with ALS and similar disorders to see if they can find helpful markers for diagnosing and tracking the disease.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT05116943

• Using muscle activity measurements to improve ALS diagnosis

  This study is testing if a new way of measuring muscle activity can help doctors diagnose ALS more accurately and track how the disease changes over time.

  Recruiting at 3 sites University of Chicago · Irvine, California and 3 other locations · NCT05104710

• Analysis of ALS patient tissues and registry

  This study is trying to gather information from people with ALS to better understand the disease and find new ways to treat it.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT05067179

• Registry of ALS patients receiving Traditional Chinese Medicine

  This study is creating a registry to track ALS patients who are using traditional Chinese medicine to see how it affects their health over five years.

  Recruiting Dongzhimen Hospital, Beijing · Beijing · NCT04885374

• Measuring daily activity in patients with ALS and healthy controls

  This study is testing how active people with ALS are compared to healthy individuals by using a special device to track their daily movements over a year.

  Recruiting Centre Hospitalier Universitaire de Liege · Liège, Liège · NCT04882904

• Analyzing macrophages in ALS and related motor impairments

  This study is trying to see if looking at certain immune cells in people with ALS and related motor issues can help find new ways to treat the disease.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris · NCT04816227

• Understanding the natural history and clinical features of ALS in China

  This study looks at how Amyotrophic Lateral Sclerosis (ALS) affects people in different parts of China and how the disease has changed over time to help improve diagnosis and treatment.

  Recruiting Peking University Third Hospital · Beijing · NCT04454892

• Longitudinal study of frontotemporal lobar degeneration

  This study is trying to learn more about frontotemporal lobar degeneration by following both affected individuals and their family members over time to see how the condition develops.

  Recruiting at 25 sites Mayo Clinic · Birmingham, Alabama and 25 other locations · NCT04363684

• RAPA-501 therapy for ALS

  This study is testing a new treatment called RAPA-501 to see if it can help slow down the progression of ALS in patients.

  Recruiting Phase 2/3 Rapa Therapeutics LLC · Boston, Massachusetts · NCT04220190

• Understanding how Edaravone works in different types of ALS patients

  This study is trying to see how the medication Edaravone affects different types of ALS patients and which ones might benefit the most from it.

  Recruiting Loma Linda University · Loma Linda, California · NCT04097158

• Observing the natural history of amyotrophic lateral sclerosis in patients

  This study is looking at how amyotrophic lateral sclerosis (ALS) progresses in Chinese patients to better understand the disease and find out what might affect its course.

  Recruiting First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT04008329

• Investigation of a brain-computer interface system for communication in patients with severe disabilities

  This study is testing a new brain-computer interface that helps people with severe disabilities, like tetraplegia and ALS, communicate better by using signals from their brain.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT03567213

• Research to gather clinical data on ALS and related disorders

  This study is collecting health information from people with ALS and similar disorders to better understand these conditions and help improve future treatments.

  Recruiting at 10 sites University of Miami · Irvine, California and 10 other locations · NCT03489278

• Understanding neurodegenerative disorders like ALS and frontotemporal dementia

  This study is trying to see if adults with neurodegenerative disorders like ALS and frontotemporal dementia can join future research by checking their health and collecting samples for further testing.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03225144

• Identifying biomarkers of synaptic damage in multiple sclerosis

  This study is testing blood and spinal fluid samples from people with multiple sclerosis to see if certain markers can help us understand brain changes and how the disease progresses.

  Recruiting Neuromed IRCCS · Pozzilli, Isernia · NCT03217396

• Masitinib added to riluzole versus placebo for people with ALS

  This trial tests whether adding masitinib to standard riluzole treatment slows disease progression in people with ALS.

  Recruiting at 55 sites Phase 3 AB Science · Birmingham, Alabama and 55 other locations · NCT03127267

• Treatment for neurologic disorders using stem cells

  This study is testing whether using stem cells from patients' own bone marrow can help improve brain and nerve function in people with serious neurologic disorders that don't respond well to regular treatments.

