Using SleepImage to detect respiratory failure in people with ALS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects SleepImage recordings during participants' routine overnight sleep tests and compares those signals to the standard respiratory data collected at the visit. SleepImage uses tonometry and cardiopulmonary coupling (CPC) analysis to characterize stable versus unstable sleep and breathing patterns in addition to pulse oximetry. Researchers will compare SleepImage-derived markers of breathing instability against existing clinical and physiological measures to determine diagnostic accuracy for impending respiratory failure. The goal is to identify whether SleepImage can provide an earlier or more sensitive signal than peripheral oxygen measures alone to guide timing of noninvasive ventilation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18 and over with a Neurologist confirmed diagnosis of ALS

Exclusion Criteria:

* Patients with known respiratory disease
* Unstable cardiac disease, stable hypertension or ischaemic heart disease
* Current NIV use
* Inability to give consent (expected \~15% due to frontotemporal dementia)

Where it's running

• Royal Brompton Hospital
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Professor Michael Polkey
• Email: mike.polkey@nhs.net
• Phone: 020 7352 8121

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.