How physical functioning relates to quality of life for people with ALS at TidalHealth
Official title: The Impact of Physical Functioning on Self-Reported Measures of Quality of Life in the ALS Patient Population at TidalHealth Peninsula Regional
Run by TidalHealth · NCT07491484 · Data updated 2026-11-12
This study will see if physical functioning scores relate to quality of life for adults with ALS who receive care at TidalHealth Peninsula Regional.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | TidalHealth |
| Locations | 1 site (Salisbury, Maryland) |
| Status | Recruiting |
| Started | July 3, 2025 |
| Main results expected | December 2026 |
| Study ends | July 2027 |
| Registry record updated | March 24, 2026 |
| Trial ID | NCT07491484 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (age 18 or older) diagnosed with ALS who receive care at the TidalHealth Peninsula Regional ALS clinic, can read English, and can give informed consent are eligible.
✕Probably not a fit
People who are not treated at TidalHealth, cannot read English, or are unable to complete questionnaires or comply with study procedures are unlikely to receive direct benefit from participating.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective longitudinal observational study of adults with ALS treated at the TidalHealth Peninsula Regional multidisciplinary ALS clinic. Participants will complete the ALS Functional Rating Scale–Revised (ALSFRS-R) and the ALS Assessment Questionnaire-40 (ALSAQ-40) at repeated visits to track physical function and patient-reported quality of life over time. The study will analyze correlations between ALSFRS-R scores and ALSAQ-40 scores and explore whether cognitive or behavioral changes add independent effects on quality of life. Data are intended to inform clinical decisions that could help target supportive interventions to preserve or improve daily functioning and well-being.
Why it matters
Potential benefit: If successful, the results could help clinicians identify which aspects of functioning most strongly affect quality of life so they can prioritize interventions that improve patients' daily lives.
How similar studies have gone: Previous observational research has often found that declining physical function correlates with worse quality of life in ALS, while the contribution of cognitive and behavioral changes is less well defined.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Over the age of 18 * Have a diagnosis of Amyotrophic Lateral Sclerosis of Motor Neuron Disease * Able to comprehend and willing to sign an informed consent form and comply with study procedures. * Receiving care at TidalHealth Peninsula Regional Multidisciplinary ALS Clinic Exclusion Criteria: * Unable to read and understand English * Unwilling or unable to comply with the study procedure, including the presence of any condition that is likely to affect the participant's ability to comply with study procedures.
Where it's running
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TidalHealth Peninsula Regional, Inc.
Salisbury, Maryland, United States Recruiting
Study contacts
- Study coordinator: Allison D Elerding, MS
- Email: Allison.Elerding@tidalhealth.org
- Phone: 410-912-6122
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.