  Recruiting at 3 sites MD Stem Cells · Westport, Connecticut and 2 other locations · NCT02795052

• MRI markers for ALS and PLS

  The study will use 3T and 7T MRI scans to see if specific brain imaging markers differ between people with ALS or PLS and healthy volunteers.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT02567136

• Registry for understanding Amyotrophic Lateral Sclerosis in the U.S.

  This study is collecting information about ALS in the U.S. to see how common it is and what factors might be linked to the disease.

  Recruiting Centers for Disease Control and Prevention · Atlanta, Georgia · NCT01772602

• Feasibility of a brain-computer interface for people with tetraplegia

  This study is testing a new brain-computer interface that helps people with tetraplegia control a computer and other devices just by thinking, to see if it’s safe and effective.

  Recruiting at 6 sites Massachusetts General Hospital · Sacramento, California and 5 other locations · NCT00912041

• Creating stem cells from existing human cells to study ALS

  This study is trying to create special stem cells from regular human cells to better understand ALS and find new treatments for it.

  Recruiting at 2 sites Hadassah Medical Organization · Jerusalem and 1 other locations · NCT00801333

• Study of healthy individuals at genetic risk for ALS

  This study is looking at healthy people who have a family history of ALS to see how their genes and environment might affect their chances of developing the disease in the future.

  Recruiting University of Miami · Miami, Florida · NCT00317616

• Research on Amyotrophic Lateral Sclerosis and related conditions

  This study is trying to understand how ALS relates to other nerve diseases and to find new ways to track its progress by looking at people with ALS, those at risk, and healthy individuals.

  Recruiting University of Miami · Miami, Florida · NCT00136500

NIH-funded research (newest 40 of 65)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating how DNA damage and repair mechanisms are altered in ALS and frontotemporal dementia.

  This study is looking at how problems with DNA repair might contribute to conditions like ALS and frontotemporal dementia, and it’s testing ways to fix these issues in cells from patients to help develop new treatments.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-9980670

• Understanding how work exposures and genes influence ALS risk

  A study is building a long-term group of people at higher risk for ALS to see how their jobs, exposures at work, and genes together affect if and when the disease might develop.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11631673

• NUZ-001: a treatment option for ALS to protect nerve cells

  A small molecule called NUZ-001 is being tested to help people with ALS by improving cell systems that keep proteins balanced and prevent harmful protein clumps.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11564156

• Alpha5 integrin's role in ALS: how a cell switch worsens disease

  Aims to understand how a specific protein called alpha5 integrin in immune cells affects ALS progression and whether blocking it can help extend life.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11540166

• C9orf72 ALS/FTD Prevent: prepping for future treatment

  This grant aims to get ready for a preventive treatment for people who carry the C9orf72 genetic change that can lead to ALS or frontotemporal dementia.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11431628

• Air pollutants and ALS: mapping environmental links to motor neuron disease

  This NIH grant explores whether different air pollutants are linked to the development of ALS and uses a large U.S. data set to look for environmental risk factors.

  NIH research Washington University · Saint Louis, United States · NIH-11423391

• CNM-Au8 Expanded Access for ALS patients across the U.S.

  A wide-access program is testing CNM-Au8, a neuroprotective medicine, for people with ALS across all 50 states.

  NIH research New York University School of Medicine · New York, United States · NIH-11415221

• Access to CNM-Au8 for people with ALS

  This program offers people with ALS access to CNM-Au8, an experimental oral therapy that aims to protect motor neurons and support cellular energy.

  NIH research New York University School of Medicine · New York, United States · NIH-11405390

• How a tiny virus carrier could protect nerve cells in ALS Veterans

  Researchers are testing a new gene-delivery approach to help protect nerve cells and improve function for people with ALS, with a focus on Veterans.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-11398343

• Digital speech markers to track bulbar decline in Spanish-speaking ALS patients

  A smartphone app will collect Spanish-language speech data from ALS patients to detect early bulbar decline and help guide timely care.

