Condition

Motor Neuron Disease clinical trials and research

• 18Clinical trials
• 14NIH research projects
• 1New in 30 days
• 16Countries

Newest Motor Neuron Disease clinical trials

All recruiting trials (18)

• Registering medical data and care outcomes for ALS, SMA, and other motor disorders

  This registry slowly collects routine-care information from adults with ALS, SMA, or other motor disorders to see how they’re treated and how care affects outcomes.

  Recruiting Ambulanzpartner Soziotechnologie APST GmbH · Berlin, State of Berlin · NCT07900672

• How physical functioning relates to quality of life for people with ALS at TidalHealth

  This study will see if physical functioning scores relate to quality of life for adults with ALS who receive care at TidalHealth Peninsula Regional.

  Recruiting TidalHealth · Salisbury, Maryland · NCT07491484

• Acamprosate for ALS with C9orf72 mutation

  This study tests whether acamprosate can be safely used to see if it helps people with ALS who carry a C9orf72 mutation.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07204977

• Robotically implanted Neuralink N1 brain-computer interface to control external devices

  This study will test whether a robotically implanted Neuralink N1 brain-computer interface can safely help people with high spinal cord injuries or ALS control computers and other external devices.

  Recruiting at 2 sites Neuralink Corp · London, Greater London and 1 other locations · NCT07127172

• Robotically implanted brain chip to help control external devices

  This tests a wireless, rechargeable brain implant (Neuralink N1) and a robot surgical system (R1) to help people with severe arm and hand paralysis control external devices.

  Recruiting Neuralink Corp · Abu Dhabi · NCT06992596

• Observational study on amyotrophic lateral sclerosis

  This study is collecting health information from people with ALS, those with related genetic mutations, and healthy volunteers to help improve treatments and understand the disease better.

  Recruiting ALS Therapy Development Institute · Watertown, Massachusetts · NCT06885918

• Digital app for monitoring speech and health in neurodegenerative conditions

  This study is testing a digital app that records and analyzes speech to see if it can help monitor and detect neurodegenerative conditions like dementia and Parkinson's disease in both patients and healthy volunteers.

  Recruiting University of Edinburgh · Edinburgh · NCT06450418

• Understanding the variability in ALS through biomarkers

  This study is trying to see how different biological markers can help us understand the varying symptoms of ALS in patients and group them based on their unique characteristics.

  Recruiting at 3 sites Istituto Auxologico Italiano · Milan, MI and 2 other locations · NCT06318598

• Creating a database to study variations in motor neuron diseases

  This study is trying to learn more about the different types of motor neuron diseases in patients to better understand the condition and improve how we predict its course.

  Recruiting Istituto Auxologico Italiano · Milan, MI · NCT06318585

• Impact of long-term ventilation support on ALS patients and their families

  This study is testing how long-term breathing support affects the quality of life for people with ALS and their families.

  Recruiting at 8 sites Haukeland University Hospital · Bodø, Nordland and 8 other locations · NCT05744310

• Genetic analysis of hereditary spastic paraplegia

  This study is trying to find out the genetic causes of hereditary spastic paraplegia to help improve diagnosis and treatment for people living with this condition.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT05354622

• Using brain-computer interfaces to control assistive devices for motor recovery

  This study tests whether using brain-computer interfaces can help people with motor disorders control assistive devices better and improve their movement skills.

  Recruiting University of Texas at Austin · Austin, Texas · NCT05183152

• Creating a biorepository of biofluids and clinical data for ALS research

  This study is collecting blood, spinal fluid, and urine samples from people with ALS and healthy individuals to help find new ways to understand and treat the disease.

  Recruiting at 12 sites Target ALS Foundation, Inc. · Phoenix, Arizona and 11 other locations · NCT05137665

• Understanding Spinal and Bulbar Muscular Atrophy through Biomarkers

  This study is trying to understand how Spinal and Bulbar Muscular Atrophy affects people by collecting health information and tests from men over 18, both with and without the condition.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04944940

• Assessing swallowing function in patients with neurodegenerative diseases

  This study looks at how well people with neurodegenerative diseases, like Parkinson's and Motor Neuron Disease, can swallow and how it affects their quality of life.

  Recruiting at 16 sites Kliniken Beelitz GmbH · Innsbruck, Tyrol and 15 other locations · NCT04706234

• Detecting awareness in patients with disorders of consciousness

  This study tests if a special brain-monitoring technology can help doctors see if patients with severe consciousness disorders are aware and then teach those who are aware how to communicate.

