Understanding the variability in ALS through biomarkers
Dissezione Fenotipica Guidata da Biomarcatori Della Sclerosi Laterale Amiotrofica/Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis
This study is trying to see how different biological markers can help us understand the varying symptoms of ALS in patients and group them based on their unique characteristics.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Istituto Auxologico Italiano Academic / other |
| Locations | 3 sites (Milan, MI and 2 other locations) |
| Trial ID | NCT06318598 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the clinical variability among patients with Amyotrophic Lateral Sclerosis (ALS) by utilizing multidimensional biomarkers. It seeks to identify which biomarkers correlate with genetic and phenotypic characteristics of ALS and to categorize patients into more homogeneous subgroups. Participants will undergo a series of evaluations, including neurological, neurophysiological, and neuropsychological assessments, along with whole exome sequencing and biomarker measurements in cerebrospinal fluid and plasma.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with ALS or other motor neuron diseases who live near the study centers.
Not a fit: Patients who refuse to participate or are unable to attend follow-up visits may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized treatment approaches for ALS patients based on their specific biomarker profiles.
How similar studies have performed: Other studies have shown promise in using biomarkers to understand ALS, indicating that this approach has potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosis of ALS or other motor neuron disease * residence near the study centers Exclusion Criteria: * refusal to participate to the study * unable/unwilling to perform follow-up visits
Where this trial is running
Milan, MI and 2 other locations
- Ospedale San Raffaele — Milan, Mi, Italy (Recruiting)
- Ospedale San Luca — Milan, Mi, Italy (Recruiting)
- AOU Città della Salute e della Scienza — Torino, To, Italy (Recruiting)
Study contacts
- Study coordinator: Nicola Ticozzi, MD, PhD
- Email: n.ticozzi@auxologico.it
- Phone: +390261911
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.