Understanding neuromuscular connections in ALS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to describe changes in neuromuscular connections in patients with amyotrophic lateral sclerosis (ALS). It consists of three substudies focusing on muscle reinnervation capacity, blood biomarkers related to neuromuscular transmission, and the relationship between nerve stimulation responses and physical fatigue. The study will include ALS patients, healthy controls, and disease controls to compare findings across different groups. Participants will undergo neurophysiological examinations to gather data on their condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Referred to clinical neurophysiological examination on suspicion of motor neuron disease or diagnosed with ALS according to Gold Coast criteria within the last 3 months.
* Age ≥18 years old
* Able and willing to provide informed consent

Exclusion Criteria:

* Former central or peripheral nervous system disease
* Diabetes
* Electrophysiological signs of polyneuropathy at baseline visit
* Pacemaker
* Pregnancy

For disease controls the exclusion criteria are the same, but the inclusion criteria:

* Diagnosed with disease with slow, progressive loss of motor neurons
* Age ≥18 years old
* Able and willing to provide informed consent

Where it's running

• Department of Neurology, Aarhus University Hospital
  Aarhus, Central Jutland, Denmark Recruiting

Study contacts

• Principal investigator: Jesper H Storgaard, MD — Aarhus University and Department of Neurology, Aarhus University Hospital
• Study coordinator: Jesper Storgaard, MD
• Email: jesstg@rm.dk
• Phone: 004520231903

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.