  Recruiting at 17 sites University of Ulster · Dublin and 17 other locations · NCT03827187

• Evaluating a new device for assessing muscle and nerve disorders

  This study is testing a new device that uses electrical signals to see if it can help diagnose muscle and nerve disorders in both healthy people and those with neuromuscular diseases.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01900132

• Understanding inherited neurological disorders

  This study is trying to learn more about inherited neurological disorders by looking at the medical history and genetics of people who have or might have these conditions.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT00004568

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• T cell roles in a rare juvenile ALS form (SETX-related)

  A study to understand how immune cells, especially CD8 T cells, influence a rare juvenile form of ALS caused by SETX mutations.

  NIH research University of California-Irvine · Irvine, United States · NIH-11395430

• Investigating how motor neurons contribute to premature death in spinocerebellar ataxia type 1

  A study at Baylor College of Medicine is exploring why people with spinocerebellar ataxia type 1 also develop muscle weakness and breathing problems, and how motor neurons are involved.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11387891

• Understanding how sphingolipid changes cause immune-nerve damage in ALS

  A Johns Hopkins team tests how abnormal lipid production may drive motor neuron disease in people with ALS, using patient-derived cells and mouse models.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11384898

• Blocking EphA4 to protect motor neurons in ALS

  This project develops and refines drug-like molecules that target the EphA4 protein to try to protect motor neurons in people with ALS.

  NIH research University of California Riverside · Riverside, United States · NIH-11331257

• Early causes of frontotemporal dementia and motor neuron disease

  Researchers are using donated brain tissue from people with genetic and non-genetic frontotemporal dementia and motor neuron disease to find early changes that lead to TDP-43 protein problems.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11246968

• Motor neuron causes of weakness and breathing problems in spinocerebellar ataxia type 1

  Seeing if damage to motor neurons explains muscle weakness, trouble breathing and early death in people with spinocerebellar ataxia type 1.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11169736

• T cells in a rare juvenile form of ALS (ALS4)

  This research looks at whether certain CD8 T immune cells are linked to ALS4, a rare juvenile form of ALS, by studying mouse models and samples from people with ALS.

  NIH research University of California-Irvine · Irvine, United States · NIH-11143833

• Investigating a protein's role in neuron health and its link to motor neuron diseases.

  This study is looking at a protein called Sec20 in fruit flies to see how its loss affects nerve cells and could be linked to motor neuron diseases like ALS and FTD, with the hope of finding new ways to help people with these conditions.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11126452

• Targeting a specific protein to help treat motor neuron disease

  This study is looking at a specific part of the body called the EphA4 receptor to find new treatments for ALS, a serious disease that affects movement, with the hope that these new therapies can help slow down or stop the disease for patients.

  NIH research University of California Riverside · Riverside, United States · NIH-11086636

• Investigating neuron dysfunction in ALS and its impact on motor control

  This study is looking at how the loss of certain brain cells affects movement in people with ALS, using mice to learn more about the connections between these cells and the ones that control movement, with hopes of finding new ways to help treat the disease.

  NIH research Winifred Masterson Burke Med Res Inst · White Plains, United States · NIH-10991312

• Understanding how a specific type of ALS spreads

  This research explores how a specific type of ALS, called SOD1-ALS, might spread through the body like a prion, affecting how quickly the disease progresses.

  NIH research University of Florida · Gainesville, United States · NIH-10983750

• Understanding how motor neuron disease affects patients with Spinocerebellar Ataxia Type 1

  This study is looking at how nerve cells that control movement are affected in people with Spinocerebellar Ataxia Type 1 (SCA1) to better understand the disease and find new ways to help improve symptoms like muscle weakness and coordination problems.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10914282

• How the Sec20 protein affects nerve cells and may relate to ALS and frontotemporal dementia

  This project looks at whether changes in the Sec20 protein cause nerve cell damage through mitochondrial and recycling (autophagy) problems that link to adult-onset ALS and frontotemporal dementia.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10829253

• Investigating brain changes in frontotemporal dementia and motor neuron disease.

  This study is looking at how certain biological factors affect brain health in people with frontotemporal dementia and motor neuron disease, by examining brain tissue samples to better understand what makes these conditions unique and how they progress, and it includes both patients and healthy individuals to get a com

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10449356

Related topics

Quick answers

How many Motor Neuron Disease clinical trials are recruiting right now?

18, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (9 trials), United Kingdom (3 trials), Italy (3 trials), Germany (2 trials), Norway (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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