Condition

Multiple System Atrophy clinical trials and research

• 35Clinical trials
• 14NIH research projects
• 17Countries

Newest Multiple System Atrophy clinical trials

All recruiting trials (35)

• Tributyrin for PSP: a virtual, early-phase study

  This study tests whether tributyrin is safe and tolerable in people with Progressive Supranuclear Palsy who are 45 or older, using virtual visits.

  Recruiting Phase 1/2 University of Michigan · Ann Arbor, Michigan · NCT07863180

• Natural history of atypical parkinsonian syndromes: a multi-center observation

  This study follows people with APS like MSA, DLB, PSP, and CBD to see how their symptoms and brain images change over time.

  Recruiting at 6 sites Second Affiliated Hospital of Soochow University · Changshu, Jiangsu and 19 other locations · NCT07805967

• Longitudinal registry of people with multiple system atrophy in China

  This study follows Chinese patients with multiple system atrophy over time to describe how the disease starts and progresses and to compare with people with Parkinson's and healthy controls.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT07644013

• Personalized magnetic brain stimulation for parkinsonian disorders

  This study will try personalized repetitive transcranial magnetic stimulation (rTMS) to see if it eases motor and non-motor symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT07570212

• Butylphthalide for Multiple System Atrophy: tests safety and symptoms

  This study tests whether 3-n-butylphthalide capsules can help reduce symptoms in people with multiple system atrophy compared with a placebo.

  Recruiting at 4 sites Phase 2/3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Nanning, Guangxi and 6 other locations · NCT07518810

• ALT001 expansion study for people with multiple system atrophy

  ALT001 is being tested in an open-label, single-center study to see if it is safe, tolerable, and shows early signs of benefit for adults with multiple system atrophy.

  Recruiting Early Phase 1 Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07476352

• Using AI to find facial and speech signs of Parkinson's and related disorders

  This project uses AI to analyze facial expressions and speech to try to find digital markers that help diagnose and tell apart Parkinson's disease, PSP, MSA, and healthy people.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07392411

• Shanghai clinical cohort for Parkinson's disease and multiple system atrophy (Reserve)

  This project will try to use clinical exams, brain scans, electrical tests, genetic and biosample data from people with Parkinson's disease or multiple system atrophy to find early markers and better subtypes.

  Recruiting Ruijin Hospital · Shanghai · NCT07353463

• Extension to see if TEV-56286 can relieve Multiple System Atrophy symptoms

  This extension will test whether daily oral TEV-56286 is safe and helps adults with Multiple System Atrophy over about 100 weeks.

  Recruiting at 41 sites Phase 2 Teva Branded Pharmaceutical Products R&D, Inc. · La Jolla, California and 40 other locations · NCT07197866

• Foralumab nasal spray for people with multiple system atrophy (Phase 2a)

  This trial will test whether foralumab given by nasal spray can be safe and help people with multiple system atrophy.

  Recruiting Phase 2 Tiziana Life Sciences LTD · Boston, Massachusetts · NCT06868628

• Implanting nerve tissue into the brain for Parkinson's and Multiple System Atrophy

  This study is testing if implanting nerve tissue into the brains of people with early-stage Parkinson's or Multiple System Atrophy can help repair damaged cells and slow down the disease.

  Recruiting Phase 1 University of Kentucky · Lexington, Kentucky · NCT06683365

• Genetic program for Progressive Supranuclear Palsy and related conditions

  This study is collecting DNA from adults with Progressive Supranuclear Palsy and similar conditions to see how genetics might help improve diagnosis and care for patients.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06647641

• Examining health services and quality of life in patients with atypical Parkinsonian syndromes

  This study looks at how people with atypical Parkinsonian syndromes, like progressive supranuclear palsy and multiple system atrophy, use health services and how their quality of life is affected by having access to specialist clinics and support services.

  Recruiting University Hospital Southampton NHS Foundation Trust · Southampton, Hampshire · NCT06645626

• Collecting data on neurodegenerative diseases progression markers

  This study is trying to find new signs that can help doctors understand how neurodegenerative diseases like Parkinson's progress, so they can improve early treatment options for patients.

  Recruiting IRCCS San Raffaele Roma · Cassino, Frosinone · NCT06596746

• Biobank for studying ALS and Alzheimer's diseases

  This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.

  Recruiting New York Stem Cell Foundation Research Institute · New York, New York · NCT06203106

• Using a non-invasive device to help manage symptoms in people with Parkinson's disease

  This study is testing a new device that uses gentle vibrations to see if it can help people with Parkinson's disease feel better and manage their symptoms.

