Exploring brain connectivity in ALS and emotional symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the structural and functional brain connectivity in patients diagnosed with amyotrophic lateral sclerosis (ALS) who also experience pseudobulbar affect (PBA). Utilizing advanced imaging techniques such as diffusion kurtosis imaging (DKI) and resting state magnetoencephalography (MEG), the researchers aim to gain insights into the neural networks involved in these conditions. By understanding these connectivity patterns, the study hopes to shed light on the underlying mechanisms of PBA in ALS patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with ALS in the last 6 months according to Gold Coast Criteria

Exclusion Criteria:

* \- Lack of ability to answer survey through own ability or through a surrogate, for example by hand controlled, eye-controlled computer and/or tablet, or through telephone interview.
* Lack of ability to cooperate.
* Pregnancy
* Drug addiction defined as the non-prescribed use of cannabis, opioids, or other narcotics.
* Alcohol addiction defined as over 21 units weekly.
* Lesional neurological diseases, such as stroke, tumor or multiple sclerosis
* Epilepsy
* Neurodegenerative diseases other than ALS
* Severe psychiatric disease such as major depression disorder, bipolar disease or schizophrenia
* Contraindication for MRI and MEG scan according to hospital guidelines
* Severe liver or kidney disease
* Dysregulated heart disease
* Ongoing treatment with any antidepressants or any antipsychotics at recruitment.
* Diagnosed with frontotemporal dementia.

Where it's running

• Aalborg University hospital
  Aalborg, Northern Jutland, Denmark Recruiting

Study contacts

• Study coordinator: Christian Holm Steenkjær
• Email: c.steenkjaer@rn.dk
• Phone: +4597660000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.