Clinical trial Recruiting at 2 sites Observational Ages 18 and up

Creating stem cells from existing human cells to study ALS

Official title: Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells

Run by Hadassah Medical Organization · NCT00801333 · Data updated 2026-11-12

This study is trying to create special stem cells from regular human cells to better understand ALS and find new treatments for it.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment25 (estimated)
SponsorHadassah Medical Organization
Academic / other
Locations2 sites (Jerusalem and 1 other locations)
StatusRecruiting
StartedNovember 2008
Main results expectedDecember 2030
Study endsDecember 2030
Registry record updatedMarch 5, 2025
Trial IDNCT00801333 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are volunteers of any gender who are above the official age of consent.

Probably not a fit

Patients who are below the official age of consent will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to derive induced pluripotent stem cells (iPS cells) from a collection of human somatic cells to explore their potential for modeling diseases like Amyotrophic Lateral Sclerosis (ALS). The study will investigate the molecular mechanisms involved in reprogramming these cells and their properties, including their ability to differentiate into specific cell types. The iPS cells generated will be utilized for basic research, developing new therapeutic approaches, and high-throughput screening for potential treatments. All samples will be non-identified to ensure participant confidentiality.

Why it matters

Potential benefit: If successful, this research could lead to new insights and therapies for ALS and other diseases.

How similar studies have gone: While the approach of deriving iPS cells is established, the specific application to ALS is still being explored, indicating a mix of novel and tested methodologies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Volunteers
* Male and Female

Exclusion Criteria:

* Below the official age of consent

Where it's running

  • Hadassah Medical Organization - Ein Kerem Campus
    Jerusalem, Israel
    Recruiting
  • Hadassah Ein Kerem
    Jerusalem, Israel
    Recruiting

Study contacts

  • Principal investigator: Benjamin E Reubinoff, MD PhD — Chairman of Department of Obstetrics & Gynecology/IVF, Hadassah Ein Kerem
  • Study coordinator: Benjamin E. Reubinoff, M.D. PhD.
  • Email: benjaminr@ekmd.huji.ac.il
  • Phone: 011-972-2-677-4569

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  • Brain-computer interface chat tool for people with ALS

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  • LTX-002 in adults with ALS

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  • Repeated ultrasound-assisted blood-brain barrier opening in ALS

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    Recruiting Phase 1/2 Assistance Publique - Hôpitaux de Paris · Paris · NCT07571486

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.