  Recruiting Queen Mary University of London · London · NCT06174948

• NAD replenishment therapy for atypical parkinsonism

  This study is testing if taking a supplement called Nicotinamide Riboside can help people with atypical parkinsonism feel better and slow down their symptoms.

  Recruiting at 3 sites Phase 2 Haukeland University Hospital · Oslo, Oslo and 2 other locations · NCT06162013

• Evaluating a new PET imaging agent for brain conditions

  This study is testing a new imaging agent to see if it can help detect certain brain changes in people with Parkinson's disease, Multiple System Atrophy, and Dementia with Lewy Bodies, as well as in healthy individuals.

  Recruiting Early Phase 1 Massachusetts General Hospital · Charlestown, Massachusetts · NCT06098612

• Personalized treatment and telemedicine support for Multiple System Atrophy

  This study is testing if a personalized treatment plan with regular telemedicine support can improve the quality of life for people with Multiple System Atrophy and their caregivers.

  Recruiting Medical University Innsbruck · Innsbruck, Austria · NCT06072105

• Understanding pain and autonomic symptoms in Parkinson's disease and atypical parkinsonisms

  This study looks at how pain and other symptoms affect people with Parkinson's disease and multiple system atrophy to see if rehabilitation can help improve their quality of life.

  Recruiting at 9 sites Istituti Clinici Scientifici Maugeri SpA · Telese Terme, Benevento and 8 other locations · NCT05748028

• Using CPAP to treat high blood pressure in patients with autonomic failure

  This study tests if using a CPAP machine can help people with autonomic failure lower their nighttime blood pressure when they lie down.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05489575

• Synaptic Loss in Multiple System Atrophy

  This study looks at how losing connections between brain cells affects people with multiple system atrophy.

  Recruiting University of Exeter · Exeter · NCT05121012

• Collection of cerebrospinal fluid for cognitive disorder research

  This study is collecting spinal fluid from people with cognitive disorders like Alzheimer's and dementia to help improve how these diseases are diagnosed.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT04844060

• Using an accelerometer to measure symptoms of neurogenic orthostatic hypotension

  This study is testing if using a device to track how long people with neurogenic orthostatic hypotension can stay upright helps show if their medication works better than a placebo.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT04782830

• Swallowing rehabilitation for patients with multiple system atrophy

  This study is testing a swallowing rehabilitation program to see if it can help people with multiple system atrophy improve their swallowing safety and efficiency.

  Recruiting Seoul National University Hospital · Seoul · NCT04782284

• Assessing swallowing function in patients with neurodegenerative diseases

  This study looks at how well people with neurodegenerative diseases, like Parkinson's and Motor Neuron Disease, can swallow and how it affects their quality of life.

  Recruiting at 16 sites Kliniken Beelitz GmbH · Innsbruck, Tyrol and 15 other locations · NCT04706234

• Neurodegenerative Diseases Registry

  This registry collects data from adults with neurodegenerative conditions to help doctors distinguish between Parkinsonian syndromes and related disorders and understand disease progression over time.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT04472130

• Insulin resistance in multiple system atrophy

  This project will test whether people with multiple system atrophy have signs of insulin resistance in fasting blood and neural-derived plasma exosomes compared with healthy adults.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT04250493

• Imaging with [18F]F-DOPA in patients with autonomic failure

  This study is testing a special imaging technique to see if it can help identify early signs of neurodegenerative diseases in people with autonomic failure.

  Recruiting Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT04246437

• Evaluating ION464 for Multiple System Atrophy

  This study is testing a new drug called ION464 to see if it is safe and helps adults with multiple system atrophy feel better over a 12-week period and beyond.

  Recruiting at 14 sites Phase 1 Ionis Pharmaceuticals, Inc. · Innsbruck and 14 other locations · NCT04165486

• Using neuroimaging to improve diagnosis and prognosis of Parkinson's disease and related conditions

  This study is trying to find brain imaging markers that can help doctors better diagnose and predict how Parkinson's disease and similar conditions will progress in patients.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03872102

• A study on early diagnosis and biomarkers for dementia and related diseases

  This study is testing new ways to spot dementia and related diseases early by looking for specific markers in the brain and body, to help people at high risk and track how well new treatments are working.

  Recruiting at 2 sites Skane University Hospital · Ängelholm and 1 other locations · NCT03174938

• Heat application for managing high blood pressure in patients with autonomic failure

  This study is testing if using a heating pad on the belly at night can help people with autonomic failure lower their high blood pressure while lying down.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT03042988

• Observing the progression of synucleinopathies

  This study is tracking how synucleinopathies, a group of brain diseases, progress in adults with symptoms like dizziness when standing up to better understand their development over time.

