Condition

ALS clinical trials and research

• 15Clinical trials
• 6Countries

Newest ALS clinical trials

All recruiting trials (15)

• Decoding Mandarin speech features from brain-surface signals

  This project will try to decode imagined Mandarin speech, including lexical tones, from high-density brain-surface (ECoG) signals in adult patients who are having clinically indicated cortical electrode placement.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07460037

• At-home cortico-spinal tDCS for ALS.

  This treatment tests whether daily at-home cortico-spinal tDCS can slow nerve damage and symptoms in adults with early ALS.

  Recruiting University of Trieste · Trieste, Trieste · NCT07006571

• Cell therapy using induced pluripotent stem cells for ALS treatment

  This study is testing a new cell therapy using stem cells to see if it can safely help people with ALS feel better.

  Recruiting Shanghai East Hospital · Shanghai, Shanghai Municipality · NCT06765564

• Multicenter study using MRI to identify biomarkers in ALS patients

  This study is trying to see if brain scans and blood tests can help track how ALS changes over time in patients compared to healthy people.

  Recruiting at 3 sites University of Minnesota · Gainesville, Florida and 2 other locations · NCT06735014

• Evaluating AMX0114 for treating ALS in adults

  This study is testing a new drug called AMX0114 to see if it is safe and how well it works for adults with ALS.

  Recruiting at 14 sites Phase 1 Amylyx Pharmaceuticals Inc. · La Jolla, California and 13 other locations · NCT06665165

• Using a brain-computer interface to help people with tetraplegia communicate

  This study is testing a new brain-computer interface to help people with tetraplegia communicate more easily using a tablet.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06511934

• Advancing genomic medicine using electronic health records

  This study is trying to see if using electronic health records and helpful reminders can get more patients tested for genetic conditions in a way that doctors can easily use.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06377033

• Biobank for studying ALS and Alzheimer's diseases

  This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.

  Recruiting New York Stem Cell Foundation Research Institute · New York, New York · NCT06203106

• Data repository for ALS and other motor neuron disorders

  This study collects and shares information from people with ALS and other motor neuron disorders to help researchers learn more about these conditions.

  Recruiting at 18 sites Massachusetts General Hospital · Loma Linda, California and 17 other locations · NCT05966038

• Breathing and swallowing training for people with ALS

  This study is testing if breathing and swallowing training can help people with ALS breathe better and improve their quality of life.

  Recruiting Nova Southeastern University · Fort Lauderdale, Florida · NCT05913882

• Imaging brain inflammation in neurodegenerative diseases

  This study is testing how levels of certain proteins in the brain relate to neurodegenerative diseases like Alzheimer's and Parkinson's by comparing them in patients and healthy volunteers using brain scans.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04396873

• Research on familial ALS and genetic factors

  This study is trying to understand how familial ALS develops by looking at family members of those affected and offering genetic counseling to help them learn about their risk and possibly find new ways to prevent or treat the disease.

  Recruiting Columbia University · New York, New York · NCT03865420

• Using brain signals to control devices for movement and speech

  This study is testing if people with severe neurological disorders can use brain signals to control devices that help them move and speak better.

  Recruiting University of California, San Francisco · San Francisco, California · NCT03698149

• Investigation of factors related to amyotrophic lateral sclerosis (ALS)

  This study is trying to understand how different factors like ethnicity, immigration status, and military service might affect people with ALS in Israel.

  Recruiting Hadassah Medical Organization · Jerusalem · NCT03366506

• Treatment for neurologic disorders using stem cells

  This study is testing whether using stem cells from patients' own bone marrow can help improve brain and nerve function in people with serious neurologic disorders that don't respond well to regular treatments.

  Recruiting at 3 sites MD Stem Cells · Westport, Connecticut and 2 other locations · NCT02795052

Related topics

Quick answers

How many ALS clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (11 trials), China (2 trials), Israel (2 trials), Italy (2 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →