Identifying how neurofilament regulation and turnover work in ALS

Who could benefit from this research

What this research studies

This project studies the biology of neurofilaments in ALS, focusing on how they are modified, assembled, and broken down, and how these processes relate to disease progression. Researchers will develop and apply advanced proteomic methods to measure neurofilament fragments and their modifications in cerebrospinal fluid. The work builds on prior findings that neurofilament levels change with therapy and disease activity, seeking to improve biomarker reliability and potentially guide future therapies. The study takes place at Washington University in Saint Louis with a team led by Cindy V. Ly and collaborators, using human samples and disease-relevant models to understand mechanisms in ALS.

Why it matters

Where this research is happening

• Washington University
  Saint Louis, United States Active

Researchers

• Principal investigator: Ly, Cindy V — Washington University
• Study coordinator: Ly, Cindy V

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.