  Recruiting at 8 sites NYU Langone Health · Boston, Massachusetts and 7 other locations · NCT01799915

• Registry for patients with rare diseases

  This study is creating a central registry for people with rare diseases to help connect them with researchers and improve treatments.

  Recruiting Sanford Health · Sioux Falls, South Dakota · NCT01793168

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Integrated MRI biomarkers to diagnose and monitor multiple system atrophy

  This project will help doctors use MRI markers to better diagnose multiple system atrophy and track how the disease progresses.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11428110

• Clinical Trial Readiness for Multiple System Atrophy

  A multi-center study to help people with multiple system atrophy by creating better clinical and biological measures to use in future drug trials.

  NIH research New York University School of Medicine · New York, United States · NIH-11392980

• Single-cell brain profiling to map MSA cell changes

  Researchers will map gene activity in individual brain cells from people who had multiple system atrophy to understand how the disease affects cells in key brain regions.

  NIH research New York University School of Medicine · New York, United States · NIH-11380875

• Investigating how inflammation caused by alpha-synuclein affects multiple system atrophy

  This study is looking at how inflammation affects multiple system atrophy (MSA) and aims to understand how the immune system might play a role in the disease, with the hope of finding new ways to help people with MSA.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11168261

• Understanding brain inflammation in multiple system atrophy

  This research explores how a specific immune signal, interferon-gamma, contributes to brain damage in multiple system atrophy.

  NIH research Yale University · New Haven, United States · NIH-11144952

• Single-cell gene map of brains from people with multiple system atrophy

  This project reads gene activity in individual brain cells from people with multiple system atrophy to find cell-specific changes linked to the disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11142461

• Identifying biomarkers for multiple system atrophy using gene expression analysis

  This study is looking at how multiple system atrophy (MSA) affects brain cells by examining changes in their genes, and it aims to find new ways to diagnose and treat the condition, with opportunities for patients to help by sharing samples.

  NIH research Colorado State University · Fort Collins, United States · NIH-10998160

• A new gene therapy to stop protein misfolding in multiple system atrophy.

  This study is exploring a new gene therapy that uses CRISPR technology to create a special version of a protein linked to multiple system atrophy (MSA), with the goal of stopping the disease from getting worse.

  NIH research Colorado State University · Fort Collins, United States · NIH-10922836

• Using stem cells to treat multiple system atrophy

  This study is looking at whether using your own stem cells, delivered into the spinal canal, can help slow down the progression of multiple system atrophy (MSA), and it's for people living with this challenging condition.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10872108

• Creating blood tests for diagnosing multiple system atrophy and Parkinson's disease

  This study is looking for ways to make it easier to tell the difference between multiple system atrophy and Parkinson's disease by testing blood samples for special markers, which could help with earlier diagnosis and better treatment for people with these conditions.

  NIH research University of Washington · Seattle, United States · NIH-10867644

• Investigating how a specific immune response contributes to brain damage in a mouse model of multiple system atrophy.

  This study is looking at how a protein called interferon-gamma affects the progression of multiple system atrophy (MSA) by exploring its role in inflammation and nerve damage, which could help us find new treatments for people with MSA.

  NIH research Yale University · New Haven, United States · NIH-10856291

• Investigating brain changes in multiple system atrophy

  This study is looking at brain tissue from people with multiple system atrophy (MSA) to learn more about how the disease affects different brain cells, especially those that support nerve health, which could help us find new ways to treat MSA in the future.

  NIH research New York University School of Medicine · New York, United States · NIH-10801665

• Investigating cholesterol metabolism in multiple system atrophy

  This study is looking at how cholesterol levels change in people with multiple system atrophy (MSA) to see if it can help us find new ways to treat this condition, and we’d love for patients to help by sharing some samples.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10792884

• Developing imaging agents for detecting alpha-synuclein in Multiple System Atrophy

  This study is working on a special imaging tool that can help doctors see the buildup of a protein linked to Multiple System Atrophy (MSA) in the brain, which could lead to better diagnosis and understanding of the disease for patients.

  NIH research Washington University · Saint Louis, United States · NIH-10581664

Related topics

Quick answers

How many Multiple System Atrophy clinical trials are recruiting right now?

35, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (14 trials), China (7 trials), France (4 trials), Italy (4 trials), United Kingdom (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 3, Early Phase 1: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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