  NIH research Nova Southeastern University · Fort Lauderdale-Davie, UNITED STATES · NIH-11393889

• Pridopidine for ALS: Expanded Access Protocol for S1R-targeted Therapy

  This project tests pridopidine, a Sigma-1 receptor drug, for people with ALS to see if it can help symptoms or slow progression.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11385367

• Understanding how a genetic repeat causes harmful protein production in ALS/FTD

  Aimed at uncovering how a genetic repeat in the C9orf72 gene triggers abnormal protein production that damages nerve cells in ALS and FTD.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11384771

• Personalized anti-inflammatory T cell therapy for ALS

  This program offers a treatment using your own modified immune cells (RAPA-501) to reduce nerve inflammation for people with ALS who have low lung capacity.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11376007

• HERV-K Immunization Strategy to Help ALS Hold the Line Against Progression

  A new immunotherapy approach aims to help people with ALS by targeting a virus-related protein believed to contribute to nerve cell damage.

  NIH research Twilight Bioscience, INC. · Topsfield, United States · NIH-11373396

• AAV-CRISPR therapy for a genetic cause of ALS/FTD

  A team is testing a gene-editing approach to potentially treat a genetic form of ALS and a related dementia by targeting the C9orf72 gene with a precise CRISPR method.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11369870

• Enhancing rehabilitation for people with ALS using breathing-friendly training

  Aims to boost how well people with ALS recover and maintain movement and breathing by pairing traditional rehabilitation with a special pre-treatment called therapeutic acute intermittent hypoxia.

  NIH research University of Florida · Gainesville, United States · NIH-11367230

• Identifying how neurofilament regulation and turnover work in ALS

  AIMS to understand how neurofilaments behave in ALS to improve biomarkers and treatment strategies for people with ALS.

  NIH research Washington University · Saint Louis, United States · NIH-11364117

• TDP43 breakdown in ALS: how brain cells use lysosomes to clear trouble

  This grant supports a clinician-scientist at UCSF as they study how the protein TDP-43 is removed by lysosomal enzymes to protect nerve cells in ALS.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11362153

• Nucleolus dysfunction and ALS: understanding motor neuron disease at the cellular level

  Aims to understand how problems in the neuron’s nucleolus contribute to ALS and how key proteins behave in models to guide future therapies for people with ALS.

  NIH research Montana State University -Billings · Billings, United States · NIH-11359779

• Biomarker test for early ALS diagnosis using Nano-QuIC detection of misfolded TDP-43

  A new blood, spinal fluid, or nasal swab test using Nano-QuIC aims to detect misfolded TDP-43 early in people at risk for ALS to speed up diagnosis and treatment.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11358045

• Social connectedness in ALS patients and how speech impairments affect it

  A large study with ALS patients will track how speech and mobility difficulties influence social connections using smartphones over six months.

  NIH research Mgh Institute of Health Professions · Charlestown, UNITED STATES · NIH-11351009

• Multi-Target RNA Therapies for ALS and Alzheimer's Disease

  A patient-friendly look at a project that aims to develop RNA-based medicines to slow or modify ALS and Alzheimer’s-related diseases by targeting multiple genes.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11329236

• Spinal and brain stimulation to boost hand and arm movement in ALS

  This project pairs mild spinal-cord and brain stimulation to help people with ALS strengthen hand and arm movements.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11310758

• How chemically damaged RNA might drive ALS

  Researchers will look at whether chemically damaged RNA in nerve cells causes motor neuron loss and speeds up ALS.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11235928

• How C9orf72 RNA repeats make toxic proteins in ALS and FTD

  This research looks for how a repeated RNA sequence in the C9orf72 gene creates toxic proteins that can harm people with ALS or FTD.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11194424

• Speeding up gene‑editing to target the C9ORF72 form of ALS

  This project builds faster, more precise gene‑editing tools aimed at removing the harmful C9ORF72 repeat mutation in adults with ALS.

