Clinical trial Recruiting at 1 site Observational Ages 18 to 90

Analysis of ALS patient tissues and registry

Official title: Analysis of Human ALS Tissues and Registry of ALS Patients

Run by University of Illinois Chicago · NCT05067179 · Data updated 2026-11-12

This study is trying to gather information from people with ALS to better understand the disease and find new ways to treat it.

Quick facts

Study typeObservational
Ages18 Years to 90 Years
SexAll
Enrollment40 (estimated)
SponsorUniversity of Illinois Chicago
Academic / other
Locations1 site (Chicago, Illinois)
StatusRecruiting
StartedSeptember 1, 2020
Main results expectedJanuary 1, 2030
Study endsJanuary 1, 2030
Registry record updatedJuly 8, 2026
Trial IDNCT05067179 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults over 18 with an established diagnosis of ALS who can provide informed consent.

Probably not a fit

Patients under 18 or those without a diagnosis of ALS will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research focuses on understanding Amyotrophic Lateral Sclerosis (ALS) by collecting data from patients through physical examinations, electrodiagnostic testing, and MRI scans. Patients will consent to have their information entered into a database to monitor disease progression and contribute to research efforts. Additionally, a separate consent will allow for postmortem tissue collection to facilitate in-depth cellular and molecular analyses. The goal is to identify reliable markers of disease progression and potential treatment avenues.

Why it matters

Potential benefit: If successful, this research could lead to a better understanding of ALS and the development of effective treatments.

How similar studies have gone: While there have been various studies on ALS, this approach of combining premortem and postmortem analyses is relatively novel and aims to fill significant gaps in understanding the disease.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients over the age of 18
* Established diagnosis of ALS
* Able and willing to give written informed consent and must authorize release and use of protected health information

Exclusion Criteria:

* Patients below the age of 18
* No diagnosis of ALS

Where it's running

  • University of Illinois at Chicago
    Chicago, Illinois, United States
    Recruiting

Study contacts

  • Principal investigator: Jeffrey Loeb, MD — University of Illinois Chicago
  • Study coordinator: Ayo Fasawe
  • Email: afasawe@ilstu.edu
  • Phone: 312-413-7908

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  • Brain-computer interface chat tool for people with ALS

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  • BIIB147 safety and how it behaves in adults with ALS

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    Recruiting at 2 sites Phase 1/2 Biogen · St Louis, Missouri and 1 other locations · NCT07855211

  • Aims to restore UNC13A function in people with ALS

    This trial tests TRCN-1023 in adults with ALS to see if it’s safe, tolerated, and shows early signs of benefit.

    Recruiting at 6 sites Phase 1/2 Trace Neuroscience, Inc. · Lübeck, Schleswig-Holstein and 5 other locations · NCT07674667

  • LTX-002 in adults with ALS

    A study will test whether the experimental drug LTX-002 is safe and tolerable in adults with ALS and see how the body handles the drug and how it affects ALS indicators.

    Recruiting at 4 sites Phase 1/2 Leal Therapeutics, Inc · Lübeck and 4 other locations · NCT07660614

  • Repeated ultrasound-assisted blood-brain barrier opening in ALS

    This trial tests whether repeatedly opening the blood-brain barrier with ultrasound is safe and may help people with ALS.

    Recruiting Phase 1/2 Assistance Publique - Hôpitaux de Paris · Paris · NCT07571486

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.