Creating stem cells from existing human cells to study ALS
Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells
Hadassah Medical Organization · NCT00801333
This study is trying to create special stem cells from regular human cells to better understand ALS and find new treatments for it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 25 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hadassah Medical Organization (other) |
| Locations | 2 sites (Jerusalem and 1 other locations) |
| Trial ID | NCT00801333 on ClinicalTrials.gov |
What this trial studies
This project aims to derive induced pluripotent stem cells (iPS cells) from a collection of human somatic cells to explore their potential for modeling diseases like Amyotrophic Lateral Sclerosis (ALS). The study will investigate the molecular mechanisms involved in reprogramming these cells and their properties, including their ability to differentiate into specific cell types. The iPS cells generated will be utilized for basic research, developing new therapeutic approaches, and high-throughput screening for potential treatments. All samples will be non-identified to ensure participant confidentiality.
Who should consider this trial
Good fit: Ideal candidates for this study are volunteers of any gender who are above the official age of consent.
Not a fit: Patients who are below the official age of consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for ALS and other diseases.
How similar studies have performed: While the approach of deriving iPS cells is established, the specific application to ALS is still being explored, indicating a mix of novel and tested methodologies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Volunteers * Male and Female Exclusion Criteria: * Below the official age of consent
Where this trial is running
Jerusalem and 1 other locations
- Hadassah Medical Organization - Ein Kerem Campus — Jerusalem, Israel (RECRUITING)
- Hadassah Ein Kerem — Jerusalem, Israel (RECRUITING)
Study contacts
- Principal investigator: Benjamin E Reubinoff, MD PhD — Chairman of Department of Obstetrics & Gynecology/IVF, Hadassah Ein Kerem
- Study coordinator: Benjamin E. Reubinoff, M.D. PhD.
- Email: benjaminr@ekmd.huji.ac.il
- Phone: 011-972-2-677-4569
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Amyotrophic Lateral Sclerosis, ALS