Creating stem cells from existing human cells to study ALS
Official title: Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells
Run by Hadassah Medical Organization · NCT00801333 · Data updated 2026-11-12
This study is trying to create special stem cells from regular human cells to better understand ALS and find new treatments for it.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | Hadassah Medical Organization Academic / other |
| Locations | 2 sites (Jerusalem and 1 other locations) |
| Status | Recruiting |
| Started | November 2008 |
| Main results expected | December 2030 |
| Study ends | December 2030 |
| Registry record updated | March 5, 2025 |
| Trial ID | NCT00801333 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are volunteers of any gender who are above the official age of consent.
✕Probably not a fit
Patients who are below the official age of consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to derive induced pluripotent stem cells (iPS cells) from a collection of human somatic cells to explore their potential for modeling diseases like Amyotrophic Lateral Sclerosis (ALS). The study will investigate the molecular mechanisms involved in reprogramming these cells and their properties, including their ability to differentiate into specific cell types. The iPS cells generated will be utilized for basic research, developing new therapeutic approaches, and high-throughput screening for potential treatments. All samples will be non-identified to ensure participant confidentiality.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for ALS and other diseases.
How similar studies have gone: While the approach of deriving iPS cells is established, the specific application to ALS is still being explored, indicating a mix of novel and tested methodologies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Volunteers * Male and Female Exclusion Criteria: * Below the official age of consent
Where it's running
-
Hadassah Medical Organization - Ein Kerem Campus
Jerusalem, Israel Recruiting -
Hadassah Ein Kerem
Jerusalem, Israel Recruiting
Study contacts
- Principal investigator: Benjamin E Reubinoff, MD PhD — Chairman of Department of Obstetrics & Gynecology/IVF, Hadassah Ein Kerem
- Study coordinator: Benjamin E. Reubinoff, M.D. PhD.
- Email: benjaminr@ekmd.huji.ac.il
- Phone: 011-972-2-677-4569
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.