High-tech rehabilitation program for adults with chronic neuromuscular diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, pragmatic, parallel-assignment trial compares a high-tech rehabilitation program (robotic devices, virtual reality, and stabilometric platforms) with conventional physiotherapy in adults with chronic neuromuscular diseases such as ALS, CIDP, and Charcot–Marie–Tooth. The primary goal is to show non-inferiority in fatigue levels, while secondary outcomes include balance (Berg Balance Scale), motor function, sarcopenia markers, cognitive engagement, and quality of life. Eligible participants who can walk independently or with assistance are randomized to receive a standardized course of either high-tech or traditional rehabilitation at participating Italian centers. Outcomes are measured from baseline to the end of the intervention period to compare improvements between groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with a confirmed diagnosis of chronic neuromuscular diseases (e.g. ALS, CIDP, CMT)
* Patient able to walk independently or with assistance
* Patients capable of understanding and adhering to the study protocol.
* Patients who have provided informed consent to participate in the study

Exclusion Criteria:

* Patients with unstable medical conditions (e.g. severe cardiovascular diseases, such as "New York Heart Association" - NYHA=4, respiratory distress not compensated by ventilation) that could interfere, in the clinician's judgment, with their ability to safely participate in the study or to perform the assessments related to the protocol.
* Patients currently participating in other clinical trials that could interfere with this study.
* Pregnant women.

Where it's running

• Istituti Clinici Scientifici Maugeri IRCCS, Milan Institute
  Milan, Italy Recruiting
• IRCCS Azienda Ospedaliera Universitaria San Martino - Genova
  Genova, Italy Not yet recruiting
• Azienda Ospedaliero-Universitaria di Modena
  Modena, Italy Not yet recruiting
• Istituti Clinici Scientifici Maugeri
  Montescano, Italy Not yet recruiting
• Istituti Clinici Scientifici Maugeri IRCCS
  Pavia, Italy Not yet recruiting
• Fondazione Don Carlo Gnocchi Onlus
  Roma, Italy Not yet recruiting

Study contacts

• Study coordinator: Christian Lunetta, MD
• Email: christian.lunetta@icsmaugeri.it
• Phone: +39 0250725266

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.