  NIH research Acrobat Genomics, INC. · Foster City, UNITED STATES · NIH-11194384

• Expanded access to pridopidine for people with ALS

  This program offers people living with ALS access to the experimental drug pridopidine while collecting information about safety and how it affects symptoms.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11189730

• RAPA-501 immune-cell therapy for ALS (expanded access for advanced disease)

  This program offers an experimental immune-cell treatment called RAPA-501 to people with ALS who have advanced breathing weakness (SVC <50%).

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11184331

• Engineered regulatory immune cells to protect nerves in ALS

  Engineered regulatory immune cells (CAR Tregs) that seek out misfolded SOD1 and calm inflammation around motor neurons in people with ALS.

  NIH research Celdara Medical, LLC · Lebanon, United States · NIH-11181028

• Understanding how nerve cell proteins change in ALS

  This project aims to understand how certain proteins in nerve cells, called neurofilaments, are regulated and cleared in people with ALS.

  NIH research Washington University · Saint Louis, United States · NIH-11180495

• Understanding how RNA oxidation affects the onset and progression of ALS

  This study is looking at how damaged RNA might play a role in the development of ALS, focusing on how it affects the health of motor neurons, and it's designed for people interested in understanding more about the disease and its progression.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11178244

• Understanding Social Connections for People with ALS

  This project looks at how speech and movement challenges affect social connections for people with ALS, aiming to find ways to help them stay connected.

  NIH research Mgh Institute of Health Professions · Charlestown, UNITED STATES · NIH-11170577

• Cell and tissue changes that lead to sporadic ALS and frontotemporal dementia

  This project looks at how physical changes inside cells and in their tissue can make TDP‑43 protein clump in people with sporadic ALS and frontotemporal dementia.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11163326

• Gene Therapy for ALS

  This project is exploring a new gene therapy delivered to the spine to help stop or slow down Amyotrophic Lateral Sclerosis (ALS) in its early stages.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11128828

• Using engineered immune cells to treat ALS

  This study is exploring a new way to help people with ALS by using specially designed immune cells to target harmful proteins in the body, with the hope of reducing inflammation and slowing down the disease.

  NIH research Celdara Medical, LLC · Lebanon, United States · NIH-11128419

• Understanding ALS Risk in Workers with Certain Occupations

  This project is creating a group of people at higher risk for ALS to learn how their jobs and genes might lead to the disease.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11113782

• Developing new therapies for ALS and related neurodegenerative diseases

  This study is looking for new ways to treat neurodegenerative diseases like ALS and Alzheimer's by using special medicines that target specific genes, and it invites patients to join trials to explore these exciting new options.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11092284

• Investigating new treatments for frontotemporal dementia and ALS using gene editing

  This study is looking at ways to help people with frontotemporal dementia and ALS by using a special gene-editing tool to fix a harmful gene that causes these diseases.

  NIH research J. David Gladstone Institutes · San Francisco, United States · NIH-11089394

• Improving decision-making for swallowing difficulties in ALS patients

  This study is all about helping people with ALS who have trouble swallowing by creating a helpful tool that guides them and their caregivers in making informed choices about feeding tubes, so they can feel more confident and satisfied with their decisions.

  NIH research Mgh Institute of Health Professions · Charlestown, UNITED STATES · NIH-11063965

• Understanding motor neuron damage in ALS patients

  This study is looking into what causes damage to the nerves that control movement in people with ALS, using advanced imaging and brain analysis to better understand the connection between brain changes and the symptoms you experience, all with the goal of improving how we diagnose and understand the condition.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11055203

Related topics

Quick answers

How many Amyotrophic Lateral Sclerosis clinical trials are recruiting right now?

95, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 30 countries. The most sites are in United States (45 trials), France (14 trials), Italy (13 trials), Canada (7 trials), Belgium (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 7, Phase 1: 6, Phase 2: 3, Phase 2/3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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